[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100466245":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":19,"centralContacts":23,"locations":28,"responsibleParty":45,"collaborators":10,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":10,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":10,"maxAge":56,"enrollmentInfo":57,"targetDuration":10,"studyType":60,"phases":10,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":30,"whyStopped":10,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Children's Hospital of Fudan University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Cases",null,"Individuals diagnosed with KHE and treated with sirolimus. After immunoglobulin and flow cytometry assays, as well as outpatient evaluation and assessment, those participants will be vaccinated with live attenuated vaccines or inactivated vaccines in a timely order according to the advice. （Sirolimus Rapamycin 0.8mg\u002Fm2 bid po）",{"label":13,"type":10,"description":14,"interventionNames":10},"Controls","Healthy children with no immunodeficiency disease, vaccinated according to the National Immunization Program. Particpants should be age-matched with the case group.",[16],{"type":6,"name":10,"description":17,"armGroupLabels":18,"otherNames":10},"No intervention",[9,13],[20],{"name":21,"affiliation":5,"role":22},"Kai Li, PhD","PRINCIPAL_INVESTIGATOR",[24],{"name":21,"role":25,"phone":26,"phoneExt":10,"email":27},"CONTACT","02164931114","likai2727@163.com",[29],{"facility":5,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"RECRUITING","Shanghai","Shanghai Municipality","201102","China","CN",{"type":37,"coordinates":38},"Point",[39,40],121.45806,31.22222,{"lat":40,"lon":39},[43],{"name":44,"role":25,"phone":10,"phoneExt":10,"email":10},"Kai Li, Doctor",{"type":46,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100466245","the-effect-of-sirolimus-on-immunizations-during-the-treatment-of-kaposiform-hemangioendothelioma-100466245",false,"NCT05351216","The Effect of Sirolimus on Immunizations During the Treatment of Kaposiform Hemangioendothelioma","The Effect of Sirolimus on Time-sequentially Scheduled Immunizations During the Treatment of Kaposiform Hemangioendothelioma: a Case-control Study","Inclusion Criteria:\n\n* Case groups:\n* KHE patients treated with sirolimus.\n* After immunoglobulin and flow cytometry assays, as well as outpatient evaluation and assessment, those participants will be vaccinated with live attenuated vaccines or inactivated vaccines in a timely order according to the advice.\n* Control groups:\n* Healthy children with no immune deficiencies.\n* Participants are vaccinated according to the National Immunization Program in a timely manner.\n* Participants are matched to the case group according to age.\n\nExclusion Criteria:\n\n* HBsAg, HBeAg positive, or other active infectious diseases;\n* History of immunodeficiency or low immunoglobulin levels;\n* Autoimmune disease or fever during blood collection;\n* Use of other medication or surgery;\n* Suffering from other bleeding disorders;\n* Suffering from other solid tumors or hematological tumors, etc.;\n* Withdraw informed consent.",true,"ALL","12 Years",{"count":58,"type":59},174,"ESTIMATED","OBSERVATIONAL","To research and explore the antibody protection and immune memory after vaccination in children with KHE during sirolimus administration. To explore the feasibility (safety and efficacy) of vaccination in a timely manner during the administration of sirolimus in children with KHE. To search for back-up plans for vaccination regimens for KHE patients taking sirolimus in children who do not respond to primary vaccination.",[63],"Kaposiform Hemangioendothelioma",[65,66],"Following National Vaccination Program","Sirolimus","2025-06-24",{"date":69,"type":70},"2025-06-27","ACTUAL",{"date":72,"type":70},"2021-03-01",{"date":74,"type":59},"2028-03",{"name":5,"class":6},1]