[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631350":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":20,"responsibleParty":31,"collaborators":20,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":37,"acronym":38,"eligibilityCriteria":39,"healthyVolunteers":35,"sex":40,"minAge":41,"maxAge":20,"enrollmentInfo":42,"targetDuration":20,"studyType":45,"phases":46,"briefSummary":48,"conditions":49,"keywords":52,"overallStatus":54,"whyStopped":20,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":62,"locationsCount":20},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Atrial ablation including at least pulmonary vein isolation and posterior wall isolation","EXPERIMENTAL","The intervention under investigation is pulse-field ablation (PFA) which is a non-thermal energy based on high voltage, ultra-short energy pulses applied selectively to cardiomyocytes.",[13],"Procedure: Atrial fibrillation ablation procedure planned using pulsed-field ablation and including at least pulmonary vein isolation and posterior wall isolation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Atrial fibrillation ablation procedure planned using pulsed-field ablation and including at least pulmonary vein isolation and posterior wall isolation","Persistent or paroxysmal atrial fibrillation treated by pulse-field ablation. Interventions added by the study are cardiac MRI (pre-ablation and 4 months after ablation) with administration of contrast agent (Dotarem®).",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Houria Mebarek","STUDY_DIRECTOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":20,"email":30},"Mikael Laredo, MD, PhD","CONTACT","+33 1 84 82 76 20","mikael.laredo@aphp.fr",{"type":32,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100631350","the-effect-of-pulse-field-ablation-of-atrial-fibrillation-involving-posterior-wall-ablation-on-atrial-mechancis-assessed-by-cardiac-magnetic-resonance-imaging-100631350",false,"NCT07499531","The Effect of Pulse Field Ablation of Atrial Fibrillation Involving Posterior Wall Ablation on Atrial Mechancis Assessed by Cardiac Magnetic Resonance Imaging","PF-MRI+","Inclusion Criteria:\n\n* Patient age ≥ 18\n* Established diagnosis of persistent or paroxysmal atrial fibrillation with a I\u002FIIa\u002FIIb indication for catheter ablation (ESC 2020 guidelines)\n* AF ablation procedure planned using pulsed-field ablation and including at least pulmonary vein isolation and posterior wall isolation\n* Episode of AF documented by ECG within the last 12 months\n* Patient able to give written informed consent\n* If female of childbearing potential, have a negative serum pregnancy test and using effective contraception\n* Be affiliated with a French social security system or entitled\n\nExclusion Criteria:\n\n* Only pulmonary vein isolation is scheduled\n* Atrial fibrillation present at ECG during the pre-ablation (V1a) visit\n* Contraindication to oral anticoagulation\n* Intracardiac thrombus\n* Previous ablation in the left atrium\n* Previous heart surgery\n* Significant valvular heart disease defined as any moderate (grade 3) or severe (grade 4) mitral regurgitation, mitral stenosis, aortic regurgitation, aortic stenosis, tricuspid regurgitation, or tricuspid stenosis\n* Contraindication to perform MRI or using the DOTAREM™ contrast product (pacemaker, defibrillator, foreign body or prosthesis, old generation heart valves, old generation ferromagnetic vascular surgical clips, percutaneous devices for endocranial aneurysms, neurosimulator, cochlear implants, automated injection device such as insulin pump, and more generally any non-removable electronic device, severe kidney disease with GFR \\\u003C 30 mL\u002Fmin, documented hypersensitivity to gadoteric acid or to excipients, severe claustrophobia)\n* Patient on AME (state medical aid)\n* Pregnant or breast-feeding female\n* Patient protected by law (guardianship, tutelage measure, deprived of liberty)\n* Participation in another interventional study or being in the exclusion period at the end of a previous study.","ALL","18 Years",{"count":43,"type":44},39,"ESTIMATED","INTERVENTIONAL",[47],"NA","Assessing the impact of a new atrial fibrillation (AF) catheter ablation energy on left atrial structure and function is of crucial importance.\n\nThe goal of this clinical trial is to assess the effect of pulsed-field ablation of atrial fibrillation on left atrial structure.",[50,51],"Persistant Atrial Fibrillation","Paroxysmal AF",[53],"Catheter Ablation","NOT_YET_RECRUITING","2026-03-24",{"date":57,"type":58},"2026-03-30","ACTUAL",{"date":60,"type":44},"2026-04",{"date":60,"type":44},{"name":5,"class":6}]