[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100531749":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":58,"collaborators":26,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":62,"sex":68,"minAge":69,"maxAge":26,"enrollmentInfo":70,"targetDuration":26,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":81,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"National Taiwan University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention group","EXPERIMENTAL","Combined drug treatment: includes epinephrine (Adrenaline® 1mg\u002Fvial) every 3-5 minutes, vasopressin (Pitressin® 20Unints\u002Fvial) every 3-5 minutes up to 4 vials (a total of 80Units), methylprednisolone (Solu-Medrol® 40mg\u002Fvial).\n\nThe method of administration is as follows: after the first administration of epinephrine (Adrenaline® 1mg\u002Fvial) to patients with cardiac arrest before hospital arrival, vasopressin (Pitressin® 20Unints\u002Fvial) and methylprednisolone (Solu-Medrol® 40mg\u002Fvial) are given simultaneously; thereafter, every 3-5 minutes, 1 mg (1 dose) of (Adrenaline® 1mg\u002Fvial) is given, along with 20 Units (1 dose) of vasopressin (Pitressin® 20Unints\u002Fvial) up to a maximum of 4 doses (a total of 80 Units) of vasopressin can be given before hospital arrival.",[13],"Drug: Combination group",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","ACTIVE_COMPARATOR","Standard drug treatment: epinephrine (Adrenaline® 1mg\u002Fvial). According to international resuscitation guidelines ( Advanced Cardiac Life Support, ACLS), patients with cardiac arrest before hospital arrival are given 1 mg (1 dose) of epinephrine (Adrenaline® 1mg\u002Fvial) every 3-5 minutes.",[19],"Drug: Standard group",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Combination group","Combination of epinephrine (Adrenaline® 1mg\u002Fvial) every 3-5 minutes, vasopressin (Pitressin® 20Unints\u002Fvial) every 3-5 minutes up to 4 vials (a total of 80Units), methylprednisolone (Solu-Medrol® 40mg\u002Fvial)",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Standard group","standard doses of epinephrine (Adrenaline® 1mg\u002Fvial) every 3-5 minutes",[15],[32],{"name":33,"affiliation":5,"role":34},"WEN CHU CHIANG, Phd","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"WEN CHU CHIANG, PhD","CONTACT","+886 926131851","drchiang.tw@gmail.com",[42],{"facility":5,"status":43,"city":44,"state":26,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"RECRUITING","Taipei","100","Taiwan","TW",{"type":49,"coordinates":50},"Point",[51,52],121.52639,25.05306,{"lat":52,"lon":51},[55],{"name":56,"role":38,"phone":57,"phoneExt":26,"email":40},"Wen-Chu Chiang, MD, PhD","886-2-23123456",{"type":59,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100531749","the-effect-of-prehospital-combination-of-epinephrine-vasopressin-and-steroid-in-ohca-100531749",false,"NCT06203847","The Effect of Prehospital Combination of Epinephrine, Vasopressin, and Steroid in OHCA","A Randomized Clinical Trial of Patient Outcomes Following Out-of-Hospital Cardiac Arrest Receiving Epinephrine Versus In-together Vasopressin, Epinephrine, and Steroid. (OHCA REVIVES Trial)","REVIVES","Inclusion Criteria:\n\n* Adult patients (aged \\>= 18 )\n* Out-of-hospital cardiac arrest in the studied regions\n* Treated by paramedics authorized and capable of giving prehospital medication\n\nExclusion Criteria:\n\n* OHCA with traumatic etiology\n* Obvious signs of death like decapitation, rigor mortis, livor mortis, decomposition, etc.\n* DNR (Do Not Resuscitation) or termination of resuscitation requested by the family\n* Patients with known or suspected pregnancy\n* No vascular access was established before hospital arrival\n* ROSC before the administrated medication\n* No patient contact (cancelled ambulance call or the patient was transported to the hospital before the arrival of trial-trained paramedics)\n* Received epinephrine prior to the arrival of trial-trained paramedics","ALL","18 Years",{"count":71,"type":72},1344,"ESTIMATED","INTERVENTIONAL",[75],"NA","This project is a randomized controlled clinical research design, The hypothesis P-I-C-O of the study is: For adult patients in the Taipei City and New Taipei City communities who have suffered sudden non-traumatic death and have been resuscitated by advanced paramedics, the intervention group that receives combined drug treatment (epinephrine, vasopressin, methylprednisolone) has a better rate of sustained recovery of spontaneous circulation (ROSC) (primary outcome) and long-term survival status (secondary outcomes) compared to the control group that receives single drug treatment (epinephrine).",[78,79,80],"Cardiac Arrest","Out-Of-Hospital Cardiac Arrest","Emergency Medical Services",[79,80,82,83,84],"Corticosteroid","Epinephrine","Vasopressin","2025-11-16",{"date":87,"type":88},"2025-11-19","ACTUAL",{"date":90,"type":88},"2024-07-16",{"date":92,"type":72},"2026-12-31",{"name":5,"class":6},1]