[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640547":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":54,"collaborators":26,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":26,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":82,"whyStopped":26,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Serratus Posterior Superior Intercostal Plane (SPSIP) block","EXPERIMENTAL","Participants assigned to this group will receive an ultrasound-guided Serratus Posterior Superior Intercostal Plane (SPSIP) block before induction of general anesthesia for modified radical mastectomy surgery. The block will be performed under sterile conditions by an experienced anesthesiologist using ultrasound guidance. Following the regional block procedure, standardized general anesthesia and postoperative multimodal analgesia protocols will be applied. Postoperative pain scores, opioid consumption, rescue analgesic requirements, and perioperative adverse events will be recorded and evaluated.",[13],"Procedure: Serratus Posterior Superior Intercostal Plane Block",{"label":15,"type":16,"description":17,"interventionNames":18},"Serratus Anterior Plane (SAP) block","ACTIVE_COMPARATOR","Participants assigned to this group will receive an ultrasound-guided Serratus Anterior Plane (SAP) block before induction of general anesthesia for modified radical mastectomy surgery. The block will be performed under sterile conditions by an experienced anesthesiologist using ultrasound guidance. Following the regional block procedure, standardized general anesthesia and postoperative multimodal analgesia protocols will be applied. Postoperative pain scores, opioid consumption, rescue analgesic requirements, and perioperative adverse events will be recorded and evaluated.",[19],"Procedure: Serratus anterior plane block (SAP)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Serratus Posterior Superior Intercostal Plane Block","Ultrasound-guided Serratus Posterior Superior Intercostal Plane (SPSIP) block performed preoperatively for postoperative analgesia in modified radical mastectomy surgery.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Serratus anterior plane block (SAP)","Ultrasound-guided Serratus Anterior Plane (SAP) block performed preoperatively for postoperative analgesia in modified radical mastectomy surgery.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Dilek Metin Yamac, MD","CONTACT","+905054959792","ddilekmetin@hotmail.com",[38],{"facility":39,"status":26,"city":40,"state":41,"zip":42,"country":43,"countryCode":26,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Health Sciences University 2. Sultan Abdülhamid Han Training and Research Hospital","Istanbul","Uskudar","34668","Turkey (Türkiye)",{"type":45,"coordinates":46},"Point",[47,48],28.94966,41.01384,{"lat":48,"lon":47},[51],{"name":52,"role":34,"phone":53,"phoneExt":26,"email":36},"Dilek Metin Yamac, Medicine Doctor","+90216 542 20 00",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Dilek Yamac","MD","100640547","the-effect-of-nerve-blocks-on-analgesia-in-breast-cancer-surgery-100640547",false,"NCT07601490","The Effect of Nerve Blocks on Analgesia in Breast Cancer Surgery","Comparison of Postoperative Analgesic Efficacy of Serratus Posterior Superior Intercostal Plane Block and Serratus Anterior Plane Block in Modified Radical Mastectomy Surgery","breast surgery","Inclusion Criteria:\n\n* Female patients aged between 18 and 65 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Body Mass Index (BMI) \\\u003C35 kg\u002Fm²\n* Normal International Normalized Ratio (INR) value and platelet count\n* Normal liver and renal function tests\n* Patients scheduled for elective modified radical mastectomy surgery\n\nExclusion Criteria:\n\n* Bleeding diathesis\n* Allergy to local anesthetic agents\n* Suspected infection or inflammation at the planned block site\n* ASA physical status IV or higher\n* Long-term medication use due to chronic pain\n* Advanced hepatic or renal failure\n* Presence of severe pulmonary disease\n* Use of any opioid medication within 24 hours before surgery\n* Cognitive impairment\n* Patients undergoing revision surgery","FEMALE","18 Years","65 Years",{"count":70,"type":71},70,"ESTIMATED","INTERVENTIONAL",[74],"NA","Postoperative pain following modified radical mastectomy remains a significant clinical concern and may adversely affect patient recovery, opioid consumption, and overall patient satisfaction. Ultrasound-guided regional anesthesia techniques have gained increasing importance as part of multimodal analgesia strategies in breast surgery. The serratus anterior plane (SAP) block is a commonly used interfascial plane block for postoperative analgesia in thoracic and breast procedures. Recently, the serratus posterior superior intercostal plane (SPSIP) block has emerged as a novel regional anesthesia technique with potentially wider thoracic dermatomal spread and effective analgesic properties.\n\nThis prospective randomized controlled study aims to compare the postoperative analgesic efficacy of the SPSIP block and SAP block in patients undergoing modified radical mastectomy under general anesthesia. Patients will be randomly allocated into two groups to receive either ultrasound-guided SPSIP block or SAP block preoperatively. Primary outcomes will include postoperative pain scores and opioid consumption within the first 24 hours after surgery. Secondary outcomes will include time to first analgesic request, rescue analgesic requirements, intraoperative hemodynamic parameters, postoperative nausea and vomiting, block-related complications, and patient satisfaction.\n\nThe study is designed to evaluate whether SPSIP block provides superior postoperative analgesia compared with SAP block in modified radical mastectomy surgery.",[77],"Breast Cancer Surgery Pain",[79,23,80,81],"modified radical mastectomy","Serratus Anterior Plane Block","Postoperative analgesia","NOT_YET_RECRUITING","2026-05-22",{"date":85,"type":86},"2026-05-27","ACTUAL",{"date":88,"type":71},"2026-06-15",{"date":90,"type":71},"2026-10-16",{"name":5,"class":6},1]