[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622687":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":53,"collaborators":26,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":58,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":26,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":81,"whyStopped":26,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Peking University Third Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Hormone Nasal Drops Combined with Olfactory Training Group","EXPERIMENTAL","Olfactory Cleft Steroid Nasal Drops: Patients will be instructed to assume the Mygind position. Five drops of budesonide suspension (2ml:1mg) will be instilled into each nostril to facilitate delivery to the olfactory cleft. This position will be maintained for 5 minutes, after which patients should expectorate any residual medication. The treatment regimen will follow a tapered schedule: twice daily during the first treatment month, reduced to once daily in the second month, and further reduced to every other day in the third month.\n\nOlfactory Training: Participants will perform olfactory training using a modified training device programmed with four distinct odorants (rose, peppermint, tea tree, and clove). Each odorant will be sniffed for 10 seconds per nostril, with 10-second intervals between odorants. Each training session lasts 5 minutes and is conducted twice daily, before breakfast and at bedtime, for a duration of 3 months.",[13],"Combination Product: Steroid nasal drops combined with olfactory training",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Nasal Drops Combined with Olfactory Training Group","PLACEBO_COMPARATOR","The placebo group will receive normal saline nasal drops, with all other procedures identical to those in the intervention group.",[19],"Combination Product: Placebo nasal drops combined with olfactory training",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"COMBINATION_PRODUCT","Steroid nasal drops combined with olfactory training","The intervention consists of two components: steroid nasal drops and modified olfactory training.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo nasal drops combined with olfactory training","The intervention consists of two components: normal saline nasal drops and modified olfactory training.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Dawei Wu, MD, PhD","CONTACT","13522503401","davidwuorl@163.com",[38],{"facility":39,"status":26,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Dawei Wu","Beijing","Beijing Municipality","100191","China","CN",{"type":46,"coordinates":47},"Point",[48,49],116.39723,39.9075,{"lat":49,"lon":48},[52],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"type":54,"investigatorFullName":39,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Associate Researcher","100622687","the-effectiveness-of-steroid-nasal-drops-in-the-olfactory-cleft-combined-with-olfactory-training-for-patients-with-piod-100622687",false,"NCT07386860","The Effectiveness of Steroid Nasal Drops in the Olfactory Cleft Combined With Olfactory Training for Patients With PIOD","Randomized Controlled Study on the Effectiveness of Steroid Nasal Drops in the Olfactory Cleft Combined With Olfactory Training for Patients With Post-infectious Olfactory Dysfunction","PIOD","Inclusion Criteria:\n\n1. Prospective enrollment of otolaryngology clinic patients aged 18-65 years with olfactory dysfunction. Diagnosis of post-infectious olfactory dysfunction (PIOD) will be based on the PPOD 2023 criteria. Participants must demonstrate olfactory impairment via Sniffin' Sticks testing, with TDI scores (sum of Threshold, Discrimination, and Identification) meeting: (1) Hyposmia: 16 \\\u003C TDI \\\u003C 30.75; (2) Anosmia: TDI ≤ 15.\n2. Willingness to participate and signed informed consent.\n\nExclusion Criteria:\n\n1. Use of systemic corticosteroids within 4 weeks or intranasal steroids within 2 weeks prior to enrollment.\n2. Severe nasal septum deviation, nasal tumors, acute upper respiratory infections, or uncontrolled allergic rhinitis.\n3. History of functional endoscopic sinus surgery or other nasal procedures within 12 months.\n4. Severe cardiovascular disease, hepatic\u002Frenal insufficiency, uncontrolled diabetes, or immune system disorders.\n5. Current or planned pregnancy.\n6. Investigator-determined inability to comply with study requirements (e.g., memory\u002Fbehavioral disorders, depression, heavy alcohol use, prior non-compliance).","ALL","18 Years","65 Years",{"count":68,"type":69},100,"ESTIMATED","INTERVENTIONAL",[72],"NA","This study aims to evaluate the effectiveness of hormone nasal drops in the olfactory cleft combined with olfactory training for treating postinfectious olfactory dysfunction (PIOD). The main questions this clinical trial seeks to answer are:\n\nCan the combination of hormone nasal drops and olfactory training improve smell function better than olfactory training alone in PIOD patients? How does this combined treatment work?",[75],"Smell Dysfunction",[77,78,79,80],"post-infectious olfactory dysfunction","olfactory training","steroid drops","combined therapy","NOT_YET_RECRUITING","2026-02-02",{"date":84,"type":85},"2026-02-04","ACTUAL",{"date":87,"type":69},"2026-03-01",{"date":89,"type":69},"2028-12-31",{"name":5,"class":6},1]