[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100557397":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":53,"collaborators":26,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":59,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":26,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Universitas Diponegoro","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Low Level Tragus Stimulation Group","EXPERIMENTAL","Participant will undergo low level tragus stimulation using Parasym Device",[13,14],"Device: Parasym Neuromodulation Device (Treatment Group)","Device: Parasym Neuromodulation Device (Sham Group)",{"label":16,"type":17,"description":18,"interventionNames":19},"Sham Control Group","SHAM_COMPARATOR","Participant will have Parasym Device implanted in their tragus without any active stimulation from the device",[13,14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Parasym Neuromodulation Device (Treatment Group)","Participant will undergo stimulation in their left tragus for 60 minutes by using Parasym device",[9,16],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Parasym Neuromodulation Device (Sham Group)","Participant will undergo implantation of Parasym device lead in their left tragus but without any stimulation for 60 minutes",[9,16],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Leo Deddy Pradipta","CONTACT","+6281316499074","dancingdeagle@gmail.com",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":26,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Dr. Kariadi Central General Hospital","RECRUITING","Semarang","Central of Java","Indonesia","ID",{"type":46,"coordinates":47},"Point",[48,49],110.42083,-6.99306,{"lat":49,"lon":48},[52],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Sodiqur Rifqi","Principal Investigator; Former of Head of Department of Cardiovascular Medicine Faculty of Medicine Universitas Diponegoro","100557397","the-efficacy-and-safety-of-low-level-tragus-stimulation-on-heart-rate-variability-neutrophil-lymphocyte-ratio-and-major-adverse-cardiovascular-events-in-patients-with-st-segment-elevation-myocardial-infarction-tesla-stemi-100557397",false,"NCT06537583","The Efficacy and Safety of Low-Level Tragus Stimulation on Heart Rate Variability, Neutrophil-Lymphocyte Ratio, and Major Adverse Cardiovascular Events in Patients With ST-Segment Elevation Myocardial Infarction (TESLA-STEMI)","The Efficacy and Safety of Low-Level Tragus Stimulation on Heart Rate Variability, Neutrophil-Lymphocyte Ratio, and Major Adverse Cardiovascular Events in Patients With ST-Segment Elevation Myocardial Infarction","TESLA-STEMI","Inclusion Criteria:\n\n* Onset STEMI less than 12 hours\n* Participant agreed to be included in this study\n* Killip class I - II on presentation\n* SBP \\>90 mmHg and\u002For MAP \\>65 mmHg\n* Sinus rhtyhm\n\nExclusion Criteria:\n\n* History of myocardial infarction, stroke, heart failure with reduce ejection fraction, chronic total occlussion on prior coronary angiography, chronic kidney disease (eGFR \\\u003C 30) or on hemodyalisis, malignancy, hematology disease, autoimmune, or other chronic diseases\n* On permanent pacemaker\n* Acute infection\n* Pregnant woman","ALL","18 Years","70 Years",{"count":69,"type":70},100,"ESTIMATED","INTERVENTIONAL",[73],"NA","The goal of this clinical trial is to learn the effect of low level tragus stimulation (LLTS) on heart rate variability (HRV), neutrophil-lymphocyte ratio, and major adverse cardiovascular events in patient with ST-segment Elevation Myocardial Infarction (STEMI). It will also learn about the safety of LLTS in such setting. The main questions, it aims to answer are compared with sham control:\n\n1. Does LLTS could alter low frequency\u002Fhigh frequency ratio in patients with STEMI?\n2. Does LLTS could alter neutrophil-lymphocyte ratio in patients with STEMI?\n3. Does LLTS could decrease mortality in patients with STEMI?\n4. Does LLTS could decrease reinfarction event in patients with STEMI?\n5. Does LLTS could decrease stroke event in patients with STEMI?\n6. Does LLTS could decrease lethal arrhythmia event in patients with STEMI?\n7. Does LLTS could decrease acute lung oedema event in patients with STEMI?\n8. Does LLTS could decrease cardiogenic shock event in patients with STEMI?\n\nResearchers will compare LLTS to sham LLTS control to see if LLTS have benefit in participants with STEMI participants will divided into two group i.e. treatment group vs control (sham\u002Fplacebo) group, then both of them:\n\n1. Undergo laboratory examination before Primary Percutaneous Coronary Intervention (PPCI)\n2. Undergo HRV measurement using WeCardio device before Primary Percutaneous Coronary Intervention (PPCI)\n3. Undergo LLTS (treatment group will have stimulation) for 60 minutes, however, sham control will not have stimulation, before PPCI\n4. Undergo PPCI\n5. Undergo laboratory examination after Primary Percutaneous Coronary Intervention (PPCI)\n6. Undergo HRV measurement using WeCardio device after Primary Percutaneous Coronary Intervention (PPCI)",[76],"ST Elevation Myocardial Infarction",[78,79,80,81,82],"ST segment elevation myocardial infarction","Low level tragus stimulation","Heart rate variability","Neutrophil-lymphocyte ratio","Major adverse cardiovascular events","2024-07-31",{"date":85,"type":86},"2024-08-05","ACTUAL",{"date":88,"type":86},"2024-01-01",{"date":90,"type":70},"2024-09-30",{"name":5,"class":6},1]