[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622784":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":31,"centralContacts":36,"locations":42,"responsibleParty":62,"collaborators":65,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":22,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":45,"whyStopped":22,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"University of Glasgow","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Sequential vitamin C intervention","EXPERIMENTAL","In this single-arm, sequential dietary intervention study, participants will follow their normal habitual diet for one week (run-in period) and then receive two different doses of vitamin C tablets over two consecutive 14-day periods: a moderate dose of 200 mg\u002Fday during the first period (2 weeks) and a high dose of 1000 mg\u002Fday during the second period (another 2 weeks). The study also includes one week post intervention follow up period (habitual diet) after the high vitamin C dose where participants return to their habitual diet without vitamin C supplementation",[13,14,15],"Dietary Supplement: Moderate Vitamin C dose (200 mg)","Dietary Supplement: High-dose vitamin C supplementation (1000 mg)","Other: Habitual diet (run in period)",[17,23,27],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"DIETARY_SUPPLEMENT","Moderate Vitamin C dose (200 mg)","200 mg of vitamin C provided as a chewable tablet, taken orally daily for two weeks",[9],null,{"type":18,"name":24,"description":25,"armGroupLabels":26,"otherNames":22},"High-dose vitamin C supplementation (1000 mg)","1000 mg of Vitamin C provided as a chewable tablet, taken orally daily for two weeks",[9],{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":22},"Habitual diet (run in period)","this is a run-in period where participants consume their habitual diet for one week",[9],[32],{"name":33,"affiliation":34,"role":35},"Athanasios Koutsos, PhD","Human Nutrition, School of Medicine, College of Medical, Veterinary, and Life Sciences, University of Glasgow","PRINCIPAL_INVESTIGATOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":22,"email":41},"Raihana Halim","CONTACT","07857 725347","2859495H@student.gla.ac.uk",[43],{"facility":44,"status":45,"city":46,"state":22,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"New Lister Building, Glasgow Royal Infirmary, 10-16 Alexandra Parade, G31 2ER","RECRUITING","Glasgow","G31 2ER","United Kingdom","UK",{"type":51,"coordinates":52},"Point",[53,54],-4.25763,55.86515,{"lat":54,"lon":53},[57,61],{"name":58,"role":39,"phone":22,"phoneExt":59,"email":60},"Athanasios Koutsos Lecturer in Human Nutrition, PhD","014195 60461","Athanasios.Koutsos@glasgow.ac.uk",{"name":33,"role":35,"phone":22,"phoneExt":22,"email":22},{"type":35,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"Athanasios Koutsos","Lecturer in Human Nutrition",[66],{"name":67,"class":68},"Professor Konstantinos Gerasimidis, University of Glasgow","UNKNOWN","100622784","the-effect-of-vitamin-c-supplementation-on-gut-microbiota-composition-and-function-in-healthy-adults-100622784",false,"NCT07388121","The Effect of Vitamin C Supplementation on Gut Microbiota Composition and Function in Healthy Adults","The Effect of Vitamin C Supplementation on Gut Microbiota Composition and Metabolic Activity in Healthy Adults","VitaGut","Inclusion Criteria:\n\n* Healthy individuals aged 18-65 years with a BMI between 18.5-35 Kg\u002Fm2\n* Self-reported good health with no chronic conditions requiring regular medical care\n* Willing to provide blood, urine, and stool samples at multiple time points\n\nExclusion Criteria:\n\n* Aged \\\u003C18 or \\>65 years\n* Smoking\n* Chronic illness requiring regular medication or GP visits\n* Current or recent medication affecting gut transit or digestion\n* Major gastrointestinal surgery\n* Pregnant or breastfeeding\n* Regular use of pre\u002Fprobiotics, vitamins, or minerals (unless willing to discontinue 2-4 weeks prior)\n* Antibiotics in past 3 months\n* Weight change \\>±2 kg in past month\n* Participation in other research likely to interfere with this study",true,"ALL","18 Years","65 Years",{"count":82,"type":83},23,"ESTIMATED","INTERVENTIONAL",[86],"NA","The aim of this dietary intervention study is to explore how vitamin C affects the bacteria that live in our gut. Vitamins are essential nutrients found in fruits and vegetables. Our bodies cannot make them on their own, but we need them to function correctly. Vitamins play various roles, including supporting the immune system and assisting with energy production. Some vitamins in our diet can reach the large intestine, where they may be used by gut bacteria to promote their growth. In this study, we aim to investigate how our gut bacteria interact with vitamin C and how this interaction affects their growth and activity.\n\nFor this study, participants will follow their habitual diet for one-week (run-in period), followed by two consecutive two-week supplementation periods in which they will first take a moderate dose (200 mg\u002Fday) and then a high-dose (1000 mg\u002Fday) of vitamin C. A final one-week period follow up period will involve a return to their habitual diet. Faecal, blood and urine samples will be collected at the start and end of each supplementation period to explore changes in gut microbiota composition, activity and markers of inflammation.",[89,90],"Short Chain Fatty Acids Concentration in Stools","Gut Microbiota Diversity and Composition",[92,93,94],"vitamin C","gut microbiota","SCFA","2026-01-30",{"date":97,"type":98},"2026-02-04","ACTUAL",{"date":100,"type":98},"2025-11-01",{"date":102,"type":83},"2026-07-01",{"name":5,"class":6},1]