[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556809":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":25,"responsibleParty":37,"collaborators":25,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":25,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":48,"minAge":49,"maxAge":25,"enrollmentInfo":50,"targetDuration":25,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":65,"whyStopped":25,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":25},{"fullName":5,"class":6},"Western University, Canada","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Psilocybin First","EXPERIMENTAL","Individuals in this arm will be given psilocybin for their first scanning session. For their second scanning session (at least two weeks later), they will receive the placebo.",[13,14],"Drug: Psilocybin","Other: Placebo",{"label":16,"type":10,"description":17,"interventionNames":18},"Placebo First","Individuals in this arm will be given the placebo for their first scanning session. For their second scanning session (at least two weeks later), they will receive psilocybin.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Psilocybin","Individuals will be given 15 milligrams (mg) of psilocybin orally, and will be asked to lay flat in a functional magnetic resonance imaging (fMRI) brain scanner. The following scans will be collected: anatomical and resting state; while they watch a scrambled film clip; while they watch an intact film clip; while they perform a mental imagery task; while they listen to two pieces of music.\n\nParticipants will then be given two questionnaires: one assessing their overall plot comprehension, and the other asking about their experience in the scanner. They will then be asked to perform a series of visual illusions tasks, and following, play a variety of web-based games assessing their cognitive function. After this, they will be interviewed by one of the study researchers about their overall experience before\u002Fduring\u002Fafter the scan.",[16,9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Placebo","Individuals will be given a placebo orally, and will be asked to lay flat in a functional magnetic resonance imaging (fMRI) scanner. The following scans will be collected: anatomical and resting state; while they watch a scrambled film clip; while they watch an intact film clip; while they perform a mental imagery task; while they listen to two pieces of music.\n\nParticipants will then be given two questionnaires: one assessing their overall plot comprehension, and the other asking about their experience in the scanner. They will then be asked to perform a series of visual illusions tasks, and following, play a variety of web-based games assessing their cognitive function. After this, they will be interviewed by one of the study researchers about their overall experience before\u002Fduring\u002Fafter the scan.",[16,9],[31],{"name":32,"role":33,"phone":34,"phoneExt":35,"email":36},"Adrian M. Owen","CONTACT","519-661-2111","84672","uwocerc@uwo.ca",{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Dr. Adrian Owen","Professor of Cognitive Neuroscience and Imaging","100556809","the-effects-of-psilocybin-on-shared-experience-in-film-processing-100556809",false,"NCT06529939","The Effects of Psilocybin on Shared Experience in Film Processing","Inclusion Criteria:\n\nParticipants must:\n\n* Have access to an internet connection\n* Be in good general health\n* Be 19 years of age, or older\n* Be willing to follow the study protocol\n\nExclusion Criteria:\n\nThe following people will be excluded from the study. Those who:\n\n* Are unable to read English\n* Have high blood pressure\n* Are pregnant (determined by a urine pregnancy test at in-person screening)\n* Are not using effective methods of contraception with their partner(s) (e.g. oral contraceptive pill, injection, implant, patch, vaginal ring, intrauterine coil, intrauterine device, tubal ligation, or barrier method)\n* Are taking chronic administration of tricyclic antidepressants and\u002For lithium\n* Are taking acute administration of serotonin reuptake inhibitors\n* Are currently using the antipsychotic medication haloperidol\n* Are currently using monoamine oxidase inhibitors\n* Have any current or past history of meeting the Diagnostic and Statistical Manual of Mental Illnesses (DSM-V) criteria for schizophrenia, bipolar I, bipolar II, or psychotic symptoms\n* Have any first or second-degree relatives with history of above disorders\u002Fsymptoms\n* Have any other diagnosed and\u002For extreme psychiatric disorders, such as anxiety, depression, post-traumatic stress disorder (PTSD), addiction, obsessive-compulsive disorder (OCD), etc.\n* Have any history of suicidal behaviour or current\u002Frecent suicidal ideation (determined by the Columbia-Suicide Severity Rating Scale \\[C-SSRS\\] at in-person screening)",true,"ALL","19 Years",{"count":51,"type":52},30,"ESTIMATED","INTERVENTIONAL",[55],"NA","The goal of this clinical trial is to learn whether certain methods of detecting awareness in vegetative or minimally conscious patients (using neuroimaging) are sensitive to the effects of psilocybin (a psychedelic drug). One of these methods includes scanning peoples\\' brains while they watch a film. When different individuals watch a film, their brains become synchronized with each other as they watch the plot unfold. Most importantly, if a seemingly unconscious patient also shows the same brain-synchronization, it means they might actually be conscious and aware.\n\nTo approach this goal, the investigators will be carrying out this trial in healthy volunteers. This will help better understand whether psilocybin may be a potential treatment for restoring awareness in these patients. The main questions it aims to answer are:\n\n* Does psilocybin enhance or diminish brain synchrony during a film?\n* Do changes in brain synchrony reflect differences in each individual\\'s conscious experience?\n\nParticipants will be asked to:\n\n* Attend two brain scanning sessions and watch a series of film clips, perform a brief mental imagery task, and listen to music - once under a placebo, and once under psilocybin.\n* Play a series of games that assess their cognition (memory, reasoning, planning, etc.).\n* Perform a series of visual illusions tasks.",[58,59],"Disorders of Consciousness","Psychedelic Experiences",[22,61,62,58,63,64],"Functional Magnetic Resonance Imaging (fMRI)","Cognition","Film Processing","Healthy Volunteers","NOT_YET_RECRUITING","2024-09-24",{"date":68,"type":69},"2024-09-27","ACTUAL",{"date":71,"type":52},"2024-11",{"date":73,"type":52},"2025-09",{"name":5,"class":6}]