[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615621":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":26,"responsibleParty":41,"collaborators":10,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":10,"eligibilityCriteria":49,"healthyVolunteers":45,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":56,"studyType":57,"phases":10,"briefSummary":58,"conditions":59,"keywords":10,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},{"fullName":5,"class":6},"Peking University Shenzhen Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"ciprofol group",null,"Anesthesia induction was achieved through target-controlled infusion of ciprofol.",[13],"Drug: Ciprofol",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DRUG","Ciprofol","Beginning with an initial target plasma concentration of ciprofol at 1.2 μg\u002FmL. Assessments of the Modified Observer's Assessment of Alertness\u002FSedation (MOAA\u002FS) scale and Bispectral Index (BIS) values are performed every minute until the patient achieves a complete anesthetic state (defined as an MOAA\u002FS score of 0).",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Tao Luo","CONTACT","+86 135 1082 0779","496855048@qq.com",[27],{"facility":5,"status":28,"city":29,"state":30,"zip":10,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"RECRUITING","Shenzhen","Guangdong","China","CN",{"type":34,"coordinates":35},"Point",[36,37],114.0683,22.54554,{"lat":37,"lon":36},[40],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},{"type":42,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100615621","the-effective-blood-concentration-of-ciprofol-100615621",false,"NCT07294989","The Effective Blood Concentration of Ciprofol","Median Effective Concentration of Ciprofol and Its Correlation With Bispectral Index: A Prospective Observational Study","Inclusion Criteria:\n\n* Patients aged 18-65 years\n* Scheduled for elective thyroidectomy\n* ASA physical status classification I-II\n* Willing to participate and providing written informed consent\n\nExclusion Criteria:\n\n* Recent use of sedatives or opioid analgesics\n* Severe hepatic or renal dysfunction defined as:Child-Pugh class C (score ≥10), Creatinine clearance \\\u003C35 mL\u002Fmin ,Requiring preoperative dialysis\n* Significant cardiovascular comorbidities\n* Body mass index ≥35 kg\u002Fm² or \\\u003C18.5 kg\u002Fm²\n* Known hypersensitivity or adverse reactions to propofol\u002Fciprofol\n* Neuropsychiatric disorders including:Alzheimer's disease,History of cerebrovascular events,Traumatic brain injury,Space-occupying brain lesions,Other significant neurological deficits","ALL","18 Years","65 Years",{"count":54,"type":55},101,"ESTIMATED","1 Day","OBSERVATIONAL","1. Eligible patients were selected and enrolled in the study.\n2. General anesthesia was induced using ciprofol in all participants, with standardized evaluation of consciousness levels during induction.\n3. The patients' pain and cognition are followed up after surgery.",[60],"Thyroid Disease","2026-01-05",{"date":63,"type":64},"2026-01-06","ACTUAL",{"date":66,"type":64},"2025-07-01",{"date":68,"type":55},"2026-06-30",{"name":5,"class":6},1]