[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636922":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":23,"collaborators":10,"id":28,"slug":29,"hasResults":30,"nctId":31,"briefTitle":32,"officialTitle":33,"acronym":10,"eligibilityCriteria":34,"healthyVolunteers":35,"sex":36,"minAge":37,"maxAge":10,"enrollmentInfo":38,"targetDuration":10,"studyType":41,"phases":10,"briefSummary":42,"conditions":43,"keywords":10,"overallStatus":46,"whyStopped":10,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":10},{"fullName":5,"class":6},"Istanbul University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Low-Flow Group (LFG)",null,"Anesthesia induction and initial stabilization (first 6-8 minutes at 4-6 L\u002Fmin) follow standard hospital protocols. Fresh Gas Flow (FGF) reduced to 0.5 L\u002Fmin after the target concentration (MACage +1) is reached. Ventilation parameters are adjusted to maintain end-tidal carbon dioxide (EtCO2) between 35-45 mmHg with a minimum FiO2 of 0.30. Volatile anesthetics are discontinued 15 minutes before the estimated end of surgery. Pre-oxygenation and wash-out are performed at 5-6 L\u002Fmin with 80% oxygen prior to extubation.",[13],"Procedure: low flow anesthesia",{"label":15,"type":10,"description":16,"interventionNames":10},"Normal-Flow Group (NFG)","Anesthesia induction and initial stabilization (first 6-8 minutes at 4-6 L\u002Fmin) follow standard hospital protocols. Fresh Gas Flow (FGF) maintained at 2 L\u002Fmin during anesthesia maintenance. Ventilation parameters are adjusted to maintain end-tidal carbon dioxide (EtCO2) between 35-45 mmHg with a minimum FiO2 of 0.30. Volatile anesthetics are discontinued 15 minutes before the estimated end of surgery. Pre-oxygenation and wash-out are performed at 5-6 L\u002Fmin with 80% oxygen prior to extubation.",[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"PROCEDURE","low flow anesthesia","Fresh Gas Flow (FGF) reduced to 0.5 L\u002Fmin after the target concentration (MACage +1) is reached.",[9],{"type":24,"investigatorFullName":25,"investigatorTitle":26,"investigatorAffiliation":27,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Cansu UZUNTURK","specialist in anesthesiology","Haseki Training and Research Hospital","100636922","the-effects-of-low-flow-and-normal-flow-sevoflurane-anesthesia-on-frontal-qrs-t-angle-and-tp-e-interval-100636922",false,"NCT07571980","The Effects of Low-Flow and Normal-Flow Sevoflurane Anesthesia on Frontal QRS-T Angle and TP-e Interval","The Effects of Low-Flow and Normal-Flow Sevoflurane Anesthesia on Frontal QRS-T Angle and TP-e Interval in Patients Undergoing Elective Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* Patients aged 18 years and older.\n* Patients scheduled for elective or semi-elective laparoscopic cholecystectomy.\n* Patients who provide written voluntary informed consent.\n* Patients with a predicted surgical duration between 60 and 180 minutes.\n\nExclusion Criteria:\n\n* Patients with heart failure.\n* Patients with valvular heart disease or pathology.\n* Patients with hemodynamic instability.\n* Patients requiring blood transfusion.\n* Patients with a preoperative corrected QT (QTc) interval \\> 450 ms.\n* Patients with a known history of cardiac arrhythmia.\n* Patients scheduled for emergency surgery.\n* Patients with a known risk or family history of malignant hyperthermia.\n* Use of medications associated with QT interval prolongation (e.g., ketamine, 5-HT3 antagonists, quetiapine, etc.).",true,"ALL","18 Years",{"count":39,"type":40},128,"ESTIMATED","OBSERVATIONAL","Laparoscopic cholecystectomy procedures involve pneumoperitoneum and volatile anesthetics, both of which can significantly influence cardiovascular physiology and autonomic balance. While volatile anesthetics are known to affect myocardial repolarization, the specific impact of Low-Flow Anesthesia (LFA)-a cost-effective and environmentally friendly technique-on these cardiac markers remains under-researched.\n\nThis prospective observational study aims to compare the effects of low-flow versus normal-flow sevoflurane anesthesia on two critical non-invasive biomarkers of ventricular repolarization: the Frontal QRS-T angle and the Tp-e interval. These parameters are essential for predicting electrical instability and the risk of malignant arrhythmias. The study will evaluate a total of 128 patients to determine whether different fresh gas flow rates lead to significant changes in cardiac electrophysiological stability during the perioperative and early postoperative periods.",[44,45],"Cardiac Arrhythmia","Anesthesia","NOT_YET_RECRUITING","2026-04-30",{"date":49,"type":50},"2026-05-07","ACTUAL",{"date":52,"type":40},"2026-05-15",{"date":54,"type":40},"2027-08-15",{"name":5,"class":6}]