[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638418":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":23,"centralContacts":23,"locations":26,"responsibleParty":44,"collaborators":23,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":23,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":23,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":23,"overallStatus":67,"whyStopped":23,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Chinese University of Hong Kong","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"non-PRP group (control group)","SHAM_COMPARATOR","non-PRP group (control group): non-PRP in the conventional IUI",[13],"Other: non-PRP group (control group)",{"label":15,"type":16,"description":17,"interventionNames":18},"PRP group (intervention group)","EXPERIMENTAL","PRP group (intervention group): female PRP co-incubation with husband's sperm in the IUI",[19],"Other: PRP group (intervention group)",[21,24],{"type":6,"name":9,"description":11,"armGroupLabels":22,"otherNames":23},[9],null,{"type":6,"name":15,"description":17,"armGroupLabels":25,"otherNames":23},[15],[27],{"facility":28,"status":23,"city":29,"state":23,"zip":23,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"The Chinese University of Hong Kong","Hong Kong","China","CN",{"type":33,"coordinates":34},"Point",[35,36],114.17469,22.27832,{"lat":36,"lon":35},[39],{"name":40,"role":41,"phone":42,"phoneExt":23,"email":43},"Chung PW Jacqueline","CONTACT","35051537","jacquelinechung@cuhk.edu.hk",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","Chung Pui Wah Jacqueline","Associate Professor","100638418","the-efficacy-and-safety-of-female-prp-co-incubation-with-sperm-during-iui-cycles-100638418",false,"NCT07615634","The Efficacy and Safety of Female PRP Co-incubation With Sperm During (IUI) Cycles","The Efficacy and Safety of Female Autologous Platelet-Rich Plasma (PRP) Co-incubation With Sperm During the Intrauterine Insemination (IUI) Cycles: A Prospective, Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients who were eligible for IUI cycles in Assissted Reproduction Technolog unit, Prince of Wales Hospital\n* Female patients aged \\>18 years old and \\\u003C 42 years old\n* BMI \\\u003C 30 kg\u002Fm2\n\nExclusion Criteria:\n\n* Concurrent administration of other agents such as prednisolone, intravenous immunoglobulin, or G-CSF\n* Administration of anticoagulants or NSAIDs at least 7 days before PRP infuse\n* Drug addiction\n* Untreated urinary tract infection\n* Underlying uncontrolled diabetes or hypertension, chromosomal or uterine abnormalities, genetic, hematologic, immunological, or endocrine disorders\n* Chronic disease, systemic disease or cancers\n* Blood diseases (sepsis, thrombocytopenia)\n* Poor sperm samples (raw sample TMS \\\u003C5 x 106)\n* Smoking and drinking alcoholic beverages on the day of IUI\n* Fever on the day of IUI\n* Redduse or incomplete in obtaining informed consent","ALL","18 Years","42 Years",{"count":59,"type":60},288,"ESTIMATED","INTERVENTIONAL",[63],"NA","The investigators hypothesize that infertility patients undergoing IUI who receive female autologous platelet-rich plasma (PRP) co-incubation with husband's sperm would have higher clinical pregnancy rate.\n\nPrimary outcome:\n\nTo compare the incidence of clinical pregnancy outcome in those infertility patients undergoing IUI with female PRP co-incubation with husband's sperm group and non-PRP group.\n\nSecondary outcomes:\n\n* To evaluate the post-culture sperm parameters between the intervention group and control group\n* To evaluate the IUI parameter between the intervention group and control group\n* To evaluate the safeness between the female PRP co-incubation with husband's sperm in the IUI group and non-PRP group, including potential infection rate or other pregnancy outcomes such as miscarriage, multiple pregnancy, ectopic pregnancy and molar pregnancy",[66],"Reproductive Issues","NOT_YET_RECRUITING","2026-05-28",{"date":70,"type":71},"2026-05-29","ACTUAL",{"date":73,"type":60},"2026-05-21",{"date":75,"type":60},"2028-05-20",{"name":5,"class":6},1]