[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601332":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":34,"centralContacts":39,"locations":33,"responsibleParty":49,"collaborators":33,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":33,"enrollmentInfo":63,"targetDuration":33,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":76,"overallStatus":82,"whyStopped":33,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":33},{"fullName":5,"class":6},"University of Virginia","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Active Comparator 1: 200mg vitamin C","EXPERIMENTAL","Subjects will supplement with 200mg of vitamin C 2x a day for 3 days. 100mg will be taken in the morning and 100mg in the evening. On the 3rd day, subjects will be scheduled to return for post-supplementation testing and be instructed to take a full 200mg dose 30-minutes prior to arriving.",[13],"Dietary Supplement: Vitamin C (Ascorbic Acid)",{"label":15,"type":10,"description":16,"interventionNames":17},"Active Comparator 1: 500mg vitamin C","Subjects will supplement with 500mg of vitamin C 2x a day for 3 days. Subjects will take half the dose in the morning and half the dose in the evening. On the 3rd day, subjects will be scheduled to return for post-supplementation testing and be instructed to take a full dose 30-minutes prior to arriving.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Active Comparator 1: 1000mg vitamin C","Subjects will supplement with 1000mg of vitamin C 2x a day for 3 days. Subjects will take half the dose in the morning and half the dose in the evening. On the 3rd day, subjects will be scheduled to return for post-supplementation testing and be instructed to take a full dose 30-minutes prior to arriving.",[13],{"label":23,"type":24,"description":25,"interventionNames":26},"Placebo Comparator 1: 0mg Vitamin C","PLACEBO_COMPARATOR","Subjects will supplement with 0mg of vitamin C 2x a day for 3 days. Subjects will take half the dose in the morning and half the dose in the evening. On the 3rd day, subjects will be scheduled to return for post-supplementation testing and be instructed to take a full dose 30-minutes prior to arriving.",[13],[28],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"DIETARY_SUPPLEMENT","Vitamin C (Ascorbic Acid)","Subjects will be supplemented with the following vitamin C doses: 0mg, 200mg, 500mg, 1000mg.",[19,9,15,23],null,[35],{"name":36,"affiliation":37,"role":38},"Jason Allen, PhD","UVA","PRINCIPAL_INVESTIGATOR",[40,45],{"name":41,"role":42,"phone":43,"phoneExt":33,"email":44},"Casey Derella, PhD","CONTACT","434-924-1655","bxg7vn@uvahealth.org",{"name":46,"role":42,"phone":47,"phoneExt":33,"email":48},"Ben Stephenson, M.Ed","434-924-1062","bls4qq@uvahealth.org",{"type":38,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"Jason Allen","Professor","100601332","the-effects-of-vitamin-c-on-acute-exercise-in-postmenopausal-females-100601332",false,"NCT07109115","The Effects of Vitamin C on Acute-Exercise in Postmenopausal Females","The Effects of Vitamin C on Exercise-Induced Oxidative Stress in Postmenopausal Females","PM-VitC","Inclusion Criteria:\n\n* Post-menopausal (for females; defined as no menstrual cycle for 1-year)\n* Sedentary (\\\u003C150min of moderate-intensity exercise per week or not engaged in a regular exercise program)\n* Non-smoking\n* Weight stable (+\u002F-3 kg over the past 3 months)\n\nExclusion Criteria:\n\n* Overt CVD\n* Any condition or medication contraindicating safe exercise\n* Hormone replacement therapy (last 3-months)\n* Use of vasoactive medications (e.g., calcium channel blockers, statins, ACE inhibitors, ARBs, nitrates, alpha-\u002Fbeta-blockers, diuretics), diabetes, or unstable medication regimens\n* Diabetes\n* Oral antibiotic use within previous four weeks\n* Oral disease or poor oral health as determined by the Oral Health Questionnaire\n* Using an antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use\n* Cancer diagnosis",true,"ALL","45 Years",{"count":64,"type":65},30,"ESTIMATED","INTERVENTIONAL",[68],"NA","This study is looking at whether vitamin C can help improve oxidative stress and blood vessel health in females after menopause. We will see if taking different amounts of vitamin C for a few days changes how the body handles stress from exercise. This could lead to safer ways to protect females from heart disease without using hormone therapy.",[71,72,73,74,75],"Females","Males","Menopause","Sedentary","Healthy Participants",[77,78,79,80,81],"Vitamin C","Postmenopausal Females","Exercise","Oxidative Stress","Vascular Health","NOT_YET_RECRUITING","2025-07-30",{"date":85,"type":86},"2025-08-07","ACTUAL",{"date":88,"type":65},"2025-09-01",{"date":90,"type":65},"2027-09-01",{"name":5,"class":6}]