[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642327":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":18,"responsibleParty":34,"collaborators":36,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":18,"eligibilityCriteria":48,"healthyVolunteers":44,"sex":49,"minAge":50,"maxAge":18,"enrollmentInfo":51,"targetDuration":18,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":18,"overallStatus":60,"whyStopped":18,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":18},{"fullName":5,"class":6},"Anglia Ruskin University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise","EXPERIMENTAL","Participants in the intervention group will perform treadmill retro walking exercise 3 days\u002Fweek for 6 weeks.",[13],"Other: Retro walking (backwards walking) on a treadmill",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","NO_INTERVENTION","Participants in the control group will maintain their existing level of activity.",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Retro walking (backwards walking) on a treadmill","Prior to the intervention participants will be made familiar with retro walking on the treadmill. The exercise will consist of a forward walking for 5min on the treadmill for warm-up followed by retro walking for 10min and a cool-down for 5min. Participants will be instructed to increase their retro walking time up to 30min if the pain sensation continuously was reduced (pain scores \\\u003C 3 numerical rating scale).\n\nThe comfortable speed of the retro walking will be determined by the participant under supervision of the researchers. No slopes or inclination will be used in this study for participant safety. In the warm-up and cool-down sessions participants will be asked to perform muscle stretch, ankle toe movements and heel raise exercises.",[9],[9],[26,31],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},"Hasmik J Samvelyan, PhD","CONTACT","+441245683738","jasmine.samvelyan@aru.ac.uk",{"name":32,"role":28,"phone":18,"phoneExt":18,"email":33},"Nathan Bytheway, MEng","NB941@pgr.aru.ac.uk",{"type":35,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[37,39],{"name":38,"class":6},"Cambridge University Hospitals NHS Foundation Trust",{"name":40,"class":41},"Nuffield Health","UNKNOWN","100642327","the-effect-of-physical-activity-on-knee-osteoarthritis-pain-and-gait-100642327",false,"NCT07649863","The Effect of Physical Activity on Knee Osteoarthritis, Pain and Gait","The Effect of Retro Walking on Pain and Gait Biomechanics Using Non-linear Analysis in People With Knee Osteoarthritis","Inclusion Criteria:\n\n* Male and female\n* Any ethnicity\n* Adults over 18 years old\n* Meet the UK guidelines for physical activity supported by NICE (National Institute for Health and Care Excellence) and NHS (able to exercise if it is safe with regular breaks)\n* Otherwise, adults with clinically diagnosed knee osteoarthritis according to NICE criteria or confirmed by a healthcare professional able and willing to participate and provide written informed consent\n\nExclusion Criteria:\n\n* Any musculoskeletal injury\n* Any conditions known to affects gait (e.g. Parkinson's disease or stroke)\n* Any surgical intervention in the previous 12 months on lower limbs\n* Surgical replacement of hip or knee joints\n* BMI (body mass index) over 35\n* Athletes or take part in significant recreational activity\n* Takes any medication known to affect the gait and ability to walk\n* Received an intra-articular injection in the last 3 months\n* Have been told by medical professionals that they should not take part in any intensity exercise\u002Fphysical activity","ALL","18 Years",{"count":52,"type":53},44,"ESTIMATED","INTERVENTIONAL",[56],"NA","Knee osteoarthritis, a chronic musculoskeletal disease, is the most prevalent type of osteoarthritis and the leading cause of disability and major healthcare costs worldwide. The pathogenesis of the disease is not fully understood and there are few non-invasive disease-modifying therapies available to patients. Therefore, there is a critical need to enhance therapeutic interventions, which requires improvement of our understanding of knee osteoarthritis pathogenesis.\n\nIncreasing evidence suggests that physical activity and exercise training are cost-effective and widely available interventions for the treatment of knee osteoarthritis, however, consideration of type of physical activity and optimal exercise modality are needed to reduce pain, improve gait, knee joint function, stiffness, and muscle weakness in individuals with knee osteoarthritis.\n\nThe aim of this pilot clinical trial is to compare individuals with knee osteoarthritis who have not exercised with individuals that have performed retro walking exercise chosen from the systematic review and survey we have conducted previously to reduce pain and improve gait.\n\nNon-linear analyses will be performed to determine the effects of exercise intervention on gait biomechanics and stability of movement in these patients. These findings may form a basis for recommendations of exercise\u002Fphysical activity interventions for the benefits of patients with knee osteoarthritis including pain reduction, mobility improvement and gait modification.",[59],"Osteoarthritis (OA) of the Knee","NOT_YET_RECRUITING","2026-06-11",{"date":63,"type":64},"2026-06-16","ACTUAL",{"date":66,"type":53},"2026-07",{"date":68,"type":53},"2026-12",{"name":5,"class":6}]