[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558104":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":36,"responsibleParty":56,"collaborators":18,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":18,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":18,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":39,"whyStopped":18,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Kaohsiung Veterans General Hospital.","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Melatonin group","EXPERIMENTAL","Patients received melatonin supplementation for at least a two-month period prior to IVF cycles",[13],"Dietary Supplement: Melatonin",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","NO_INTERVENTION","Patients did not receive melatonin supplementation and proceeded directly to IVF cycles",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DIETARY_SUPPLEMENT","Melatonin","In the study group, patients will receive melatonin supplementation for at least two months prior to IVF cycles",[9],[26],{"name":27,"affiliation":5,"role":28},"Kuan-Hao Tsui","STUDY_DIRECTOR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},"Li-Te Lin","CONTACT","+88673464027","litelin1982@gmail.com",{"name":27,"role":32,"phone":18,"phoneExt":18,"email":18},[37],{"facility":38,"status":39,"city":40,"state":18,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan","RECRUITING","Kaohsiung City","886","Taiwan","TW",{"type":45,"coordinates":46},"Point",[47,48],120.31333,22.61626,{"lat":48,"lon":47},[51,54],{"name":27,"role":32,"phone":52,"phoneExt":18,"email":53},"+886-7-3422121","lllee23@vghks.gov.tw",{"name":31,"role":55,"phone":18,"phoneExt":18,"email":18},"PRINCIPAL_INVESTIGATOR",{"type":55,"investigatorFullName":31,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Attending doctor, Department of Obstetrics and Gynecology, Principal Investigator, Associate professor","100558104","the-effect-of-melatonin-supplementation-on-cumulus-cells-and-ivf-outcomes-100558104",false,"NCT06546774","The Effect of Melatonin Supplementation on Cumulus Cells and IVF Outcomes","The Effect of Melatonin Supplementation on Cumulus Cells and Reproductive Outcomes in Older Women Undergoing IVF Cycles","Inclusion Criteria:\n\n* Age 35-45 years\n* BMI 18-30 kg\u002Fm2\n* planning to undergo IVF cycles\n\nExclusion Criteria:\n\n* Primary ovarian insufficiency\n* history of oophorectomy\n* receiving oocyte donation\n* Chromosome anomaly\n* Congenital uterine anomaly\n* Severe intrauterine adhesion\n* Malignancy\n* Using hormone therapy or supplements in recent 3 months","FEMALE","35 Years","45 Years",{"count":69,"type":70},200,"ESTIMATED","INTERVENTIONAL",[73],"NA","This study investigates the effects of melatonin supplementation on cumulus cell gene expression and in vitro fertilization (IVF) outcomes in women over 35 years old. In the study group, patients will receive melatonin supplementation for at least two months prior to their IVF cycles. Cumulus cells will be collected after oocyte retrieval, and IVF outcomes will be assessed.",[76],"Unrecognized Condition",[22,78,79,80,81],"Cumulus cells","In vitro fertilization","Old women","Infertility","2024-08-09",{"date":84,"type":85},"2024-08-13","ACTUAL",{"date":87,"type":85},"2021-05-01",{"date":89,"type":70},"2025-12-31",{"name":5,"class":6},1]