[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100054259":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":31,"locations":40,"responsibleParty":60,"collaborators":30,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":30,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":30,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":30,"overallStatus":43,"whyStopped":30,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo","PLACEBO_COMPARATOR","Participants will undergo two test days (Test Day 1 and Test Day 2) separated by 3-7 days. On one test day, participants will consume a single dose of placebo (357 mg\u002Fkg of body weight). Thirty minutes after consuming the placebo, cognitive assessments will be completed including NIH Toolbox cognitive assessments, Senaptec Sensory Station, and driving simulation.",[13],"Dietary Supplement: Placebo",{"label":15,"type":16,"description":17,"interventionNames":18},"ketone monoester (KME)","EXPERIMENTAL","Participants will undergo two test days separated by 3-7 days. On one test day, participants will consume a single dose of ketone monoester (KME) (357 mg\u002Fkg of body weight). Thirty minutes after consuming the KME, cognitive assessments will be completed including NIH Toolbox cognitive assessments, Senaptec Sensory Station, and driving simulation.",[19],"Dietary Supplement: Ketone Monoester (KE)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Ketone Monoester (KE)","Participants will undergo two test days separated by 3-7 days. On both test days, participants will arrive fasted and consume a single dose of ketone monoester or placebo (357 mg\u002Fkg of body weight) in random order. Drinks will be prepared by non-study personnel and matched in taste, texture, and appearance to maintain blinding. Thirty minutes after consuming the ketone monoester or placebo, cognitive assessments will be completed including NIH Toolbox cognitive assessments, Senaptec Sensory Station, and driving simulation.",[15],[15],{"type":22,"name":9,"description":28,"armGroupLabels":29,"otherNames":30},"Participants will undergo two test days separated by 3-7 days. On one test day, participants will consume a single dose of placebo (357 mg\u002Fkg of body weight). Thirty minutes after consuming the placebo, cognitive assessments will be completed including NIH Toolbox cognitive assessments, Senaptec Sensory Station, and driving simulation.",[9],null,[32,37],{"name":33,"role":34,"phone":35,"phoneExt":30,"email":36},"Sarah K Sweatt, PhD","CONTACT","205-975-5398","sksweatt@uab.edu",{"name":38,"role":34,"phone":30,"phoneExt":30,"email":39},"Eric Plaisance","plaisep@uab.edu",[41],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"916 Building","RECRUITING","Birmingham","Alabama","35205","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-86.80249,33.52066,{"lat":53,"lon":52},[56,57],{"name":33,"role":34,"phone":35,"phoneExt":30,"email":36},{"name":58,"role":34,"phone":30,"phoneExt":30,"email":59},"William J Tyler, PhD","wjpt@uab.edu",{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Katherine Sweatt","Principal Investigator","100054259","the-effects-of-exogenous-ketones-on-cognitive-function-100054259",false,"NCT07051655","The Effects of Exogenous Ketones on Cognitive Function","Inclusion Criteria:\n\n* Age 19-55 years\n* BMI 30-40 (obese group) or 18-25 (lean and athlete groups)\n* Sedentary status (\\\u003C2 hrs\u002Fweek of structured physical activity) for obese and lean groups\n* Active athlete status (≥5 days\u002Fweek of structured activity) for athlete group\n\nExclusion Criteria:\n\n* Diagnosed neurological conditions (e.g., Parkinson's disease, multiple sclerosis, schizophrenia, muscular dystrophy, stroke, cerebral palsy)\n* History of seizures\n* Use of medications for diabetes, mood disorders, or attention disorders\n* Pregnant or breastfeeding\n* Current or recent use (within 1 month) of exogenous ketone supplements or adherence to a ketogenic diet",true,"ALL","19 Years","55 Years",{"count":75,"type":76},45,"ESTIMATED","INTERVENTIONAL",[79],"NA","The purpose of this study is to evaluate the acute effects of exogenous ketone monoester (KME) supplementation on cognitive function in three groups of adults aged 19-55 years: (1) obese, sedentary individuals; (2) lean, sedentary individuals; and (3) lean individuals who engage in regular physical activity (e.g., collegiate or amateur athletes). The main questions it aims to answer are to:\n\n* Assess the effects of acute KME supplementation versus placebo on cognitive, sensorimotor, and functional outcomes within groups.\n* Compare cognitive performance across the three groups.\n\nThe primary outcome is cognitive performance assessed using the NIH Toolbox Cognition Battery. Secondary Outcomes include sensorimotor performance, measured using the Senaptec Sensory System, and driving performance, assessed with a driving simulator.",[82,83],"Placebo - Control","Ketone Monoester","2026-07-10",{"date":86,"type":87},"2026-07-13","ACTUAL",{"date":89,"type":87},"2025-12-01",{"date":91,"type":76},"2027-07-31",{"name":5,"class":6},1]