[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641871":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":39,"responsibleParty":52,"collaborators":24,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":24,"enrollmentInfo":64,"targetDuration":24,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":78,"whyStopped":24,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Universität Münster","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Early filter change","EXPERIMENTAL","Scheduled filter change during continuous renal replacement therapy at 36 ± 3 hours.",[13],"Other: time span of filter change",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard of Care filter change","ACTIVE_COMPARATOR","Standard of care with scheduled filter change during continuous renal replacement therapy at 72 hours.",[13],[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"time span of filter change","The time span of the filter change during continuous renal replacement therapy will be specified",[9,15],null,[26],{"name":27,"affiliation":28,"role":29},"Alexander Zarbock, MD","University Hospital Muenster, Dept. of Anesthesiology, Intensive Care Medicine and Pain Therapy","STUDY_CHAIR",[31,35],{"name":27,"role":32,"phone":33,"phoneExt":24,"email":34},"CONTACT","+49-251-8347255","zarbock@uni-muenster.de",{"name":36,"role":32,"phone":37,"phoneExt":24,"email":38},"Nadja Schöne, MD","+49-8347262","nadja.schoene@ukmuenster.de",[40],{"facility":41,"status":24,"city":42,"state":24,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":24},"University Hospital Münster","Münster","48149","Germany","DE",{"type":47,"coordinates":48},"Point",[49,50],7.62571,51.96236,{"lat":50,"lon":49},{"type":53,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100641871","the-effect-of-standard-vs-shorter-filter-lifespan-during-continuous-renal-replacement-therapy-100641871",false,"NCT07630220","The Effect of Standard vs. Shorter Filter Lifespan During Continuous Renal Replacement Therapy","The Effect of Standard vs. Shorter Filter Lifespan During Continuous Renal Replacement Therapy in Critically Ill Patients With Acute Kidney Injury - a Feasibility Randomized Controlled Trial","SPECIAL","Inclusion Criteria:\n\n1. Adult ≥ 18 years\n2. Critically ill patients with severe AKI consistent with KDIGO stage 3 and an absolute indication for CRRT\n3. Written consent form from the patient or legal representative or authorized representative or emergency inclusion\n\nExclusion Criteria:\n\n1. End-stage kidney disease or chronic dialysis dependence\n2. Chronic kidney disease with eGFR\\\u003C20ml\u002Fmin\u002F1.73 m²\n3. Prior kidney transplant\n4. Prior renal replacement therapy during the index admission before randomization\n5. Glomerulonephritis, interstitial nephritis, vasculitis\n6. Patients on immunosuppression (above the cushing threshold)\n7. Patients with chronic inflammatory diseases (e.g. arthritis, HIV with a CD4 count of \\\u003C 0.05 x 10E\u002Fl)\n8. Do-not resuscitate order\n9. Persons with any kind of dependency on the investigator or employed by the sponsor\n10. Patients participating in an interventional study involving measures to influence the immune system","ALL","18 Years",{"count":65,"type":66},100,"ESTIMATED","INTERVENTIONAL",[69],"NA","This study aims to investigate shorter vs. standard filter lifespans in critically ill patients receiving continuous renal replacement therapy (CRRT) for acute kidney injury (AKI). The aim of this trial is to reliably implement,scheduled filter changes and to investigate whether shorter filter lifetime is associated with a lower incidence in rate of new infections.",[72],"Acute Kidney Injury",[74,75,76,77],"Continuous Renal Replacement Therapy (CRRT)","Infection","filter change","critical illness","NOT_YET_RECRUITING","2026-06-10",{"date":81,"type":82},"2026-06-15","ACTUAL",{"date":84,"type":66},"2026-06",{"date":86,"type":66},"2028-06",{"name":5,"class":6},1]