[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100521798":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":60,"collaborators":26,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":26,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":26,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":26,"overallStatus":43,"whyStopped":26,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Integrative Skin Science and Research","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Almonds","EXPERIMENTAL","Consumption of almonds 5 times per week",[13],"Other: Food: whole almonds",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Snack","PLACEBO_COMPARATOR","Consumption of protein and calorie matched non-nut-based food 5 times per week",[19],"Other: Food: non-nut snack",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"OTHER","Food: whole almonds","60 grams or (\\~2 oz) will be consumed 5 times per week.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Food: non-nut snack","Protein and calorie matched non-nut-based food will be consumed 5 times per week by mouth",[15],[32],{"name":33,"affiliation":5,"role":34},"Raja Sivamani, MD MS AP","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Sarah Adnan","CONTACT","9168074299","sarah@integrativeskinresearch.com",[42],{"facility":5,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Sacramento","California","95819","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-121.4944,38.58157,{"lat":53,"lon":52},[56],{"name":57,"role":38,"phone":58,"phoneExt":26,"email":59},"Nasima Afzal","916-750-2463","nasima@integrativeskinresearch.com",{"type":61,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100521798","the-effects-of-almond-on-facial-skin-collagen-and-wrinkles-100521798",false,"NCT06074276","The Effects of Almond on Facial Skin Collagen and Wrinkles","Prospective Randomized Controlled Trial on the Effects of Almond on Facial Skin Collagen and Wrinkles","Inclusion Criteria:\n\n* Subjects 35 to 70 years of age of all skin types\n* 50% of the subjects will be postmenopausal women determined as \\>1-year loss of menstrual period\n* 50% of the subjects will be premenopausal women\n* BMI 18.5 - 35 kg\u002Fm2\n* Individuals with a habitual diet that has been maintained for at least 6 months and to be maintained for the duration of the study\n* Individuals must maintain their usual skincare products, defined as products that has been used for at least 1 month, for the duration of the study\n\nExclusion Criteria:\n\n* Those with a nut allergy\n* Those who are unwilling to discontinue oral collagen supplementation 1 month prior to the start of the study\n* Individuals who are unwilling to discontinue vitamin E or nut containing supplements 2 weeks prior to and during the intervention.\n* Individuals who are pregnant or breastfeeding\n* Change in skincare products during the study\n* Had a medical or cosmetic procedure such as laser resurfacing or plastic surgery to the face within the last 6 months (include botulinum toxin, dermal fillers, collagen, or other similar cosmetic procedure)\n* Has an autoimmune photosensitive condition or known genetic condition with a deficiency in collagen production (such as Ehler-Danlos)\n* Those with a skin disease on their face that would affect the assessment of their skin based on the assessment of the investigator.\n* Current tobacco smoker or a tobacco smoking history of greater than 10 pack-years",true,"FEMALE","35 Years","70 Years",{"count":74,"type":75},60,"ESTIMATED","INTERVENTIONAL",[78],"NA","Investigate the effects of almond consumption on collagen production, elastin levels, wrinkles, and pigmentation among premenopausal women and postmenopausal women belonging to all Fitzpatrick skin types.",[81,82,83,84],"Collagen Degeneration","Wrinkle","Pigmentation","Elastic Skin","2024-06-15",{"date":87,"type":88},"2024-06-18","ACTUAL",{"date":90,"type":88},"2023-10-04",{"date":92,"type":75},"2024-12-31",{"name":5,"class":6},1]