[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624905":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":37,"centralContacts":41,"locations":46,"responsibleParty":63,"collaborators":66,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":27,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":27,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":27,"overallStatus":48,"whyStopped":27,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of Miami","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Motivational Interviewing + Probiotic","EXPERIMENTAL","Participants in this arm will be given a brief motivational interview to promote drinking reduction. During the 30-day intervention, participants will receive an active probiotic supplement 900 billion colony forming units (CFU), once daily.",[13,14],"Dietary Supplement: Visbiome","Behavioral: Motivational Interviewing",{"label":16,"type":17,"description":18,"interventionNames":19},"Motivational Interviewing + Placebo","PLACEBO_COMPARATOR","Participants in this arm will be given a brief motivational interview to promote drinking reduction. During the 30-day intervention, participants will receive a placebo supplement once daily.",[14,20],"Other: Placebo",[22,28,33],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DIETARY_SUPPLEMENT","Visbiome","Participants will receive 900 billion Colony Forming Units (CFU) once daily for 30 days",[9],null,{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":27},"BEHAVIORAL","Motivational Interviewing","Participants will receive one counseling session at baseline via video call, lasting up to 30 minutes",[16,9],{"type":6,"name":34,"description":35,"armGroupLabels":36,"otherNames":27},"Placebo","Participants will receive a standard placebo designed to resemble the probiotic once daily for 30 days",[16],[38],{"name":39,"affiliation":5,"role":40},"Teddy Salan, PhD","PRINCIPAL_INVESTIGATOR",[42],{"name":39,"role":43,"phone":44,"phoneExt":27,"email":45},"CONTACT","305-243-9228","txs785@med.miami.edu",[47],{"facility":5,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","Miami","Florida","33136","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-80.19366,25.77427,{"lat":58,"lon":57},[61,62],{"name":39,"role":43,"phone":44,"phoneExt":27,"email":45},{"name":39,"role":40,"phone":27,"phoneExt":27,"email":27},{"type":40,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"Teddy Salan","Research Assistant Professor",[67],{"name":68,"class":69},"Exegi Pharma","UNKNOWN","100624905","the-glucid-study-effect-of-alcohol-reduction-and-probiotic-interventions-on-cognition-and-brain-glucose-metabolism-in-normal-aging-adults-who-are-high-risk-alcohol-drinkers-100624905",false,"NCT07415707","The GLUCID Study: Effect of Alcohol Reduction and Probiotic Interventions on Cognition and Brain Glucose Metabolism in Normal Aging Adults Who Are High-Risk Alcohol Drinkers","Effect of Alcohol Reduction and Probiotic Interventions on Cognition and Brain Glucose Metabolism in Normal Aging Adults Who Are High-Risk Alcohol Drinkers","Inclusion Criteria:\n\n* Between 65 and 84 years of age\n* English speaking\n* Able to provide valid informed consent, understand requirement and risk\u002Fbenefits of the study and comply with study protocol\n* Heavy drinker defined as \\>14 alcoholic drinks\u002Fweek for men and \\>7 drinks\u002Fweek for women\n* Interested in reducing their alcohol consumption\n\nExclusion Criteria:\n\n* BMI ≥ 35\n* Fasting Glucose \\> 125 mg\u002FdL\n* Current or previously diagnosed with Type 1 or 2 Diabetes\n* Requires the use of insulin and\u002For other glucose lowering agents\n* Unable to fast for 12 hours\n* Past serious alcohol withdrawal symptoms\n* MRI Contraindications (e.g., certain devices and implants, claustrophobic)\n* Diagnosed with a neurodegenerative disease (e.g., Alzheimer's Disease)\n* Diagnosed with a psychotic disorder\n* Current substance dependence diagnosis (except for mild or moderate alcohol)\n* Consumption of over 300 drinks in the past 30 days\n* Current probiotic use or recent probiotic use within the past 30 days\n* Current antibiotic use or recent antibiotic use within the past 30 days\n* In active cancer treatment and\u002For have advanced cancer\n* Taking daily steroids and\u002For immunosuppressants\n* Lifetime organ or bone marrow transplant; primary immunodeficiency (e.g., DiGeorge syndrome or Wiskott-Aldrich syndrome) or transplant recipient or prescribed immunosuppressant medications\n* PI's discretion","ALL","65 Years","84 Years",{"count":81,"type":82},20,"ESTIMATED","INTERVENTIONAL",[85],"NA","The goal of this pilot study is to explore a combination of two interventions: (1) a behavioral alcohol-reduction intervention using motivational interviewing, and (2) a blinded probiotic microbiome or placebo intervention. The study examines whether these interventions improve cognitive and neurophysiological function, including brain metabolism, in older adults who are high-risk alcohol drinkers.",[88,89],"Aging","Alcohol Drinking","2026-03-03",{"date":92,"type":93},"2026-03-04","ACTUAL",{"date":95,"type":93},"2026-02-26",{"date":97,"type":82},"2027-04-30",{"name":5,"class":6},1]