[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100538613":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":25,"responsibleParty":43,"collaborators":45,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":25,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":25,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":74,"whyStopped":25,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":25},{"fullName":5,"class":6},"Hospital Israelita Albert Einstein","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Ischemic conditioning group","EXPERIMENTAL","Therapy will be performed bilaterally on the upper limbs. The ischemic conditioning group will perform 4 times, 8 cycles with 30 seconds of ischemia (80 - 200 mmHg) with 5 seconds of reperfusion in each cycle. Ischemia cycles are controlled by a device (KAATSU C3 - KAATSU GLOBAL \u002F USA) In the first cycle, participants will be subjected to pressures of 80 to 150 mmHg. In the 3 subsequent cycles, pressures from 130 to 200 mmHg will be applied.",[13],"Device: Ischemic conditioning group",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham group","SHAM_COMPARATOR","Participants in the control group (Sham) will perform 4 cycles of 5 minutes of ischemia (30 mmHg) with 4 subsequent cycles of reperfusion (rest) bilaterally in the arms with a sphygmomanometer (Welch Allyn DS44-11BR Durashock).",[19],"Device: Sham group",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","The ischemic conditioning protocol will consist of a period of 12 weeks (24 sessions) with a frequency of 2 weekly sessions lasting between 15 and 20 minutes each. Therapy will be performed bilaterally on the upper limbs. The ischemic conditioning group will perform 4 times, 8 cycles with 30 seconds of ischemia (80 - 200 mmHg) with 5 seconds of reperfusion in each cycle. Ischemia cycles are controlled by a device (KAATSU C3 - KAATSU GLOBAL \u002F USA) with customized ischemia programs, partially restricting blood flow through special pressure cuffs that are internally valved, providing greater comfort and safety for these patients who typically have stiffness in the affected limb and localized muscle pain. In the first cycle, participants will be subjected to pressures of 80 to 150 mmHg. In the 3 subsequent cycles, pressures from 130 to 200 mmHg will be applied.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Participants in the control group (Sham) will perform 4 cycles of 5 minutes of ischemia (30 mmHg) with 4 subsequent cycles of reperfusion (rest) bilaterally in the arms with a sphygmomanometer",[15],[30],{"name":31,"affiliation":5,"role":32},"Kenneth Gollob, PhD","PRINCIPAL_INVESTIGATOR",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},"SAMUEL AMORIM DE SOUZA, Master","CONTACT","11983331912","samuel.amorim.s@gmail.com",{"name":40,"role":36,"phone":41,"phoneExt":25,"email":42},"Kenneth J Gollob, PhD","31 996719224","kjgollob.einstein@gmail.com",{"type":44,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[46],{"name":47,"class":48},"Unifesp Escola Paulista de Medicina","UNKNOWN","100538613","the-effects-of-ischemic-conditioning-in-individuals-with-parkinsons-disease-100538613",false,"NCT06293118","The Effects of Ischemic Conditioning in Individuals with Parkinson's Disease","The Chronic Effect of Ischemic Conditioning on Motor Function, Cognitive Performance, and Immune System in Individuals with Parkinson's Disease","Inclusion Criteria:\n\n* PD patients aged 40 years or older;\n* Diagnosis of PD without cognitive complaints or with complaints, but without impact on daily activities;\n\nExclusion Criteria:\n\n* Patients with uncontrolled diabetes mellitus or peripheral neuropathy;\n* Uncontrolled arterial hypertension (BP\\>160\u002F100mmHg);\n* Uncontrolled diabetes (Fasting glucose \\> 250mg\u002Fdl, peripheral retinopathy or diabetic ketoacidosis);\n* Uncontrolled dyslipidemia (total chol \\> 220mg\u002FdL);\n* Pre-existing autoimmune diseases;\n* Infectious conditions for less than 1 month;\n* Neurological problems that prevent training from being carried out;\n* History of anemia, cerebral vascular disease, myocardial infarction in the last 6 months;\n* Previous deep vein thrombosis;\n* Smoking \\\u003C 6 months;\n* Symptomatic peripheral arterial obstructive disease;\n* Cognitive dysfunction: Moca \\\u003C 24.","ALL","40 Years","90 Years",{"count":60,"type":61},34,"ESTIMATED","INTERVENTIONAL",[64],"NA","Ischemic conditioning (IC) is a promising therapy that can mimic the physiological effects of physical exercise. IC consists of using a cuff to measure blood pressure and calibrate 200 mmHg on the upper or lower limb. Thus, at alternating intervals of 5 minutes, ischemia or reperfusion occurs, depending on whether the cuff is inflated or deflated. IC induces changes in spinal cord excitability for the last reflex reactions of recruited motoneurons with improved balance control in healthy young people and improved learning in the elderly. The objective of the present study is to evaluate the chronic effect of IC on the motor function and cognitive performance of patients with Parkinson's disease. Furthermore, the investigators will evaluate secondary outcomes such as mobility, quality of life, and immunological responses.",[67],"Parkinson Disease",[69,70,71,72,73],"ischemic conditioning","immune system","motor function","cognitive performance","Parkinson disease","NOT_YET_RECRUITING","2024-10-16",{"date":77,"type":78},"2024-10-18","ACTUAL",{"date":80,"type":61},"2025-03-01",{"date":82,"type":61},"2027-09-01",{"name":5,"class":6}]