[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602875":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":25,"responsibleParty":36,"collaborators":25,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":25,"eligibilityCriteria":44,"healthyVolunteers":45,"sex":46,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":25,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":63,"whyStopped":25,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":25},{"fullName":5,"class":6},"St. Mary's University, Twickenham","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Caffeine","EXPERIMENTAL","5 mg\u002Fkg dose of caffeine (in pill form)",[13,14],"Other: Hot environment","Other: Thermoneutral environment",{"label":16,"type":17,"description":18,"interventionNames":19},"Placebo","PLACEBO_COMPARATOR","5 mg\u002Fkg dose of placebo (maltodextrin - in pill form)",[13,14],[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Hot environment","Hot environment of 35 degrees Celsius",[9,16],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Thermoneutral environment","Thermoneutral environment of 18 degrees Celsius",[9,16],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Mark Glaister","CONTACT","+447957616552","mark.glaister@stmarys.ac.uk",{"type":37,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100602875","the-effects-of-caffeine-on-exercise-physiology-and-time-trial-performance-in-a-hot-environment-100602875",false,"NCT07129200","The Effects of Caffeine on Exercise Physiology and Time-trial Performance in a Hot Environment","The Effects of Caffeine Supplementation on Exercise Physiology and Time-trial Performance in a Hot Environment","Inclusion Criteria:\n\n* Healthy trained runners\n\nExclusion Criteria:\n\n\\-",true,"MALE","18 Years","45 Years",{"count":50,"type":51},15,"ESTIMATED","INTERVENTIONAL",[54],"NA","Maintaining a stable core temperature is vital for physiological function; yet, exercise in heat can be problematic, and there is risk of exertional heat-related illness (Flouris \\& Schlader, 2015; Leyk et al., 2019; Périard et al., 2021; Tyler et al., 2016; Veltmeijer et al., 2015). While aerobic fitness improves heat tolerance (Alhadad et al., 2019), strategies like acclimation and pre-cooling also mitigate heat stress (Casadio et al., 2016; Lorenzo et al., 2010; Ross et al., 2013; Siegel et al., 2010). Caffeine, an ergogenic aid (Del Corso et al., 2011; John et al., 2024), is known to enhance performance via adenosine antagonism and increased catecholamines in normothermic environments (Fredholm et al., 1999; Graham \\& Spriet, 1991). However, effects in heat are inconsistent (Ganio et al., 2009; Zhang et al., 2014), possibly due to caffeine reducing the ability to thermoregulate effectively. Therefore, the aim of this study is to investigate the effects of a moderate dose of caffeine (5 mg\u002Fkg) on thermoregulation during a 30-minute running time trial in 35°C heat.",[9,57],"Thermoregulation",[59,60,61,62],"caffeine","thermoregulation","time trial","exercise physiology","NOT_YET_RECRUITING","2025-08-12",{"date":66,"type":67},"2025-08-19","ACTUAL",{"date":69,"type":51},"2025-08-22",{"date":71,"type":51},"2026-06-30",{"name":5,"class":6}]