[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100509903":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":29,"centralContacts":30,"locations":41,"responsibleParty":60,"collaborators":64,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":29,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":29,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":44,"whyStopped":29,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Istanbul Medipol University Hospital","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Interventional-DLPFC","EXPERIMENTAL","DLPC\u002FF3-F4 group will consist of 20 PD-MCI patients and 20 aMCI patients; 2mA anodal tDCS over DLPFC The current density will be 0.06mA\u002Fcm2 from each electrode with total density of 0.054\u002Fcm2 and will be delivered for 20 minutes for the atDCS group for 5 days a week, for 10 days and a total of 10 sessions in 14 days.",[13],"Procedure: tDCS",{"label":15,"type":10,"description":16,"interventionNames":17},"Interventional-LPC","LPC\u002FP3-P4 group will consist of 20 PD-MCI patients and 20 aMCI patients; 2mA anodal tDCS over LPC The current density will be 0.06mA\u002Fcm2 from each electrode with total density of 0.054\u002Fcm2 and will be delivered for 20 minutes for the atDCS group for 5 days a week, for 10 days and a total of 10 sessions in 14 days.",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Sham","SHAM_COMPARATOR","Sham control group will consist of 40 patients (20 aMCI and 20 PD-MCI patients).\n\n2mA anodal sham tDCS protocol. For the sham protocol, the stimulation will be delivered for one time with a very low current frequency, enough to cause slight tingling, and for 15 seconds long which will also be delivered for 20 minutes, 5 days a week, for 10 days and a total of 10 sessions in 14 days.",[13],[24],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"PROCEDURE","tDCS","0.06mA\u002Fcm2 from each electrode with total density of 0.054\u002Fcm2 for 20 minutes for 5 days a week, for 10 days and a total of 10 sessions in 14 days.\n\nBrain area; DLPFC \u002F LPC",[9,15,19],null,[31,37],{"name":32,"role":33,"phone":34,"phoneExt":35,"email":36},"Burak Yuluğ, Prof. DR. MD","CONTACT","+90 242 510 6135","3505","burakyulug@gmail.com",{"name":38,"role":33,"phone":39,"phoneExt":29,"email":40},"Cennet Sena Parlatan, PhD Cand","+90 507 779 91 64","cennetsenaparlatan@gmail.com",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":29,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Alanya Alaaddin Keykubat Üniversitesi","RECRUITING","Antalya","Alanya","33333","Turkey (Türkiye)",{"type":50,"coordinates":51},"Point",[52,53],30.69556,36.90812,{"lat":53,"lon":52},[56],{"name":57,"role":33,"phone":58,"phoneExt":29,"email":59},"Cennet Sena Parlatan, pHD Cand","05077799164","cennet.parlatan@std.medipol.edu.tr",{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Prof. Lutfu Hanoglu, MD","Prof. Dr. MD",[65],{"name":66,"class":6},"Alanya Alaaddin Keykubat University","100509903","the-effects-of-specific-tdcs-on-cognition-in-mci-100509903",false,"NCT05919485","The Effects of Specific tDCS on Cognition in MCI","The Effects of Specific Transcranial Direct Current Stimulation tDCS on Cognition in Mild Cognitive Impairment: A Novel Study Protocol","Inclusion Criteria:\n\n1. Providing an informed consent;\n2. Literate and between 45-80 years of age;\n3. 60 females and 60 males;\n4. Diagnosed with PD based on criteria suggested by UK Parkinson's Disease Society, Brain Bank and PD-MCI in accordance with the diagnostic criteria suggestions by Litvan;\n5. Diagnosed with aMCI based on diagnosis criteria (CDR\\>0.5) suggested by Petersen;\n6. On a stable pharmacological treatment minimum for one month with no washout period.\n\nExclusion Criteria:\n\n* Illiterate or education level less than primary school\n* Having an existing and\u002For prior neurological disease; psychiatric disease or head trauma; and\u002For irreversible hearing or sight problems or other medical illness (e.g. diabetes mellitus, hypertension);\n* Exhibiting signs of dementia for PD group ;\n* Having medical issues that prevent undergoing fMRI or for tDCS application.","ALL","45 Years","80 Years",{"count":78,"type":79},120,"ESTIMATED","INTERVENTIONAL",[82],"NA","INTRODUCTION:\n\nMild cognitive impairment (MCI) is a critical transitional stage in dementia related disorders. Dorsolateral prefrontal cortex (DLPFC), and the lateral parietal (LPC) cortex are subjected to neuropathological changes in MCI. Parietal memory network (PMN) integrity alterations and default mode network (DMN) alterations also occur in MCI. Transcranial direct current stimulation (tDCS) is a promising neuroprotective tool that modulates functional connectivity and might be useful to interfere with cognitive decline in relation to amnestic MCI (aMCI) and Parkinson's disease-MCI (PD-MCI) when applied to DLPFC and LPC.\n\nMETHODS:\n\nThis is a multicenter, randomized, and controlled study evaluating the effectiveness of anodal tDCS (atDCS ) applied bilaterally to the DLPFC\u002FF3-F4 and LPC\u002F P3-P4 for 5 sessions with a total of 10 sessions in 14 days. The stimulation will be delivered with a 2 mA current frequency and will last 20 minutes a day for 5 days a week. The study consists of anodal, and sham control groups with a total of 120 participants with DLPFC and LPC anodal groups including 40 participants each and sham including 40 participants which are all between 45-80 years of age.\n\nAt baseline and as an outcome measure, neurocognitive evaluation will be conducted using various tests standardized to use in the Turkish population. Functional magnetic resonance (fMRI) will be used to detect possible PMN and DMN alterations and hippocampal connectivity, and electroencephalogram (EEG) will be used to assess possible electrophysiological alterations that may happen as a result of atDCS. Baseline evaluation will be done before atDCS sessions and it will be repeated at the end of 14 days and 90 days.\n\nDISCUSSION:\n\nThis study aims to explore the effectiveness of atDCS in PD-MCI, aMCI and to contribute to the literature in the field.",[85,86],"Alzheimer Disease","Parkinson Disease",[88,89,90,91],"Mild cognitive impairment","Alzheimer's disease","Parkinson's disease","Transcranial direct current stimulation","2025-04-30",{"date":94,"type":95},"2025-05-02","ACTUAL",{"date":97,"type":95},"2023-08-01",{"date":99,"type":79},"2025-12-15",{"name":5,"class":6},1]