[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609612":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":23,"centralContacts":27,"locations":37,"responsibleParty":56,"collaborators":18,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":18,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":83,"overallStatus":40,"whyStopped":18,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Florida Atlantic University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Pharmacogenomic-Guided Prescribing pathway","EXPERIMENTAL","Pharmacogenomic test results will be transmitted to the participant's primary care physician to support medication optimization and prescribing decisions. Follow-up assessments will be conducted by telephone approximately 14 days after enrollment and then monthly for six months. These structured interviews will capture information on falls, fall-related injuries, medication changes, adverse drug effects, and new medical conditions.\n\nParticipants will also complete a monthly calendar to document medication changes, falls, and fall-related injuries. Medical records from the participant's primary care physician will be reviewed for corroborating information on falls, fall-related injuries, medication changes, medication-related side effects, and newly diagnosed medical problems.",[13],"Other: DNA care pathway",{"label":15,"type":16,"description":17,"interventionNames":18},"Emergency Department care pathway ---control","NO_INTERVENTION","Participants randomized to the current Emergency Department care pathway will continue to receive standard prescribing practices without immediate use of pharmacogenomic results. Follow-up assessments will occur by telephone approximately 14 days after enrollment and then monthly for six months. These calls will collect data on falls, fall-related injuries, medication changes, adverse drug effects, and new medical conditions.\n\nParticipants will also complete a monthly calendar documenting medication changes, falls, and fall-related injuries. Medical records from the participant's primary care physician will be reviewed to identify additional falls, injuries, medication changes, side effects, and new medical problems. At the conclusion of the study, pharmacogenomic testing results will be provided to the participant's primary care physician to support future prescribing decisions.",null,[20],{"type":6,"name":21,"description":11,"armGroupLabels":22,"otherNames":18},"DNA care pathway",[9],[24],{"name":25,"affiliation":5,"role":26},"Richard Shih, MD","PRINCIPAL_INVESTIGATOR",[28,34],{"name":29,"role":30,"phone":31,"phoneExt":32,"email":33},"Richard Shih, Professor, MD","CONTACT","561-737-7733","87410","rshih@health.fau.edu",{"name":35,"role":30,"phone":31,"phoneExt":32,"email":36},"Scott Alter, Professor, MD","alters@health.fau.edu",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Delray Medical Center","RECRUITING","Delray Beach","Florida","33484","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-80.07282,26.46146,{"lat":50,"lon":49},[53],{"name":54,"role":30,"phone":18,"phoneExt":18,"email":55},"Gabriella Engstrom","gengstr1@health.fau.edu",{"type":26,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Richard Shih","Principal Investigator, MD","100609612","the-geriatric-emergency-department-pharmacologic-harm-prevention-project-100609612",false,"NCT07216846","The Geriatric Emergency Department Pharmacologic Harm Prevention Project","GREAT PHARM","Inclusion Criteria:\n\n* Patients over the age of 65 with a ground level fall\n\nExclusion Criteria:\n\n* hospice and\u002For DNR status.","ALL","65 Years","110 Years",{"count":70,"type":71},1000,"ESTIMATED","INTERVENTIONAL",[74],"NA","The goal of this project is to determine whether pharmacogenomic testing (using participants' DNA) can help optimize medication prescribing and reduce side effects in older adults taking five or more medications.\n\nThe main questions it aims to answer are:\n\n* Can DNA-based prescribing reduce medication-related side effects, especially falls and fall-related injuries?\n* Does providing pharmacogenomic results to primary care physicians improve medication safety compared with usual care?\n\nResearchers will compare two groups:\n\n1. DNA Care Pathway: Physicians receive patients' DNA results to guide prescribing.\n2. Emergency Department Care Pathway: Physicians provide usual care; DNA results are shared only after study completion.\n\nParticipants will:\n\n* Provide a cheek swab sample for DNA analysis (1 minute).\n* Receive monthly follow-up phone calls for 6 months to track falls, injuries, medication changes, and side effects.\n* Complete a fall and medication calendar.\n* Allow researchers to review primary care physician medical records for study outcomes.\n\nApproximately 1,000 participants will take part, with follow-up lasting about 6-7 months.",[77,78,79,80,81,82],"Fall","Fall Accident","Poly Pharmacy","Adverse Drug Events","Pharmacogenomic Drug Interaction","Pharmacogenomic Testing",[77,84,85,86],"Geriatric","Pharmacogenomic","adverse drug event","2026-01-07",{"date":89,"type":90},"2026-01-08","ACTUAL",{"date":92,"type":90},"2026-01-01",{"date":94,"type":71},"2027-12-31",{"name":5,"class":6},1]