[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613636":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":27,"centralContacts":40,"locations":46,"responsibleParty":57,"collaborators":27,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":27,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":87,"whyStopped":27,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Saglik Bilimleri Universitesi","OTHER",[8,17],{"label":9,"type":10,"description":11,"interventionNames":12},"Study group","EXPERIMENTAL","Patients undergoing right mandibular third molar surgery will receive standard postoperative medication: painkillers (dexketoprofen 25 mg), antibiotics (amoxicillin 875 mg + clavulanic acid 125 mg), and a chlorhexidine 0.12% + benzydamine 0.15% mouthwash. Demographic data will be recorded preoperatively. All surgeries will be performed under sterile conditions with inferior alveolar nerve block and buccal infiltration using articaine 4% with epinephrine 1:100,000. Operation time will be measured from incision to last suture. Osteotomy and, when necessary, tooth sectioning will be performed with a surgical handpiece and saline irrigation. After extraction, sockets will be smoothed and closed with 3-0 silk sutures. Patients will be reviewed on postoperative days 1, 2, 3, and 7, and pain, edema, and trismus will be recorded.",[13,14,15,16],"Procedure: Pain Assessment","Procedure: Number of Analgesics Needed","Procedure: Edema Assessment","Procedure: Trismus Assessment",{"label":18,"type":10,"description":19,"interventionNames":20},"Control group","Patients undergoing right mandibular third molar surgery will receive standard postoperative medication, including dexketoprofen 25 mg, amoxicillin 875 mg + clavulanic acid 125 mg, and a 0.12% chlorhexidine + 0.15% benzydamine mouthwash. Demographic data will be recorded preoperatively. All operations will be performed under sterile conditions with inferior alveolar nerve block and buccal infiltration using 4% articaine with 1:100,000 epinephrine. Surgical time will be measured from incision to final suture. Osteotomy and, when required, tooth sectioning will be performed with a surgical handpiece and saline irrigation. After extraction, sockets will be smoothed and closed with 3-0 silk sutures. Patients will be evaluated on postoperative days 1, 2, 3, and 7 for pain, edema, and trismus. In addition, the control group will receive a dietary supplement containing trypsin, chymotrypsin, and serratiopeptidase (Tripser Forte N30, Incir Pharma, Türkiye), with identical follow-up.",[13,14,15,16],[22,28,32,36],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"PROCEDURE","Pain Assessment","Pain will be assessed using a VAS on the 1st, 2nd, 3rd, and 7th postoperative days. For this purpose, the patient will be shown a 100-mm line with \"0\" at the left end and \"100\" at the right end. They will be instructed to mark the point on this line where their pain corresponds. The distance from the marked point to \"0\" will be measured with a ruler, and the resulting value will be recorded in mm to obtain the VAS score. Changes in these measurements will be recorded.",[18,9],null,{"type":23,"name":29,"description":30,"armGroupLabels":31,"otherNames":27},"Number of Analgesics Needed","In addition, the number of analgesics required by the patients up to the 7th postoperative day will be recorded.",[18,9],{"type":23,"name":33,"description":34,"armGroupLabels":35,"otherNames":27},"Edema Assessment","To assess edema, the tragus, lateral cauntus, corner of the mouth, and soft tissue pogonion points on the patient's face were marked preoperatively. Preoperatively, on the first, second, third, and seventh postoperative day, measurements will be taken and recorded between the Gonion-corner of the mouth, the Tragus-corner of the mouth, and the Gonion-lateral cauntus points.",[18,9],{"type":23,"name":37,"description":38,"armGroupLabels":39,"otherNames":27},"Trismus Assessment","To assess trismus, the distance between the incisal edges of the upper and lower incisors will be measured and recorded with the mouth maximally open, preoperatively, and on the first, second, third, and seventh postoperative day.",[18,9],[41],{"name":42,"role":43,"phone":44,"phoneExt":27,"email":45},"Özgün YILDIRIM, Doctor, Assistant Professor","CONTACT","+905366687527","ozgunyldrm89@gmail.com",[47],{"facility":48,"status":27,"city":49,"state":27,"zip":27,"country":50,"countryCode":27,"cosmosGeoPoint":51,"geoPoint":56,"contacts":27},"Health Sciences University","Ankara","Turkey (Türkiye)",{"type":52,"coordinates":53},"Point",[54,55],32.85427,39.91987,{"lat":55,"lon":54},{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"PRINCIPAL_INVESTIGATOR","Özgün Yıldırım","Doctor, Assistant Professor","100613636","the-effect-of-supplementary-foods-containing-trypsin-chymotrypsin-and-serratia-peptidase-on-healing-after-impacted-wisdom-tooth-surgery-100613636",false,"NCT07269171","The Effect of Supplementary Foods Containing Trypsin, Chymotrypsin and Serratia Peptidase on Healing After Impacted Wisdom Tooth Surgery","Evaluation of the Effects of Dietary Supplements Containing Trypsin, Chymotrypsin and Serratia Peptidase on Postoperative Edema, Pain and Trismus After Mandibular Impacted Third Molar Extraction.","Trypsin","Inclusion Criteria:\n\n* Having a mandibular third molar with a unilateral or bilateral Class 2, Position A or B impaction according to the Pell and Gregory classification\n* Being systemically healthy (ASA Class I)\n* Aged between 18 and 45 years (young adult age group)\n* Willingness to participate in the study\n\nExclusion Criteria:\n\n* Age outside the specified range\n* Pregnancy\n* Currently breastfeeding\n* Presence of infection in the third molar region (e.g., acute pericoronitis)\n* Presence of cystic or tumoral lesions associated with the impacted third molar\n* History of allergic reactions\n* Presence of any systemic disease\n* Unwillingness to participate in the study\n* Poor oral hygiene that may negatively affect healing\n* Smoking or alcohol addiction",true,"ALL","18 Years","45 Years",{"count":74,"type":75},15,"ESTIMATED","INTERVENTIONAL",[78],"NA","Introduction: The aim of this study was to determine the effects of a dietary supplement containing trypsin, chymotrypsin, and serratia peptidase (Tripser Forte N30, Incir Pharma, Turkey) on postoperative healing and to determine the differences between the groups. The aim was to identify differences between the groups regarding postoperative pain, edema, and trismus levels.\n\nMaterial and Method: Demographic data before surgery will be recorded on the patient follow-up form (Appendix 1). All surgical procedures will be performed under sterile conditions following the administration of local anesthesia (80 mg articaine hydrochloride and 0.02 mg epinephrine, Maxicaine Fort ampoule, Vem Pharmaceuticals, Istanbul, Turkey) with inferior alveolar block anesthesia and buccal mucosa anesthesia. Procedure monitoring will begin after the incision is made and will conclude with suturing. Osteotomy (bone removal) and, if necessary, root dissection will be performed using a surgical handpiece, accompanied by irrigation with sterile saline solution. Following tooth extraction, the socket will be examined, and any sharp bony prominences will be removed. The area will be closed primarily using non-resorbable silk suture material (3\u002F0 surgical silk suture, Doğsan, Turkey). A sterile tampon will be applied to the procedure area, and the patient will be instructed to bite on the tampon for 20 minutes before removing it and replacing it with another material. As a standard postoperative approach, all patients in group 1 received antibiotics (875 mg Amoxicillin+125 mg clavulonic acid, Augmentin-BID film coated tablets, GlaxoSmithKline, Istanbul, Turkey), analgesics (25 mg dexketoprofen, Arveles tb, UFSA Pharmaceutical Industry and Trade Inc. Davutpasa Cad. No.12 (34473) Topkapi\u002FIstanbul) and mouthwash (100 ml solution containing 120 mg (%0.12) chlorhexidine gluconate and 150 mg (%0.15) benzydamine hydrochloride) for use after surgery. Drogsan Pharmaceutical Industry and Trade Inc. Oguzlar neighborhood, 1370.sokak 7\u002F3 Balgat 06520 Cankaya\u002FAnkara). Patients will be instructed to take antibiotics morning and evening for 5 days, use mouthwash for 7 days starting the day after the procedure, and use mouthwash only when deemed necessary. They will be asked to record the amount they use on the provided home assessment form (Appendix 2). Patients in Group 2 will be given a dietary supplement containing trypsin, chymotrypsin, and serratia peptidase (Tripser Forte N30, Incir Pharma, Turkey) in addition to the medications mentioned above. Patient follow-up procedures will be the same.\n\nAll patients will be evaluated on the 1st, 2nd, 3rd, and 7th postoperative days, and pain, edema, and trismus will be recorded.",[81],"Oral Health Care",[83,84,85,86],"nutritional supplements","oral and maxillofacial surgery","wisdom teeth","trypsin, chymotrypsin and serratia peptidase","NOT_YET_RECRUITING","2025-11-25",{"date":90,"type":91},"2025-12-08","ACTUAL",{"date":93,"type":75},"2025-12-01",{"date":95,"type":75},"2026-03-10",{"name":5,"class":6},1]