[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100595395":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":35,"centralContacts":43,"locations":24,"responsibleParty":48,"collaborators":24,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":24,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":75,"whyStopped":24,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":24},{"fullName":5,"class":6},"TC Erciyes University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Bovine-derived graft\u002Fxenograft enriched with hyaluronic acid study group","EXPERIMENTAL","Study group - Patients whose alveolar bone is pre-evaluated using cone-beam computed tomography (CBCT) will receive a bovine-derived graft\u002Fxenograft enriched with hyaluronic acid in the extraction socket after tooth removal. Patients will be evaluated clinically, radiologically, and histologically at 4 months. Dental implants will be placed in the edentulous areas where the graft was applied. Bone samples will be collected during the preparation of the implant sockets and analyzed histologically. A third CBCT scan will be performed 6 months after implant placement to radiographically assess new bone formation and implant success.",[13],"Combination Product: a bovine-derived graft\u002Fxenograft enriched with hyaluronic acid",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard bovine-derived graft\u002Fxenograft comparison group","ACTIVE_COMPARATOR","Comparison group - Patients whose alveolar bone is pre-evaluated using CBCT will receive a standard bovine-derived graft\u002Fxenograft in the extraction socket after tooth removal. Patients will be evaluated clinically, radiologically, and histologically at 4 months. Dental implants will be placed in the grafted areas. Bone samples will be collected during implant socket preparation and analyzed histologically. A third CBCT scan will be performed 6 months after implant placement to assess new bone formation and implant success.",[19],"Combination Product: a standart bovine-derived graft\u002Fxenograft",{"label":21,"type":22,"description":23,"interventionNames":24},"Control group without graft material","NO_INTERVENTION","Control group - Patients whose alveolar bone is pre-evaluated using CBCT will undergo tooth extraction without graft material application, allowing for natural healing of the socket. Patients will be evaluated clinically, radiologically, and histologically at 4 months. Dental implants will be placed in the edentulous areas. Bone samples will be collected during the preparation of the implant sockets and analyzed histologically. A third CBCT scan will be performed 6 months after implant placement to assess new bone formation and implant success.",null,[26,31],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":24},"COMBINATION_PRODUCT","a bovine-derived graft\u002Fxenograft enriched with hyaluronic acid","In study group a bovine-derived graft\u002Fxenograft enriched with hyaluronic acid will be placed in the extraction socket after tooth removal.",[9],{"type":27,"name":32,"description":33,"armGroupLabels":34,"otherNames":24},"a standart bovine-derived graft\u002Fxenograft","In comparison group a standard bovine-derived graft\u002Fxenograft will be placed in the extraction socket after tooth removal.",[15],[36,40],{"name":37,"affiliation":38,"role":39},"Duygu Kılıç, PhD","Erciyes University Faculty of Dentistry Department of Periodontology","STUDY_DIRECTOR",{"name":41,"affiliation":38,"role":42},"Fidan Gulıyeva, Research Assistant","PRINCIPAL_INVESTIGATOR",[44],{"name":37,"role":45,"phone":46,"phoneExt":24,"email":47},"CONTACT","+903522076600","duygukilic4838@gmail.com",{"type":42,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Duygu Kilic","PhD","100595395","the-effectiveness-of-hyaluronic-acid-in-bone-regeneration-100595395",false,"NCT07031895","The Effectiveness of Hyaluronic Acid in Bone Regeneration","Evaluation of the Efficacy of Xenograft Containing Hyaluronic Acid in Socket Preservation Procedure Radiologically and Histologically: A Prospective Randomized Controlled Clinical Study","socket healing","Inclusion Criteria:\n\n* Socket type: Sockets with less than 50% bone resorption in the buccal and palatal\u002Flingual walls according to the Kim JJ classification (Type I-IVa)\n\nAge range: 18-65 years\n\nAbsence of active periodontal disease\n\nNo systemic diseases\n\nPatients who will attend regular follow-up visits\n\nExclusion Criteria:\n\n* Smoking\n\nUncontrolled systemic disease\n\nPresence of infection in the area\n\nUse of medications affecting bone metabolism\n\nPregnancy or lactation",true,"ALL","18 Years","65 Years",{"count":64,"type":65},60,"ESTIMATED","INTERVENTIONAL",[68],"NA","Bone loss due to resorption is commonly observed in the alveolar socket following tooth extraction. This situation makes it difficult to preserve sufficient bone volume that would allow for ideal implant placement in cases requiring dental implants. Alveolar ridge preservation is a procedure aimed at minimizing bone resorption and preserving the volume and morphology of the alveolar ridge after tooth extraction.\n\nThe aim of this study is to evaluate the clinical effectiveness of socket preservation using a xenograft enriched with hyaluronic acid in patients with defective extraction sockets.\n\nThis study is designed as a randomized, controlled clinical trial including three parallel groups:\n\nStudy group - Patients whose alveolar bone was evaluated using cone-beam computed tomography (CBCT) will undergo tooth extraction, followed by the application of a bovine-derived graft\u002Fxenograft enriched with hyaluronic acid into the socket. Patients will be evaluated clinically, radiologically, and histologically at the 4th month. Dental implants will be placed in the edentulous areas where the graft was applied. Bone samples will be taken during the preparation of the implant sockets, and the bone tissue will be examined histologically. A third CBCT scan will be taken 6 months after implant placement to assess new bone formation and implant success radiographically.\n\nComparison group - Patients whose alveolar bone was evaluated using CBCT will undergo tooth extraction, followed by the application of a standard bovine-derived graft\u002Fxenograft into the socket. Patients will be evaluated clinically, radiologically, and histologically at the 4th month. Dental implants will be placed in the edentulous areas where the graft was applied. Bone samples will be taken during the preparation of the implant sockets, and the bone tissue will be examined histologically. A third CBCT scan will be taken 6 months after implant placement to assess new bone formation and implant success radiographically.\n\nControl group - Patients whose alveolar bone was evaluated using CBCT will undergo tooth extraction, and the socket will be left to heal naturally without the application of any graft material. Patients will be evaluated clinically, radiologically, and histologically at the 4th month. Dental implants will be placed in the edentulous areas. Bone samples will be taken during the preparation of the implant sockets, and the bone tissue will be examined histologically. A third CBCT scan will be taken 6 months after implant placement to assess new bone formation and implant success radiographically.",[71],"Socket Preservation",[71,73,74],"hyaluronic acid","bone formation","NOT_YET_RECRUITING","2025-08-15",{"date":78,"type":79},"2025-08-20","ACTUAL",{"date":81,"type":65},"2025-09-02",{"date":83,"type":65},"2026-09-01",{"name":5,"class":6}]