[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100487006":3},{"organization":4,"armGroups":7,"interventions":36,"overallOfficials":50,"centralContacts":55,"locations":64,"responsibleParty":83,"collaborators":41,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":90,"acronym":41,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":93,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":41,"studyType":99,"phases":100,"briefSummary":102,"conditions":103,"keywords":107,"overallStatus":66,"whyStopped":41,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"Simon Fraser University","OTHER",[8,16,20,24,28,32],{"label":9,"type":10,"description":11,"interventionNames":12},"500mL carbonated water first, then 500mL of still water, then 50mL of still water","EXPERIMENTAL","Participants will undergo this test on three separate days. On each day participants will be asked to drink a glass of water: either a 50mL drink of still water (control condition), a 500mL drink of still (non-carbonated) water, or a 500mL drink of carbonated water. In this arm of the study, participants will receive 500mL carbonated water on the first test day, 500mL still water on the second test day, then 50mL still water on the third day.",[13,14,15],"Other: 500mL carbonated water","Other: 500mL still water","Other: 50mL still water",{"label":17,"type":10,"description":18,"interventionNames":19},"500mL still water first, then 500 mL carbonated water, then 50mL still water","Participants will undergo this test on three separate days. On each day participants will be asked to drink a glass of water: either a 50mL drink of still water (control condition), a 500mL drink of still (non-carbonated) water, or a 500mL drink of carbonated water. In this arm of the study, participants will receive 500mL still water on the first test day, 500mL carbonated water on the second test day, then 50mL still water on the third day.",[13,14,15],{"label":21,"type":10,"description":22,"interventionNames":23},"500mL carbonated water first, then 50mL of still water, then 500mL of still water","Participants will undergo this test on three separate days. On each day participants will be asked to drink a glass of water: either a 50mL drink of still water (control condition), a 500mL drink of still (non-carbonated) water, or a 500mL drink of carbonated water. In this arm of the study, participants will receive 500mL carbonated water on the first test day, 50mL still water on the second test day, then 500mL still water on the third day.",[13,14,15],{"label":25,"type":10,"description":26,"interventionNames":27},"500mL still water first, then 50mL still water, then 500 mL carbonated water","Participants will undergo this test on three separate days. On each day participants will be asked to drink a glass of water: either a 50mL drink of still water (control condition), a 500mL drink of still (non-carbonated) water, or a 500mL drink of carbonated water. In this arm of the study, participants will receive 500mL still water on the first test day, 50mL still water on the second test day, then 500mL carbonated water on the third day.",[13,14,15],{"label":29,"type":10,"description":30,"interventionNames":31},"50mL still water first, then 500mL still water, then 500 mL carbonated water","Participants will undergo this test on three separate days. On each day participants will be asked to drink a glass of water: either a 50mL drink of still water (control condition), a 500mL drink of still (non-carbonated) water, or a 500mL drink of carbonated water. In this arm of the study, participants will receive 50mL still water on the first test day, 500mL carbonated water on the second test day, then 500mL carbonated water on the third day.",[13,14,15],{"label":33,"type":10,"description":34,"interventionNames":35},"50mL still water first, then 500mL carbonated water, then 500 mL still water","Participants will undergo this test on three separate days. On each day participants will be asked to drink a glass of water: either a 50mL drink of still water (control condition), a 500mL drink of still (non-carbonated) water, or a 500mL drink of carbonated water. In this arm of the study, participants will receive 50mL still water on the first test day, 500mL still water on the second test day, then 500mL still water on the third day.",[13,14,15],[37,42,46],{"type":6,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"500mL carbonated water","Drink 500mL carbonated water immediately prior to head-up tilt test",[9,21,17,25,33,29],null,{"type":6,"name":43,"description":44,"armGroupLabels":45,"otherNames":41},"500mL still water","Drink 500mL still water immediately prior to head-up tilt test",[9,21,17,25,33,29],{"type":6,"name":47,"description":48,"armGroupLabels":49,"otherNames":41},"50mL still water","Drink 50mL still water immediately prior to head-up tilt test",[9,21,17,25,33,29],[51],{"name":52,"affiliation":53,"role":54},"Victoria E Claydon, PhD","Professor, Biomedical Physiology and Kinesiology","PRINCIPAL_INVESTIGATOR",[56,60],{"name":52,"role":57,"phone":58,"phoneExt":41,"email":59},"CONTACT","7787828513","victoria_claydon@sfu.ca",{"name":61,"role":57,"phone":62,"phoneExt":41,"email":63},"Vera-Ellen M Lucci, PhD","7787828560","vlucci@sfu.ca",[65],{"facility":5,"status":66,"city":67,"state":68,"zip":69,"country":70,"countryCode":71,"cosmosGeoPoint":72,"geoPoint":77,"contacts":78},"RECRUITING","Burnaby","British Columbia","V5A 1S6","Canada","CA",{"type":73,"coordinates":74},"Point",[75,76],-122.95263,49.26636,{"lat":76,"lon":75},[79,80,81],{"name":61,"role":57,"phone":62,"phoneExt":41,"email":63},{"name":52,"role":54,"phone":41,"phoneExt":41,"email":41},{"name":61,"role":82,"phone":41,"phoneExt":41,"email":41},"SUB_INVESTIGATOR",{"type":54,"investigatorFullName":84,"investigatorTitle":85,"investigatorAffiliation":5,"oldNameTitle":41,"oldOrganization":41},"Dr. Victoria Claydon","Professor","100487006","the-effect-of-water-carbonation-on-orthostatic-tolerance-100487006",false,"NCT05621460","The Effect of Water Carbonation on Orthostatic Tolerance","Inclusion Criteria:\n\n* healthy, English-speaking\n\nExclusion Criteria:\n\n* pregnancy or suspected pregnancy, history of cardiovascular disease, history of neurological disease, history of recurrent fainting (≥ 2 episodes of fainting with loss of consciousness in the prior 6 months)",true,"ALL","19 Years","50 Years",{"count":97,"type":98},25,"ESTIMATED","INTERVENTIONAL",[101],"NA","The primary purpose of this investigation is to determine whether water carbonation can improve orthostatic tolerance in healthy control volunteers. Orthostatic tolerance refers to the ability to maintain an adequate blood pressure when standing. In some individuals blood pressure can fall when standing, predisposing to dizzy spells or fainting episodes. Drinking water can boost blood pressure and making fainting episodes less likely. However, it is not clear whether the carbonation of the water has any further impact on the blood pressure response. This is important because it may be that carbonated water expands the stomach (gastric distension), provoking an increase in sympathetic activity. The increase in sympathetic nervous system activity boosts blood pressure. Resolving this question would have important implications for patients with syncope. This study will test whether carbonated water will have any further impact on blood pressure than the already known effect of non-carbonated water.",[104,105,106],"Orthostatic Hypotension","Syncope","Vasovagal Syncope",[108,109,110],"Tilt table","Osmopressor reflex","Gastropressor reflex","2026-04-22",{"date":113,"type":114},"2026-04-23","ACTUAL",{"date":116,"type":114},"2023-09-01",{"date":118,"type":98},"2027-04",{"name":5,"class":6},1]