[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612841":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":26,"locations":25,"responsibleParty":32,"collaborators":25,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":42,"eligibilityCriteria":43,"healthyVolunteers":38,"sex":44,"minAge":45,"maxAge":46,"enrollmentInfo":47,"targetDuration":25,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":25,"overallStatus":58,"whyStopped":25,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":25},{"fullName":5,"class":6},"Guangdong Provincial People's Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Bio-CPR experimental group","EXPERIMENTAL","Bio-CPR ventilation mode",[13],"Procedure: CPR",{"label":15,"type":16,"description":17,"interventionNames":18},"Traditional compression\u002Fventilation mode group","ACTIVE_COMPARATOR","Traditional compression\u002Fventilation mode",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","CPR","ACLS\u002FCPR (Bio-CPR Group vs. Traditional Resuscitation Group)\n\nThis intervention targets adult patients with in-hospital or out-of-hospital cardiac arrest (CA) who require advanced resuscitation. All patients receive immediate basic life support (BLS) upon medical contact, followed by standardized advanced cardiac life support (ACLS) with uniform use of the integrated \"CPR Machine E8 - Ventilator T7\" system (distinguishing it from manual CPR or other device-based protocols). Randomization determines two subgroups with distinct ventilation and compression-coordination settings, as detailed below:\n\n1\\. Core Uniform Foundation (Applicable to Both Groups) Chest Compression Mode: Continuous compression mode is activated on the CPR Machine E8, eliminating variability from manual compression rate\u002Fdepth and ensuring consistent compression quality.\n\nAirway \\& Vascular Access: Advanced airway (e.g., endotracheal intubation) is established as soon as possible post-BLS initiation; peripheral or central",[9,15],null,[27],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},"Feier Song Song, MD","CONTACT","86-020-83827812","feiersong@126.com",{"type":33,"investigatorFullName":34,"investigatorTitle":35,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","lixin","Vice President","100612841","the-effectiveness-of-continuous-compression-synchronous-ventilation-bio-cpr-100612841",false,"NCT07258823","the Effectiveness of Continuous Compression-synchronous Ventilation (Bio-CPR)","Study on the Effectiveness of Continuous Compression-synchronous Ventilation (Bio-CPR) in the ACLS Stage of Cardiopulmonary Resuscitation (ACLS) Based on the Bionic Concept to Explore the Best Mechanical Ventilation Strategy","Bio-CPR","Inclusion Criteria:\n\n1. 18-65 years old; 2. Cardiac arrest with witnesses; 3. Onset - compression start time\\\u003C5 minutes; 4. Initial ventricular fibrillation rhythm; 5. Endotracheal intubation and use of a mechanical chest CPR device; Patients with OHCA who meet the above conditions\n\nExclusion Criteria:\n\n* 1\\. OHCA patients who are not suitable for mechanical compression ventilation; 2. The participant or his\u002Fher legally authorized representative (LAR) is unable or unwilling to provide written informed consent.","ALL","18 Years","75 Years",{"count":48,"type":49},408,"ESTIMATED","INTERVENTIONAL",[52],"NA","Bio-CPR is an innovative new mechanical resuscitation model proposed by our research group. A multi-center RCT study was established to comprehensively evaluate the efficacy of this model and the current standard CPR protocol, verify its safety and efficacy, and provide high-quality clinical evidence support.",[55,56,22,57],"Out-of-hospital Cardiac Arrest (OHCA)","Cardiac Arrest (CA)","ACLS","NOT_YET_RECRUITING","2025-11-21",{"date":61,"type":62},"2025-12-02","ACTUAL",{"date":64,"type":49},"2026-02-01",{"date":66,"type":49},"2027-08-31",{"name":5,"class":6}]