[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100469516":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":27,"centralContacts":31,"locations":37,"responsibleParty":60,"collaborators":12,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":12,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":12,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":85,"overallStatus":39,"whyStopped":12,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Beth Israel Deaconess Medical Center","OTHER",[8,13,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Normal Sleep","NO_INTERVENTION","Normal Sleep - Healthy participants are permitted normal nights of polysomnography or actigraphy recorded sleep before participating in an emotion regulation task during functional Magnetic Resonance Imaging (fMRI) scanning",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Sleep Restriction","ACTIVE_COMPARATOR","Healthy Participants are sleep restricted to 4 hours of sleep for 3 consecutive days before participating in an emotion regulation task during functional Magnetic Resonance Imaging (fMRI) scanning",[18],"Behavioral: Sleep Restriction",{"label":20,"type":10,"description":21,"interventionNames":12},"Patients with Insomnia Disorder","Patients with Insomnia Disorder will also be recruited and will be permitted normal nights of polysomnography or actigraphy recorded sleep before participating in an emotion regulation task during functional Magnetic Resonance Imaging (fMRI) scanning",[23],{"type":24,"name":14,"description":25,"armGroupLabels":26,"otherNames":12},"BEHAVIORAL","Three nights of sleep restricted to 4 hours per night.",[14],[28],{"name":29,"affiliation":5,"role":30},"Janet M Mullington, PhD","PRINCIPAL_INVESTIGATOR",[32],{"name":33,"role":34,"phone":35,"phoneExt":12,"email":36},"Tony J Cunningham, PhD","CONTACT","617-667-3337","acunnin4@BIDMC.Harvard.edu",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Boston","Massachusetts","02215","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-71.05977,42.35843,{"lat":49,"lon":48},[52,56],{"name":53,"role":34,"phone":54,"phoneExt":12,"email":55},"Tony Cunningham, PhD","617-667-4702","acunnin4@bidmc.harvard.edu",{"name":57,"role":34,"phone":58,"phoneExt":12,"email":59},"Janet Mullington, PhD","617-667-0434","jmulling@BIDMC.Harvard.edu",{"type":30,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"Tony Cunningham","Assistant Professor of Psychology in the Department of Psychiatry","100469516","the-effect-of-sleep-loss-on-emotion-regulation-100469516",false,"NCT05393830","The Effect of Sleep Loss on Emotion Regulation","The Impact of Insufficient Sleep and Insomnia Disorder on Behavioral and Neural Markers of Emotion Regulation","Inclusion Criteria:\n\n* willing and able to follow the protocol\n* willing and able to meet inclusion criteria for fMRI scanning\n* willing to refrain from alcohol and recreational drugs for the duration of the protocol\n* normal or corrected to normal vision is required\n\nExclusion Criteria:\n\n* left-handedness or ambidexterity\n* the use of any drugs that could affect either sleep or cognitive functioning (e.g., prescription sleeping pills or antidepressants)",true,"ALL","18 Years","40 Years",{"count":75,"type":76},90,"ESTIMATED","INTERVENTIONAL",[79],"NA","The study is designed to investigate the impact of three nights of sleep restricted to 4 hours per night, on the processing and regulation of emotional information compared to Insomnia Disorder and control. The investigators will address and attempt to answer two questions.\n\n(i) How do three nights of reduced sleep or a diagnosis of Insomnia Disorder affect the processing and regulation of emotional information compared to typical, undisturbed sleep? (ii) What overlapping and distinct neural mechanisms are engaged and associated with behavioral effects when attempting to process and regulate emotions in a sleep restricted state or with a clinical diagnosis of Insomnia Disorder? This study will investigate sleep's role in emotion processing and regulation. The findings will help further understanding of the role of sleep in healthy emotional functioning.",[82,83,84],"Sleep","Insomnia","Sleep Deprivation",[86,14,87,82,88,89],"Emotion","Insomnia Disorder","Emotion Regulation","functional Magnetic Resonance Imaging (fMRI)","2026-04-09",{"date":92,"type":93},"2026-04-14","ACTUAL",{"date":95,"type":93},"2023-05-11",{"date":97,"type":76},"2027-07-31",{"name":5,"class":6},1]