[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623387":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":35,"locations":42,"responsibleParty":54,"collaborators":25,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":25,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":25,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":25,"overallStatus":44,"whyStopped":25,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Maastricht University Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Ketogenic nutritional supplement","EXPERIMENTAL","Daily ketogenic nutritional supplement for 4 weeks",[13],"Dietary Supplement: ketogenic nutritional Supplement",{"label":15,"type":16,"description":17,"interventionNames":18},"non-ketogenic, isocaloric control","PLACEBO_COMPARATOR","Daily control for 4 weeks",[19],"Dietary Supplement: non-ketogenic, isocaloric control",[21,26],{"type":22,"name":23,"description":11,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","ketogenic nutritional Supplement",[9],null,{"type":22,"name":15,"description":17,"armGroupLabels":27,"otherNames":25},[15],[29,33],{"name":30,"affiliation":31,"role":32},"Joris Hoeks, Dr.","Maastricht University","PRINCIPAL_INVESTIGATOR",{"name":34,"affiliation":31,"role":32},"Peter Joris, Dr.",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Merel Timmermans, MSc","CONTACT","0031 88 3887793","merel.timmermans@maastrichtuniversity.nl",{"name":30,"role":38,"phone":25,"phoneExt":25,"email":25},[43],{"facility":31,"status":44,"city":45,"state":25,"zip":25,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":25},"RECRUITING","Maastricht","Netherlands","NL",{"type":49,"coordinates":50},"Point",[51,52],5.68889,50.84833,{"lat":52,"lon":51},{"type":55,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100623387","the-effects-of-a-4-week-supplementation-with-a-ketogenic-nutrient-mix-on-24-hour-substrate-metabolism-and-muscle-health-100623387",false,"NCT07395973","The Effects of a 4-week Supplementation With a Ketogenic Nutrient Mix on 24-hour Substrate Metabolism and Muscle Health","Inclusion Criteria:\n\n* Aged 60-80 years\n* Body mass index (BMI) 25-35 kg\u002Fm2\n* Sedentary lifestyle (not more than 2 hours of structured physical activity per week in the past 3 months)\n* Stable dietary habits (no weight loss or gain \\> 5 kg in the past 3 months)\n* Healthy (as determined by dependent physician based on medical questionnaire)\n* Regular sleeping habits (7-9h of daily sleep)\n\nExclusion Criteria:\n\n* Type 2 diabetes\n* Participants with active congestive heart failure and\u002For severe renal and or liver insufficiency\n* Uncontrolled hypertension\n* Alcohol consumption of \\>3 servings per day for men and \\>2 servings per day for women\n* Unstable body weight (weight gain or loss \\> 5 kg in the last 3 months) or intention to lose weight\n* Participants who are on an intermittent fasting diet\n* Previous enrolment in a clinical study with an investigational product during the last 3 months or as judged by the investigator which would possibly hamper our study results\n* Significant food allergies\u002Fintolerance (seriously hampering study meals or study product)\n* Participants who do not want to be informed about unexpected medical findings\n* Blood donation during or within 2 months prior to the study\n* Disturbances in circadian rhythm determined with the follow criteria:\n* Extreme early bird or extreme night person (score ≤30 or ≥70 on MEQ-SA questionnaire)\n* Heavily varying sleep-wake rhythm\n* Night shift work during last 3 months\n* Travel across \\> 1 time zone in the last 3 months\n* High daily caffeine intake \\> 400mg (more than 4 cups of coffee or energy drinks)",true,"ALL","60 Years","80 Years",{"count":67,"type":68},14,"ESTIMATED","INTERVENTIONAL",[71],"NA","This study will investigate the effect of providing a daily ketogenic nutritional supplement in the evening for a prolonged time (4 weeks) to induce a mild ketogenic state during the night in healthy elderly (60-80 years), overweight\u002Fobese (BMI: 25-35 kg\u002Fm2) individuals with low physical activity, on 24h rhythmicity in energy metabolism as compared to a non-ketogenic, isocaloric control.",[74],"Overweight and Obesity","2026-02-03",{"date":77,"type":78},"2026-02-09","ACTUAL",{"date":80,"type":78},"2025-11-25",{"date":82,"type":68},"2027-10-31",{"name":5,"class":6},1]