[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617478":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":35,"centralContacts":36,"locations":42,"responsibleParty":55,"collaborators":59,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":35,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":35,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":85,"overallStatus":44,"whyStopped":35,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"The University of Hong Kong","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"IDLPFC tDCS","EXPERIMENTAL","This intervention is a 20 minutes per session, two-week tDCS neuromodulation of IDLPFC region (anode: F3, cathode: FP2) designed to reduce depressive symptoms via enhancing positive emotion functions, thereby reducing anhedonia.",[13],"Device: Transcranial Direct Current Stimulation",{"label":15,"type":10,"description":16,"interventionNames":17},"rVLPFC tDCS","This intervention is a 20 minutes per session, two-week tDCS neuromodulation of rVLPFC region (anode: F6, cathode: FP1) designed to reduce depressive symptoms via regulating negative emotion functions, thereby reducing depressed mood.",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Sham tDCS","SHAM_COMPARATOR","This is a 20 minutes per session, two-week Sham comparator of IDLPFC\u002FrVLPFC region, participants will receive tDCS for 30 seconds at either IDLPFC\u002FrVLPFC at the beginning of each session to stimulate real neuromodulation.",[23],"Device: Sham tDCS",[25,32],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DEVICE","Transcranial Direct Current Stimulation","TDCS is a non-invasive, safe, inexpensive, convenient and effective method to modulate brain and emotion functions. During tDCS, a mild electric current is passed between the anodal and cathodal electrodes on the scalp, which respectively excites and inhibits local and downstream neuronal activity, as well as modulating interregional connectivity strength. Compared to other neurostimulation methods such as Transcranial Magnetic Stimulation, tDCS side effects tend to be milder and transient, even if being administered for multiple sessions, making it suitable to be widely applied on clinical and subclinical populations.",[9,15],[31],"tDCS",{"type":26,"name":19,"description":33,"armGroupLabels":34,"otherNames":35},"The sham tDCS delivers actual stimulation for 30 seconds only, while providing similar psychological perceptions to participants as the real intervention. Thus, the sham tDCS serves as an active control condition to the tDCS interventions.",[19],null,[37],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},"Associate Professor, Principle Investigator","CONTACT","+852-3917-8927","rshao@hku.hk",[43],{"facility":5,"status":44,"city":45,"state":35,"zip":35,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Hong Kong","HK",{"type":48,"coordinates":49},"Point",[50,51],114.17469,22.27832,{"lat":51,"lon":50},[54],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},{"type":56,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"PRINCIPAL_INVESTIGATOR","Zhengxi Shao","Associate Professor",[60],{"name":61,"class":6},"Research Grants Council, Hong Kong","100617478","the-effect-of-transcranial-direct-current-stimulation-tdcs-in-improving-emotion-health-100617478",false,"NCT07319143","The Effect of Transcranial Direct Current Stimulation (tDCS) in Improving Emotion Health","Utilizing Transcranial Direct Current Stimulation (tDCS) to Alleviate Subthreshold Depression Via Distinct Positive and Negative Emotion Pathways","Inclusion Criteria:\n\n* Age 18-35 years\n* Fluency in Cantonese or Mandarin\n* Normal or corrected-to-normal vision and hearing\n* IQ \\> 75% Quantile in Raven's SPM\n* At least 9 years of formal education\n* Right-handedness\n\nExclusion Criteria:\n\n* Past or current major physical illness or psychiatric disorders\n* Use of psychotropic medication in the past 6 months\n* Pregnancy (for women)\n* Any condition that prevents safe tDCS use (e.g., brain injury, implants)\n* Previous participation in neuromodulation in the past 3 months",true,"ALL","18 Years","35 Years",{"count":74,"type":75},90,"ESTIMATED","INTERVENTIONAL",[78],"NA","The goal of this clinical trial is to investigate how transcranial direct current stimulation (tDCS) affects emotion functions in young adults aged 18-35 from the local community, including both male and female participants. The main question\\[s\\] it aims to answer are:\n\n* Does tDCS improve emotional functions, such as mood regulation and motivation, in individuals with subthreshold depression (StD)?\n* Can tDCS enhance emotional regulation compared to a sham stimulation (placebo)?\n\nResearchers will compare participants receiving tDCS on either the left dorsolateral prefrontal cortex (lDLPFC) or right ventrolateral prefrontal cortex (rVLPFC) with those receiving sham stimulation to see if tDCS has a stronger effect on emotional functions.\n\nParticipants will:\n\n* Complete online and in-person screening to assess depressive symptoms using the Chinese version of the Beck Depression Inventory II (C-BDI-II) and be selected based on their depressive symptoms (C-BDI-II score ≥ 13).\n* Be randomly assigned to one of three groups: lDLPFC tDCS, rVLPFC tDCS, or Sham control group (1:1:1 ratio).\n* Receive 10 sessions of tDCS or Sham tDCS over 2 weeks, with each session lasting 20 minutes.\n* Complete assessments at baseline, post-intervention, 1-month follow-up, and 3-month follow-up, with each assessment lasting 2-2.5 hours. This includes questionnaires and perform emotional and cognitive tasks.",[81,82,83,84],"Subthreshold Depression","Positive Emotions","Negative Emotions","Anhedonia",[27,81,86,87],"Emotion","Neuromodulation","2026-04-28",{"date":90,"type":91},"2026-05-04","ACTUAL",{"date":93,"type":91},"2026-01-08",{"date":95,"type":75},"2027-09-01",{"name":5,"class":6},1]