[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100477754":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":40,"responsibleParty":53,"collaborators":25,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":25,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":25,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":43,"whyStopped":25,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Second Affiliated Hospital of Nanchang University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"SAAE group","EXPERIMENTAL","Subjects received super selective adrenal artery embolization treatment",[13],"Other: Super selective adrenal artery embolization",{"label":15,"type":16,"description":17,"interventionNames":18},"Spironolactone group","ACTIVE_COMPARATOR","Subjects received spironolactone treatment",[19],"Drug: Spironolactone",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Super selective adrenal artery embolization","Superselective adrenal arterial embolization is an operation to inject embolic agent into adrenal artery through catheter to embolize part of adrenal gland, so as to reduce the secretion of adrenal hormone and reduce blood pressure.",[9],null,{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":25},"DRUG","Spironolactone","Aldosterone receptor antagonists are recommended by guidelines for the treatment of bilateral primary aldosteronism.",[15],[32],{"name":33,"affiliation":5,"role":34},"Yifei Dong, Doctorate","STUDY_DIRECTOR",[36],{"name":33,"role":37,"phone":38,"phoneExt":25,"email":39},"CONTACT","+8613576007061","yf_dong66@126.com",[41],{"facility":42,"status":43,"city":44,"state":25,"zip":25,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":25},"The Second Affiliated Hospital of Nanchang University","RECRUITING","Nanchang","China","CN",{"type":48,"coordinates":49},"Point",[50,51],115.85306,28.68396,{"lat":51,"lon":50},{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Yifei Dong","Professor","100477754","the-effect-of-saae-on-ventricular-remodeling-in-pa-patients-100477754",false,"NCT05501080","The Effect of SAAE on Ventricular Remodeling in PA Patients","The Effect of Selective Adrenal Artery Embolization and Spironolactone on Ventricular Remodeling in Nondominant Lateral Secretory Primary Aldosteronism： A Randomized Controlled Clinical Study","Inclusion Criteria:\n\n* (1) Age 18-60 years old, regardless of gender;\n* (2) Blood pressure conditions meet one of the following: 1) Office blood pressure ≥ 140\u002F90mmHg; 2) Ambulatory blood pressure monitoring whole day blood pressure \\> 130\u002F80 mmHg or daytime blood pressure \\> 135\u002F85 mmHg;\n* (3) After strict drug elution, it met the diagnostic criteria of primary aldosteronism, and bilateral primary aldosteronism was confirmed by adrenal venous sampling;\n* (4) No surgical intent or contraindication to surgery and willing to undergo pharmacological treatment or percutaneous superselective adrenal artery embolization;\n* (5) The patient or his\u002Fher legal representative shall sign the written informed consent approved by the ethics committee before the screening.\n\nExclusion Criteria:\n\n* (1) Primary hypertension or secondary hypertension with other causes;\n* (2) A woman who is pregnant or lactating, or has a birth plan for the next year;\n* (3) There are serious organic diseases, especially liver and kidney dysfunction(eGFR\\\u003C45 mL\u002Fmin\u002F1.73 m2);\n* (4) Severe allergy to contrast medium;\n* (5) Other serious organic diseases, life expectancy \\\u003C 12 months;\n* (6) Adrenal CT showed adenoma.;\n* (7) Patients are enrolled or want to participate in other clinical studies. During the enrollment study, the results of this study will be affected.","ALL","18 Years","60 Years",{"count":68,"type":69},112,"ESTIMATED","INTERVENTIONAL",[72],"NA","The study aims to assess the effect of superselective adrenal arterial embolization on ventricular remodeling in primary aldosteronism without lateralized aldosterone secretion by comparing it with spironolactone therapy.",[75],"Primary Aldosteronism",[77,78,79,80,81],"primary aldosteronism","selective adrenal artery embolization","bilateral primary aldosteronism","Nondominant Lateral Secretory Primary Aldosteronism","Ventricular Remodeling","2025-05-13",{"date":84,"type":85},"2025-05-16","ACTUAL",{"date":87,"type":85},"2022-09-01",{"date":89,"type":69},"2025-12-31",{"name":5,"class":6},1]