[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100482386":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":32,"centralContacts":36,"locations":42,"responsibleParty":58,"collaborators":10,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":10,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":10,"studyType":73,"phases":10,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":45,"whyStopped":10,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Second Affiliated Hospital of Nanchang University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"SAAE group",null,"Subjects received super selective adrenal artery embolization treatment",[13],"Procedure: Super selective adrenal artery embolization",{"label":15,"type":10,"description":16,"interventionNames":17},"Spironolactone group","Subjects received spironolactone treatment",[18],"Drug: Spironolactone",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Super selective adrenal artery embolization","Superselective adrenal arterial embolization is an operation to inject embolic agent into adrenal artery through catheter to embolize part of adrenal gland, so as to reduce the secretion of adrenal hormone and reduce blood pressure.",[9],[26],"SAAE",{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":10},"DRUG","Spironolactone","Aldosterone receptor antagonists are recommended by guidelines for the treatment of bilateral primary aldosteronism.",[15],[33],{"name":34,"affiliation":5,"role":35},"Yifei Dong","STUDY_DIRECTOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":10,"email":41},"Yifei Dong, Doctorate","CONTACT","+8613576007061","yf_dong66@126.com",[43],{"facility":44,"status":45,"city":46,"state":10,"zip":10,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"The Second Affiliated Hospital of Nanchang University","RECRUITING","Nanchang","China","CN",{"type":50,"coordinates":51},"Point",[52,53],115.85306,28.68396,{"lat":53,"lon":52},[56],{"name":57,"role":39,"phone":40,"phoneExt":10,"email":41},"Yifei Dong, doctorate",{"type":59,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100482386","the-effect-of-saae-on-vascular-endothelial-function-in-pa-patients-100482386",false,"NCT05561361","The Effect of SAAE on Vascular Endothelial Function in PA Patients","The Effect of Selective Adrenal Artery Embolism on Vascular Endothelial Function in Patients With Primary Aldosteronism Based on Brachial Artery Flow-mediated Relaxation","Inclusion Criteria:\n\n* (1)Aged 18-75 years, males and females;\n* (2)Blood pressure ≥ 140\u002F90 mmHg on at least three non-same-day office visits without antihypertensive medication or 24-hour ambulatory blood pressure averaging \\>130\u002F80 mmHg throughout the day or averaging \\>135\u002F85 mmHg during the day;\n* (3)Primary aldosteronism was diagnosed in accordance with the 2016 international society of Endocrinology clinical guidelines after strict drug elution;\n* (4)Contraindications to spironolactone-free administration;\n* (5)No surgical intention or surgical contraindications, and willing to accept drug treatment or percutaneous superselective adrenal artery embolization;\n* (6)The anatomy of adrenal arteriography is suitable for selective adrenal artery embolization.\n\nExclusion Criteria:\n\n* (1)Secondary hypertension of other causes;\n* (2)Pregnant women or those who have a fertility plan in the next year;\n* (3)Glomerular filtration rate EGFR \\\u003C 45 ml\u002Fmin\u002F1.73m\\^2;\n* (4)History of severe contrast allergy;\n* (5)Hyperkalemia;\n* (6)Patients with other serious organic diseases or life expectancy \\\u003C 12 months can not tolerate the treatment of super selective adrenal artery embolizatio;\n* (7)The diameter of adrenal space occupying lesions was more than 2 cm;\n* (8)A history of myocardial infarction, syncope, cerebral hemorrhage or cerebral infarction within 3 months before the informed consent;\n* (9)The results of this study will be affected during the period when patients are enrolled or will participate in other clinical studies.","ALL","18 Years","75 Years",{"count":71,"type":72},200,"ESTIMATED","OBSERVATIONAL","The study aims to assess the effect of superselective adrenal arterial embolization on vascular endothelial function in patients with primary aldosteronism based on brachial artery flow-mediated relaxation",[76],"Primary Aldosteronism",[78,79,80],"primary aldosteronism","selective adrenal artery embolization","vascular endothelial function","2025-12-07",{"date":83,"type":84},"2025-12-15","ACTUAL",{"date":86,"type":84},"2022-10-01",{"date":88,"type":72},"2026-12-31",{"name":5,"class":6},1]