[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100447891":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":33,"locations":39,"responsibleParty":54,"collaborators":32,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":32,"enrollmentInfo":68,"targetDuration":32,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":32,"overallStatus":41,"whyStopped":32,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Seoul National University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention","EXPERIMENTAL","Exocrine Pacancreatic enzyme(Norzyme Capsule 40000 capsules) after meals 3 times a day",[13],"Drug: Exocrine Pancreatic Enzyme",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","PLACEBO_COMPARATOR","Placebo after meals 3 times a day",[19],"Drug: Placebo",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Exocrine Pancreatic Enzyme","Pancreatic enzyme supplementation for critically ill patients on enteral nutrition",[9],[27],"Norzyme",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Placebo","Placebo of Pancreatic enzyme for critically ill patients on enteral nutrition",[15],null,[34],{"name":35,"role":36,"phone":37,"phoneExt":32,"email":38},"Oh","CONTACT","+82-2-2072-3538","faun1226@gmail.com",[40],{"facility":5,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":32,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Seoul","Jongno-gu","03080","South Korea",{"type":47,"coordinates":48},"Point",[49,50],126.9784,37.566,{"lat":50,"lon":49},[53],{"name":5,"role":36,"phone":32,"phoneExt":32,"email":32},{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","Seung-Young Oh","Clinical Assistant Professor","100447891","the-effects-of-pancreatic-enzyme-supplementation-in-critically-ill-patients-on-enteral-feeding-100447891",false,"NCT05112328","The Effects of Pancreatic Enzyme Supplementation in Critically Ill Patients on Enteral Feeding","The Effects of Pancreatic Enzyme Supplementation in Critically Ill Patients on Enteral Feeding: Prospective Randomized Controlled Trial","PREZENT","Inclusion Criteria:\n\n* Adults 19 years and older\n* Hospitalized in the surgical\u002Fmedical intensive care unit of the Seoul National University Hospital\n* Enteral nutrition\n* Patients who consented to this study\n* Patients with risk factors for pancreatic exocrine dysfunction\n\n  * Shock (Norepinephrine)\n  * Sepsis (3 rd definition of sepsis)\n  * Diabetes\n  * Cardiac arrest\n  * hyperlactatemia serum lactate \\> 2 mmol\u002FL)\n  * Mechanical ventilation\n  * Continuous renal replacement therapy\n\nExclusion Criteria:\n\n* chronic pancreatitis\n* unresectable pancreatic cancer\n* History of pancreatectomy\n* Underlying diseases in which the effect of Exocrine pancreatic enzyme administration is difficult to show\n\n  * Inflammatory bowel disease\n  * Short bowel syndrome","ALL","18 Years",{"count":69,"type":70},170,"ESTIMATED","INTERVENTIONAL",[73],"NA","Determine the effect of high-dose pancreatic enzyme supplementation on nutritional indicators and clinical course in critically ill patients undergoing enteral nutrition.",[76,77,78],"Critically Ill","Enteral Feeding","Exocrine Pancreatic Insufficiency","2021-11-04",{"date":81,"type":82},"2021-11-08","ACTUAL",{"date":84,"type":82},"2021-07-07",{"date":86,"type":70},"2026-07-31",{"name":5,"class":6},1]