[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599270":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":28,"locations":34,"responsibleParty":53,"collaborators":25,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":25,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":37,"whyStopped":25,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"University of Exeter","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control","ACTIVE_COMPARATOR","Placebo with bitter agent (Bitrex), to flavour match to ketone condition, whey protein (0.3 g\u002Fkg), and milk fat (to match the caloric content of the ketone condition).",[13],"Dietary Supplement: Control",{"label":15,"type":16,"description":17,"interventionNames":18},"Ketone monoester","EXPERIMENTAL","Ketone monoester ((R)-3-hydroxybutyl (R)-3-hydroxybutyrate) and whey protein (0.3 g\u002Fkg)",[19],"Dietary Supplement: Ketone Monoester (KE) and whey protein beverage",[21,26],{"type":22,"name":23,"description":17,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Ketone Monoester (KE) and whey protein beverage",[15],null,{"type":22,"name":9,"description":11,"armGroupLabels":27,"otherNames":25},[9],[29],{"name":30,"role":31,"phone":32,"phoneExt":25,"email":33},"Alistair Monteyne, PhD","CONTACT","+44 (0)1392 72 4774","a.monteyne2@exeter.ac.uk",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Health and Life Sciences","RECRUITING","Exeter","Devon","EX1 2LU","United Kingdom","UK",{"type":44,"coordinates":45},"Point",[46,47],-3.52751,50.7236,{"lat":47,"lon":46},[50,51],{"name":30,"role":31,"phone":32,"phoneExt":25,"email":33},{"name":30,"role":52,"phone":25,"phoneExt":25,"email":25},"PRINCIPAL_INVESTIGATOR",{"type":54,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100599270","the-effect-of-ketone-monoesters-on-skeletal-muscle-protein-synthesis-and-whole-body-protein-metabolism-100599270",false,"NCT07082309","The Effect of Ketone Monoesters on Skeletal Muscle Protein Synthesis and Whole-body Protein Metabolism.","WAKM","Inclusion Criteria:\n\n• BMI 18-30\n\nExclusion Criteria:\n\n* Body mass index (BMI) \\\u003C 18.5 or \\> 30 kg\u002Fm2\n* Age \\\u003C 18 or \\> 40\n* Regularly smokes\n* Type 2 diabetes\n* Cardiovascular disease, metabolic disease and hypertension (≥ 140\u002F90 mmHg)\n* Gastrointestinal disorders\n* Use medicines that may impact protein metabolism or that are anti-inflammatory (determined at the screening)\n* Pregnancy",true,"ALL","18 Years","40 Years",{"count":67,"type":68},12,"ESTIMATED","INTERVENTIONAL",[71],"NA","The ketone β-hydroxybutyrate (BHB) is endogenously produced during periods of low glucose availability, serving as an alternative metabolic fuel. Beyond its role as an energy substrate, BHB acts as a pleiotropic signalling molecule, modulating various physiological processes across multiple tissues. BHB can also be ingested orally as a ketone monoester, transiently elevating plasma concentrations of BHB to a level similar to those seen following several days of fasting, thereby obviating the need for dietary manipulation. The influence of BHB on human skeletal muscle protein metabolism remains poorly understood, although emerging evidence suggests that BHB may play a role in regulating muscle protein turnover. As such, BHB supplementation may support skeletal muscle remodelling and offer therapeutic benefits, and investigating this is of considerable interest. This study will investigate the ability of oral BHB ingestion - co-ingested with protein - to stimulate skeletal muscle anabolism in young healthy adults. A dual amino acid stable isotope tracer approach will be utilised to determine postprandial (i.e., fed state) muscle protein synthesis (MPS) rates and whole-body amino acid kinetics, given BHBs systemic effects. This research will advance our understanding of the fundamental biology of exogenous ketosis and provide insight into the potential of BHB supplementation as a novel nutritional strategy to optimise muscle mass and quality.",[74],"Healthy Participants",[76,77,78],"ketone monoesters","muscle protein synthesis","amino acid metabolism","2025-07-15",{"date":81,"type":82},"2025-07-24","ACTUAL",{"date":84,"type":82},"2025-06-04",{"date":86,"type":68},"2027-07",{"name":5,"class":6},1]