[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608454":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":47,"collaborators":25,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":25,"eligibilityCriteria":56,"healthyVolunteers":53,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":25,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":73,"whyStopped":25,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"King Edward Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"The Efficacy of Intralesional Bleomycinin treatment of keloids","EXPERIMENTAL","Group B will be given injection Bleomycin 1.5 IU \u002Fml (15 units vial dilution in 10ml Normal saline) 1 ml of this 1cm apart intralesionally as 0.1- 0.2ml\u002Fcm2 with max dose of 5ml per session and repeat after 2 weeks. Treatment will be given in two groups by a researcher blinded of the treatment being given in each group. POSAS patient and observer scar scale will be used to assess the keloids at 0, 2, 4, 6, 8, 10, and 12 weeks and during follow ups afterwards, assessments will be carried out by another researcher who will assess the improvement on the scale of 0-no improvement, to excellent-75-100% improvement in terms of POSAS variables.",[13],"Drug: intralesional bleomycin",{"label":15,"type":10,"description":16,"interventionNames":17},"The Efficacy of 5-fluorouracil (5-FU) and Triamcinolone Acetonide in treatment of keloids","Group A will be given 1ml if 0.9ml\u002F22.5mg (25mg\u002Fml) of 5-FU with 0.1 ml\u002F4mg (40mg\u002Fml) of Triamcinolone Acetonide, intralesionally 1cm apart, as 0.1- 0.2ml\u002Fcm2 with max dose of 5ml per session and repeat after every 2 weeks.",[18],"Drug: 5-flourouracil and triamcinolone acetonide",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","intralesional bleomycin","The role of intralesional bleomycin for the treatment of keloids needs further establishment in terms of effective concentration, number of sessions and post treatment ulceration or\u002Fand hypopigmentation. Additionally, its comparison to the commonly used and proven, more effective combination than intralesional steroid alone i-e 5-FU in combination with the intralesional steroid, need also be done so that if found affective will be able to deal with the pathological scar as a 1 st line therapeutic drug. With a strong study design and an adequate sample size, and particularly in a specialized tertiary care clinical setup, Our study, seeks to get over the aforementioned limitations, and will delineates the appropriate guidelines for the management of these pathological scars, and suggest option with the best outcomes, as well as lesser side effects and recurrence rates.",[9],null,{"type":21,"name":27,"description":23,"armGroupLabels":28,"otherNames":25},"5-flourouracil and triamcinolone acetonide",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Sayyeda Ifrah Ali, MBBS","CONTACT","+923078696383","dr.shumailadogar@gmail.com",[36],{"facility":5,"status":25,"city":37,"state":25,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":25},"Lahore","54000","Pakistan","PK",{"type":42,"coordinates":43},"Point",[44,45],74.35071,31.558,{"lat":45,"lon":44},{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Shumaila Dogar","Consultant","100608454","the-efficacy-of-intralesional-bleomycin-as-compared-to-5-flourouracil-5-fu-and-triamcinolone-acetonide-tac-for-the-treatment-of-keloids-a-randomized-control-trial-100608454",false,"NCT07201766","The Efficacy of Intralesional Bleomycin as Compared to 5-Flourouracil (5-FU) and Triamcinolone Acetonide (TAC) for the Treatment of Keloids: A Randomized Control Trial.","Inclusion Criteria:\n\n* All, patients aged 13-60 years of age, either gender enrolled for Keloid treatment under local anaesthesia.\n\nExclusion Criteria:\n\n* Allergic to bleomycin, 5-FU DIABETICS VASCULAR INSUFFICIENCY AT THE AFFECTED SITE","ALL","13 Years","60 Years",{"count":61,"type":62},104,"ESTIMATED","INTERVENTIONAL",[65],"NA","The goal of this clinical trial is to learn if drug bleomycin intralesionally is beneficial than intralesional 5FU and Triamcinolone Acetonide in treating Keloids. The main questions it aims to answer are:\n\nDoes drug Bleomycin injected intrasleisonally lower the time duration to effectively treat the keloids in participants as compared to intralesional Triamcinolone Acetonide and 5-Flourouracil? Researchers will compare drug Bleomycin and 5FU plus Triamcinolone Acetonide and determine if bleomycin is better.\n\nParticipants will:\n\nTreatment will be given in two groups by a researcher blinded of the treatment being given in each group. POSAS patient and observer scar scale will be used to assess the keloids at 0, 2, 4, 6, 8, 10, and 12 weeks and during follow ups afterwards, assessments will be carried out by another researcher who will assess the improvement on the scale of 0-no improvement, to excellent-75-100% improvement in terms of POSAS variables. Effectiveness will be indicated by 50% reduction in POSAS score from the baseline.",[68],"Keloids Scars",[70,71,72],"intralesional injection","bleomycin","keloid scars","NOT_YET_RECRUITING","2025-11-23",{"date":76,"type":77},"2025-11-25","ACTUAL",{"date":79,"type":62},"2025-12-02",{"date":81,"type":62},"2026-02-28",{"name":5,"class":6},1]