[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100498038":3},{"organization":4,"armGroups":7,"interventions":31,"overallOfficials":49,"centralContacts":53,"locations":63,"responsibleParty":81,"collaborators":36,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":36,"eligibilityCriteria":89,"healthyVolunteers":90,"sex":91,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":36,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":36,"overallStatus":106,"whyStopped":36,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"University of Bern","OTHER",[8,14,19,25],{"label":9,"type":10,"description":11,"interventionNames":12},"SDF solution","PLACEBO_COMPARATOR","Subjects will receive one of the available non-operative treatment methods for root caries, namely silver diamine fluoride solution (SDF \\[38% F-, 38,000 ppm F\\]) twice yearly applied professionally by a dentist, Placebo Tooth mousse twice daily applied at home by the subject and will perform tooth brushing with regular fluoridated toothpaste (NaF, \\[0.32% F-, 1,450 ppm F\\]) twice daily.",[13],"Other: Group A",{"label":15,"type":10,"description":16,"interventionNames":17},"NaF Varnish","Subjects will receive one of the available non-operative treatment methods for root caries, namely sodium fluoride varnish (NaF, \\[5% F-, 22,600 ppm F\\]) twice yearly applied professionally by a dentist, Placebo Tooth mousse twice daily applied at home by the subject and will perform tooth brushing with regular fluoridated toothpaste (NaF, \\[0.32% F-, 1,450 ppm F\\]) toothpaste twice daily.",[18],"Other: Group B",{"label":20,"type":21,"description":22,"interventionNames":23},"Tooth mousse","EXPERIMENTAL","Subjects will receive placebo varnish (water-based) twice yearly applied professionally by a dentist, Biosmalto Tooth mousse twice daily applied at home by the subject and will perform tooth brushing with regular fluoridated toothpaste (NaF, \\[0.32% F-, 1,450 ppm F\\]) toothpaste twice daily.",[24],"Other: Group C",{"label":26,"type":27,"description":28,"interventionNames":29},"Placebo varnish","SHAM_COMPARATOR","Subjects will receive placebo varnish (water-based) twice yearly applied professionally by a dentist, Placebo tooth mousse twice daily applied at home by the subject and will perform tooth brushing with regular fluoridated toothpaste (NaF, \\[0.32% F-, 1,450 ppm F\\]) toothpaste twice daily.",[30],"Other: Group D",[32,37,41,45],{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"Group A","Application of SDF (silver diamine fluoride) solution on the root caries lesions twice yearly in a professional setting. Application of Placebo tooth mousse by the subject twice daily. Regular tooth brushing with standardized fluoridated toothpaste.",[9],null,{"type":6,"name":38,"description":39,"armGroupLabels":40,"otherNames":36},"Group B","Application of Sodium Fluoride varnish on the root caries lesions twice yearly in a professional setting. Application of Placebo tooth mousse by the subject twice daily. Regular tooth brushing with standardized fluoridated toothpaste.",[15],{"type":6,"name":42,"description":43,"armGroupLabels":44,"otherNames":36},"Group C","Application of Placebo varnish (water-based) solution on the root caries lesions twice yearly in a professional setting. Application of Biosmalto tooth mousse by the subject twice daily. Regular tooth brushing with standardized fluoridated toothpaste.",[20],{"type":6,"name":46,"description":47,"armGroupLabels":48,"otherNames":36},"Group D","Application of Placebo varnish (water-based) solution on the root caries lesions twice yearly in a professional setting. Application of Placebo tooth mousse by the subject twice daily. Regular tooth brushing with standardized fluoridated toothpaste.",[26],[50],{"name":51,"affiliation":5,"role":52},"Anastasia Maklennan","PRINCIPAL_INVESTIGATOR",[54,59],{"name":55,"role":56,"phone":57,"phoneExt":36,"email":58},"Guglielmo Campus, Professor","CONTACT","+393473394544","guglielmocampus@gmail.com",{"name":60,"role":56,"phone":61,"phoneExt":36,"email":62},"Marcela Esteves-Oliveira, Professor","+41767248303","marcella.esteves-oliveira@zmk.unibe.ch",[64],{"facility":65,"status":36,"city":66,"state":36,"zip":67,"country":68,"countryCode":69,"cosmosGeoPoint":70,"geoPoint":75,"contacts":76},"Zahnmedizinklinik University of Bern, Department of Restorative, Preventive and Paediatric Dentistry","Bern","3007","Switzerland","CH",{"type":71,"coordinates":72},"Point",[73,74],7.44744,46.94809,{"lat":74,"lon":73},[77,79],{"name":51,"role":56,"phone":61,"phoneExt":36,"email":78},"a.maclennan1@hotmail.com",{"name":80,"role":56,"phone":57,"phoneExt":36,"email":58},"Guglielmo Campus",{"type":82,"investigatorFullName":36,"investigatorTitle":36,"investigatorAffiliation":36,"oldNameTitle":36,"oldOrganization":36},"SPONSOR","100498038","the-efficacy-of-tooth-mouse-sfd-and-naf-in-caries-activity-in-root-caries-a-randomized-clinical-trial-100498038",false,"NCT05765058","The Efficacy of Tooth Mouse, SFD and NaF in Caries Activity in Root Caries. A Randomized Clinical Trial","Randomized Clinical Trial on the Efficacy of Professionally and Self-applied Fluoride Varnishes, Solutions and Mousse on Arresting Root Caries","Inclusion Criteria:\n\n* Being resident in the area of the canton Bern,\n* Age \\>44 years,\n* Three or more root caries\n* Lesions ICDAS (W1 or W2) on the first premolar, canines and front teeth of the upper and lower jaw,\n* Written declaration of informed consent,\n* Capacity to understand questionnaire items related to the compliance of the trial.\n\nExclusion Criteria:\n\n* Living in long-term care facilities, prisons, hospitals etc.,\n* Known allergic reaction to oral hygiene products and\u002For medication and\u002For dental material previously used in the mouth or pharynx,\n* Inability to follow the procedures of filling out questionnaires or clinical examination, e.g. physical inability to fill in questionnaires",true,"ALL","45 Years","95 Years",{"count":95,"type":96},136,"ESTIMATED","INTERVENTIONAL",[99],"NA","The aim of this study is to summarize the current level of evidence on the prevalence of root caries in elderly population, evaluate the prevalence of root caries in elderly patients living in Canton Bern, Switzerland and to analyze the association between the data collected with demographic and relevant socioeconomic factors, provide relevant long-term clinical, radiographic and oral health related outcomes and to establish a pivotal reference in treatment of elderly patients by means of non-operative root caries treatment.",[102,103,104,105],"Root Caries","NaF","SDF","Tooth Mousse","NOT_YET_RECRUITING","2025-09-22",{"date":109,"type":110},"2025-09-24","ACTUAL",{"date":112,"type":96},"2026-02-01",{"date":114,"type":96},"2027-06-28",{"name":5,"class":6},1]