[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100597751":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":31,"centralContacts":45,"locations":51,"responsibleParty":69,"collaborators":31,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":31,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":53,"whyStopped":31,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Wageningen University","OTHER",[8,15,21],{"label":9,"type":10,"description":11,"interventionNames":12},"Control group","SHAM_COMPARATOR","Sham-NMES with standard nutrition",[13,14],"Other: Sham (No Treatment)","Other: Standard nutrition",{"label":16,"type":17,"description":18,"interventionNames":19},"Whole-body NMES group","ACTIVE_COMPARATOR","Whole-body NMES stimulation with standard nutrition",[20,14],"Other: NMES",{"label":22,"type":17,"description":23,"interventionNames":24},"Whole-body NMES + protein group","Whole-body NMES with a 20g protein bolus on top of the standard nutrition",[20,25,14],"Dietary Supplement: Protein bolus (20g)",[27,32,36,41],{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Sham (No Treatment)","A placebo treatment in which no actual electrical stimulation is delivered, serving as a control for the active NMES.",[9],null,{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"NMES","Active neuromuscular electrical stimulation applied to the entire body to induce muscle contractions through small electric currents.",[22,16],{"type":37,"name":38,"description":39,"armGroupLabels":40,"otherNames":31},"DIETARY_SUPPLEMENT","Protein bolus (20g)","A bolus dose of 20 grams of protein provided after the NMES intervention to assess the combined effect of muscle stimulation and protein intake on muscle protein metabolism.",[22],{"type":6,"name":42,"description":43,"armGroupLabels":44,"otherNames":31},"Standard nutrition","Provision of a normal Western standardized diet.",[9,22,16],[46],{"name":47,"role":48,"phone":49,"phoneExt":31,"email":50},"Marlou Dirks, PhD","CONTACT","+31 317 480 100","marlou.dirks@wur.nl",[52],{"facility":5,"status":53,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"RECRUITING","Wageningen","Gelderland","6708WD","Netherlands","NL",{"type":60,"coordinates":61},"Point",[62,63],5.66667,51.97,{"lat":63,"lon":62},[66,67],{"name":47,"role":48,"phone":49,"phoneExt":31,"email":50},{"name":47,"role":68,"phone":31,"phoneExt":31,"email":31},"PRINCIPAL_INVESTIGATOR",{"type":68,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"Marlou Dirks","Assistant Professor","100597751","the-effect-of-repeated-whole-body-nmes-sessions-with-or-without-protein-intake-on-muscle-protein-synthesis-during-3-days-of-bed-rest-in-healthy-young-volunteers-100597751",false,"NCT07062562","The Effect of Repeated Whole-body NMES Sessions With or Without Protein Intake on Muscle Protein Synthesis During 3 Days of Bed Rest in Healthy Young Volunteers","The Effect of Repeated Sessions of Whole-body Neuromuscular Electrical Stimulation (NMES), With or Without Subsequent Intake of a Protein Bolus, on Muscle Protein Synthesis in Healthy, Young Volunteers During 3 Days of Bed Rest","SPRINT","Inclusion Criteria:\n\n* Aged from 18-35 years\n* 18.5 \\\u003C BMI \\\u003C 30 kg·m2\n* Recreationally active (performing non-competitive physical exercise at least one time per week for minimally 30 minutes)\n\nExclusion Criteria:\n\n* Employed or undertaking a thesis or internship at the department of Human and Animal Physiology at Wageningen University\n* Smoking\n* Diabetes (Type 1, Type 2, or genetic form of diabetes)\n* Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and\u002For\n\n  ≥90 mmHg diastolic)\n* Chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices)\n* Known allergy to lidocaine\n* Prone to keloid forming (i.e. hyperplastic growth of scars)\n* All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g.\n\narthritis, spasticity\u002Frigidity, all neurological disorders and paralysis)\n\n* Regular use of dietary protein and\u002For amino acid supplements (\\>3 times per week)\n* Currently involved in a structured progressive resistance training programme (\\>3 times per week)\n* A personal or family history of thrombosis (clots), epilepsy, seizures, or schizophrenia\n* Any previous motor disorders or disorders in muscle and\u002For lipid metabolism\n* Any back, leg, knee, neck, shoulder or postural complaints\n* Presence of an ulcer in the stomach or gut and\u002For strong history of indigestion\n* Contra-indications for DXA scans (e.g. undergoing radiologic examination)\n* Lactose intolerance\n* Known severe kidney problems\n* Pregnant or breastfeeding\n* Unable to give consent",true,"ALL","18 Years","35 Years",{"count":85,"type":86},42,"ESTIMATED","INTERVENTIONAL",[89],"NA","The goal of this clinical trial is to examine the effect of whole-body electrostimulation with protein intake on muscle protein synthesis, muscle mass and function during bed rest in healthy young adults (18-35 years). The main questions to answer are:\n\n* Does whole-body NMES followed by protein intake improve muscle protein synthesis rates during 3 days of bed rest?\n* Does repeated NMES sessions offer protective effects on muscle mass and function during extended periods of inactivity?\n\nResearchers will compare sham electrical electrostimulation, electrical stimulation and electrical stimulation + protein groups to see if whole-body electrostimulation combined with protein intake offers the greatest improvement in muscle protein metabolism and muscle preservation.\n\nParticipants will:\n\n* Undergo 3 days of bed rest while receiving one of the following interventions:\n\n  * Sham-NMES followed by standard nutrition (CON)\n  * Whole-body NMES followed by standard nutrition(NMES)\n  * Whole-body NMES followed by a bolus of 20g protein (NMES+PRO)\n* Receive heavy water (D2O) to assess body water turnover.\n* Undergo leg extension exercises to assess muscle function.\n* Have quadriceps muscle thickness measured via ultrasound.\n* Provide saliva samples for analysis.\n* Have calf circumference measured to monitor changes in muscle mass.",[92],"Muscle Wasting",[33,94,95,96],"Skeletal Muscle Metabolism","Protein","Disuse","2025-07-09",{"date":99,"type":100},"2025-07-14","ACTUAL",{"date":102,"type":100},"2025-05-22",{"date":104,"type":86},"2027-05",{"name":5,"class":6},1]