[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639586":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":52,"centralContacts":56,"locations":64,"responsibleParty":81,"collaborators":48,"id":84,"slug":85,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":93,"minAge":94,"maxAge":48,"enrollmentInfo":95,"targetDuration":48,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":113,"whyStopped":48,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"Göteborg University","OTHER",[8,14,20,26],{"label":9,"type":10,"description":11,"interventionNames":12},"Test mouth rinse","EXPERIMENTAL","In this arm participants will receive nitrate rich-mouth rinse",[13],"Dietary Supplement: Nitrate-rich mouth rinse",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo mouth rinse","PLACEBO_COMPARATOR","In this arm participants will receive placebo mouth rinse",[19],"Dietary Supplement: Placebo",{"label":21,"type":22,"description":23,"interventionNames":24},"Test drink","ACTIVE_COMPARATOR","In this arm participants will receive nitrate-rich drink",[25],"Dietary Supplement: Nitrate-rich drink",{"label":27,"type":16,"description":28,"interventionNames":29},"Placebo drink","In this arm participants will receive placebo drink",[19],[31,38,44,49],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"DIETARY_SUPPLEMENT","Nitrate-rich mouth rinse","The oral cavity is rinsed with nitrate from mouth rinse, rather than ingested.",[9],[37],"Nitrate mouth rinse",{"type":32,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"Nitrate-rich drink","Nitrate is ingested, rather than rinsed and spit out",[21],[43],"Nitrate drink",{"type":32,"name":45,"description":46,"armGroupLabels":47,"otherNames":48},"Placebo","This mouth rinse is devoid of nitrates",[15],null,{"type":32,"name":45,"description":50,"armGroupLabels":51,"otherNames":48},"This drink is devoid of nitrates",[27],[53],{"name":54,"affiliation":5,"role":55},"Amina Basic, PhD, DDS","PRINCIPAL_INVESTIGATOR",[57,62],{"name":58,"role":59,"phone":60,"phoneExt":48,"email":61},"Simeon KB Mavropoulos, DDS, MSc","CONTACT","+46766185930","simeon.mavropoulos@gu.se",{"name":54,"role":59,"phone":60,"phoneExt":48,"email":63},"amina.basic@gu.se",[65],{"facility":66,"status":48,"city":67,"state":68,"zip":69,"country":70,"countryCode":71,"cosmosGeoPoint":72,"geoPoint":77,"contacts":78},"Odontologen, University of Gothenburg","Gothenburg","Västra Götaland County","41390","Sweden","SE",{"type":73,"coordinates":74},"Point",[75,76],11.96679,57.70716,{"lat":76,"lon":75},[79],{"name":80,"role":59,"phone":60,"phoneExt":48,"email":63},"Amina Basic, DDS, PhD",{"type":55,"investigatorFullName":82,"investigatorTitle":83,"investigatorAffiliation":5,"oldNameTitle":48,"oldOrganization":48},"Amina Basic","PhD, DDS","100639586","the-effects-of-nitrate-rich-mouthwash-on-vascular-tone-100639586",false,"NCT07602764","The Effects of Nitrate-Rich Mouthwash on Vascular Tone","The Short-Term Effects of Nitrate-Rich Mouthwash on Oral Bacterial Nitrite Production, Blood Pressure, and Nitrate and Nitrite Concentrations in Plasma and Saliva of Healthy Adults","NITRATONE","Inclusion Criteria:\n\n* ≥18 years of age; and\n* clinic blood pressure \\\u003C140\u002F\\\u003C90 mmHg.\n\nExclusion criteria:\n\n* hypertension;\n* systemic medication (other than the oral contraceptive pill);\n* antibiotic treatment within the last 3 months;\n* active smoking status and BMI \\> 30;\n* prior gastric by-pass surgery;\n* self-reported use of antiseptic mouthwash or toothpaste;\n* self-reported use of tongue scrapes; and\n* active periodontal disease or caries that needs treatment.",true,"ALL","18 Years",{"count":96,"type":97},20,"ESTIMATED","INTERVENTIONAL",[100],"NA","High blood pressure (hypertension) is a major risk factor for cardiovascular disease. One important contributing factor to high blood pressure is reduced availability of nitric oxide (NO). Therefore, NO is an important molecule in maintaining healthy blood vessel function.\n\nDietary nitrate, found in leafy greens, can serve as an alternative source of nitric oxide in the body. After ingestion, nitrate is converted to nitrite by bacteria residing in the oral cavity. Nitrite can subsequently be converted to NO when swallowed. Therefore, this nitrate-nitrite-nitric oxide pathway is dependent on oral bacteria.\n\nThis study aims to assess whether rinsing the mouth with a nitrate-rich mouth rinse influences blood pressure in healthy adults. Also, concentrations of nitrate and nitrite in plasma and saliva will be measured following the nitrate-mouth rinse exposure.",[103],"Blood Pressure Regulation",[105,106,107,108,109,110,111,112],"Nitrate reduction","Nitrate supplement","Blood pressure regulation","Plasma nitrate","Plasma nitrite","Saliva nitrate","Saliva nitrite","Mouth rinse","NOT_YET_RECRUITING","2026-05-19",{"date":116,"type":117},"2026-05-22","ACTUAL",{"date":119,"type":97},"2026-04",{"date":121,"type":97},"2028-12",{"name":5,"class":6},1]