[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100481829":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":29,"locations":38,"responsibleParty":55,"collaborators":57,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":23,"enrollmentInfo":69,"targetDuration":23,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":41,"whyStopped":23,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Lund University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A - Supervised exercise first","ACTIVE_COMPARATOR","All POTS patients will continuously be randomized into two groups (Group A and B). Group A will first start the training program and when the training program is finished group B will start the training program. While each group is not performing the training program the patients will be encouraged to physical activity according to their own abilities.\n\nResults from questionnaires, orthostatic tests and maximal biking tests will be compared between group A and B as well as within each group.",[13],"Other: Training program",{"label":15,"type":10,"description":16,"interventionNames":17},"Group B - Self-instruction exercise first","See above.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"Training program","A 16-week training program consisting of 2-3 visits per week, and 60 minutes per visit. The program will be done as group exercise under supervision from physiotherapists and\u002For physicians with special interest in POTS.",[9,15],null,[25],{"name":26,"affiliation":27,"role":28},"Viktor Hamrefors, MD, PhD","Department of Clinical Sciences, Lund University; Department of Cardiology Skåne University Hospital","STUDY_DIRECTOR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":23,"email":34},"Isabella Kharraziha, MD","CONTACT","+46702941194","isabella.kharraziha@med.lu.se",{"name":26,"role":32,"phone":36,"phoneExt":23,"email":37},"+46703996529","viktor.hamrefors@med.lu.se",[39],{"facility":40,"status":41,"city":42,"state":23,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Skånes Universitetssjukhus Malmö, Department of Cardiology","RECRUITING","Malmö","214 28","Sweden","SE",{"type":47,"coordinates":48},"Point",[49,50],13.00073,55.60587,{"lat":50,"lon":49},[53,54],{"name":31,"role":32,"phone":33,"phoneExt":23,"email":34},{"name":26,"role":32,"phone":23,"phoneExt":23,"email":37},{"type":56,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR",[58],{"name":59,"class":6},"Region Skane","100481829","the-effect-of-physical-activity-on-postural-orthostatic-tachycardia-syndrome-100481829",false,"NCT05554107","The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome","POTS","Inclusion Criteria:\n\n* Patients diagnosed with POTS who have given written informed consent for participation in the study.\n\nExclusion Criteria:\n\n* Patients with myalgic encephalomyelitis are excluded from the study.","ALL","18 Years",{"count":70,"type":71},200,"ESTIMATED","INTERVENTIONAL",[74],"NA","Postural orthostatic tachycardia syndrome (POTS) is a disorder of unknown origin characterized by orthostatic intolerance and increased heart rate (HR) of ≥ 30 beats\u002Fminute during orthostasis in the absence of orthostatic hypotension. In addition to the orthostatic intolerance and tachycardia, patients with POTS experience several debilitating symptoms including light-headedness, nausea, blurred vision, fatigue, mental confusion (\"brain-fog\"), chest pain and gastrointestinal problems. Several potential underlying mechanisms have been suggested for POTS including autonomic denervation, hypovolemia, hyperadrenergic stimulation and autoantibodies against adrenergic receptors. However, none of these proposed mechanisms has yet led to an effective treatment. Physical activity is recommended as a complimentary treatment in POTS in international guidelines. However, less is known regarding how physical activity could successfully be implemented in clinical practice in patients with POTS. Thus, in the current study, we aim to assess the effect of a 16-week specialized physical activity program in POTS.",[77],"POTS - Postural Orthostatic Tachycardia Syndrome",[79,65,80,81,82],"Exercise","Training programme","Treatment","Orthostatic intolerance","2025-05-26",{"date":85,"type":86},"2025-05-30","ACTUAL",{"date":88,"type":86},"2022-11-02",{"date":90,"type":71},"2028-10",{"name":5,"class":6},1]