[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100526714":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":10,"centralContacts":38,"locations":44,"responsibleParty":62,"collaborators":10,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":10,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":10,"enrollmentInfo":74,"targetDuration":10,"studyType":77,"phases":10,"briefSummary":78,"conditions":79,"keywords":10,"overallStatus":47,"whyStopped":10,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Beijing Tiantan Hospital","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Dex group",null,"Participants will be sedated and maintained by dexmedetomidine.",[13],"Drug: Dexmedetomidine",{"label":15,"type":10,"description":16,"interventionNames":17},"Propofol group","Participants will be sedated and maintained by propofol.",[18],"Drug: Propofol",{"label":20,"type":10,"description":21,"interventionNames":22},"Remimazolam group","Participants will be sedated and maintained by remimazolam.",[23],"Drug: Remimazolam Injection",[25,30,34],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"DRUG","Dexmedetomidine","Participants will be sedated and maintained by dexmedetomidine during the surgery.",[9],{"type":26,"name":31,"description":32,"armGroupLabels":33,"otherNames":10},"Propofol","Participants will be sedated and maintained by propofol during the surgery.",[15],{"type":26,"name":35,"description":36,"armGroupLabels":37,"otherNames":10},"Remimazolam Injection","Participants will be sedated and maintained by remimazolam during the surgery.",[20],[39],{"name":40,"role":41,"phone":42,"phoneExt":10,"email":43},"Yuming Peng, MD,Ph.D","CONTACT","8610-59976658","florapym766@163.com",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Beijing Tian Tan Hospital, Capital Medical University","RECRUITING","Beijing","Beijing Municipality","100070","China","CN",{"type":54,"coordinates":55},"Point",[56,57],116.39723,39.9075,{"lat":57,"lon":56},[60],{"name":61,"role":41,"phone":42,"phoneExt":10,"email":43},"Yuming Peng",{"type":63,"investigatorFullName":61,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Deputy chief of Department of Anesthesiology","100526714","the-effects-of-anesthetics-on-brain-network-connectivity-in-patients-with-supratentorial-glioma-100526714",false,"NCT06138340","The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma","The Alterations of Brain Network Connectivity Under Sedation and Anesthesia in Patients With Supratentorial Glioma","Inclusion Criteria:\n\n* Diagnosed as unilateral supratentorial glioma by MRI\n* Selective operation\n* Age over 18 years old\n* ASA I-II\n* Right handedness\n\nExclusion Criteria:\n\n* History of cerebrovascular disease, brain trauma, chemotherapy and radiotherapy, or psychotropic drugs\n* History of intracranial surgery\n* Drug and\u002For alcohol abuse\n* History of dementia or mental illness\n* Pregnant or lactating women\n* Contraindications for MRI\n* Severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block\n* Severe hepatic or renal dysfunction","ALL","18 Years",{"count":75,"type":76},120,"ESTIMATED","OBSERVATIONAL","Perioperative anesthesia can affect postoperative cognitive function. In our previous study, intraoperative dexmedetomidine (Dex) infusion reduced the incidence of delirium within the first 5 days after brain tumor. However, the mechanism is still unclear. With the development of neuroimaging, multimodal neuroimaging technology provide a new method to explore the underlying mechanism. Therefore, the purpose of this study is to analyze the alterations of brain network under sedation and anesthesia by different anesthetics in patients with supratentorial glioma and their association with cognition.",[80,81,27,31],"Brain Network Connectivity","Postoperative Delirium","2025-02-12",{"date":84,"type":85},"2025-02-14","ACTUAL",{"date":87,"type":85},"2023-08-31",{"date":89,"type":76},"2025-12-31",{"name":5,"class":6},1]