[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100560909":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":26,"locations":25,"responsibleParty":36,"collaborators":25,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":25,"eligibilityCriteria":45,"healthyVolunteers":42,"sex":46,"minAge":47,"maxAge":25,"enrollmentInfo":48,"targetDuration":25,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":59,"overallStatus":60,"whyStopped":25,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":25},{"fullName":5,"class":6},"Anhui Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Real rTMS group","ACTIVE_COMPARATOR","Participants will receive real transcranial magnetic stimulation (TMS) daily for 1 week.",[13],"Device: transcranial magnetic stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham rTMS group","SHAM_COMPARATOR","Participants will receive sham transcranial magnetic stimulation (TMS) daily for 1 week.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","transcranial magnetic stimulation","The stimulations were performed by MagStim Rapid2.",[9,15],null,[27,32],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},"Panpan Hu, M.D.","CONTACT","13515602285","hpppanda9@126.com",{"name":33,"role":29,"phone":34,"phoneExt":25,"email":35},"Kai Wang, Ph.D.","055162923704","wangkai1964@126.com",{"type":37,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","WANG KAI","Head, Dept of Neurology & Medical Psychology, Director, Cognitive Neuropsychology Lab, PRC","100560909","the-efficacy-of-repetitive-transcranial-magnetic-stimulation-in-parkinson39s-diseasea-randomized-double-blind-multicenter-placebo-controlled-trial-100560909",false,"NCT06583278","The Efficacy of Repetitive Transcranial Magnetic Stimulation in Parkinson's Disease：A Randomized, Double-blind, Multicenter, Placebo-controlled Trial","Inclusion Criteria:\n\n1. Age ≥40 years old\n2. Meet Movement Disorder Society standards;\n3. Have no history of drug adjustment within 4 weeks before and during treatment;\n4. The MDS-UPDRS Ⅲ score ≥8, and the Hoehn-Yahr rating is 1-4\n5. MMSE ≥24，able to cooperate with the completion of behavioral tests and transcranial magnetic stimulation therapy.\n\nExclusion Criteria:\n\n1. Head MRI\u002FCT ruled out focal brain injury or severe leukoencephalopathy (Fazekas grade 3);\n2. Various secondary parkinsonism syndromes (vascular parkinsonism, Parkinsonism combined with parkinsonism, drug parkinsonism, etc.);\n3. Severe craniocerebral trauma, received craniocerebral surgery or deep brain stimulation treatment;\n4. There are ferromagnetic implants in the body, such as cochlear implants, cardiac pacemakers, etc.\n5. The person or first-degree relatives have a history of epilepsy, unexplained loss of consciousness, or are taking anticonvulsant drugs to treat epileptic seizures;\n6. Diagnosed with a neuropsychiatric disorder other than PD\n7. Have a history of drug abuse or drug use;\n8. Participants in any clinical trial within the previous 6 month;\n9. Pregnant\u002Flactating women or subjects (including men) who have a birth plan within 6 months;\n10. Other conditions deemed unsuitable for inclusion by the investigator.","ALL","40 Years",{"count":49,"type":50},312,"ESTIMATED","INTERVENTIONAL",[53],"NA","Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive and widely used neuromodulation technology. Small sample studies have shown that rTMS treatment can significantly improve the symptoms of Parkinson's disease(PD) and delay the progression of the disease. In order to further explore the effectiveness of rTMS in the treatment of PD and lay the foundation for its clinical promotion, our research team plans to conduct a randomized double-blind controlled study of rTMS in the treatment of PD in multiple centers across the country.",[56,57,58],"Parkinson Disease","Transcranial Magenetic Stimualtion","Supplementary Motor Area",[56,57,58],"NOT_YET_RECRUITING","2024-09-01",{"date":63,"type":64},"2024-09-04","ACTUAL",{"date":66,"type":50},"2024-11-01",{"date":68,"type":50},"2027-06-30",{"name":5,"class":6}]