[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100574708":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":31,"responsibleParty":52,"collaborators":20,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":20,"eligibilityCriteria":61,"healthyVolunteers":58,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":20,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":76,"overallStatus":34,"whyStopped":20,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Baylor College of Medicine","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Perinatal HIE","EXPERIMENTAL","Newborns diagnosed with moderate or severe perinatal hypoxic-ischemic encephalopathy (HIE) who are undergoing therapeutic hypothermia will receive genome sequencing to identify co-morbid genetic conditions. Participants' genetic data will be analyzed for copy number variations (CNVs), single nucleotide variants (SNVs), and triplet repeat disorders per ACMG reporting standards.",[13],"Genetic: Genome sequencing",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"GENETIC","Genome sequencing","Neonates enrolled in this study will undergo genome sequencing with parental controls as applicable.",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Christian Parobek, MD, PhD","CONTACT","828-713-9962","christian.parobek@bcm.edu",{"name":28,"role":24,"phone":29,"phoneExt":20,"email":30},"Seema Lalani, MD","7137988921","seemal@bcm.edu",[32,48],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Texas Children's Hospital","RECRUITING","Houston","Texas","77030","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-95.36327,29.76328,{"lat":44,"lon":43},[47],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":49,"geoPoint":51,"contacts":20},{"type":41,"coordinates":50},[43,44],{"lat":44,"lon":43},{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Seema Lalani","Professor","100574708","the-hienome-study-genome-sequencing-for-perinatal-hie-100574708",false,"NCT06762795","The HIEnome Study: Genome Sequencing for Perinatal HIE","Inclusion Criteria:\n\n* Delivery ≥35w0d gestation\n* Diagnosed with moderate or severe HIE, or HIE with seizures\n* Undergoing total body cooling \u002F therapeutic hypothermia\n* Able to provide blood or buccal samples during birth hospitalization\n* Admitted to Texas Children's Hospital Main, West, or Woodlands NICU\n\nExclusion Criteria:\n\n* Parents\u002Ffamily not willing to allow participation\n* Inability to collect sufficient neonatal blood samples (in some circumstances, a buccal swab may be used as backup)","ALL","0 Days","1 Year",{"count":66,"type":67},25,"ESTIMATED","INTERVENTIONAL",[70],"NA","Perinatal hypoxic-ischemic encephalopathy is a rare severe condition in which neonates present with encephalopathy and a clinical history suggestive of prenatal or perinatal hypoxic-ischemic injury. Emerging evidence suggests that genetic conditions are frequently identified in cases of perinatal HIE; however, it is unclear which neonates with this diagnosis warrant genetic testing. This study will offer clinical genome sequencing to neonates with HIE who are undergoing total body cooling (therapeutic hypothermia) and their parents.",[73,74,75],"Hypoxic Ischemic Encephalopathy of Newborn","Hypoxic Ischemic Encephalopathy","Hypoxic Ischemic Encephalopathy (HIE)",[77,78,17],"Hypoxic-ischemic encephalopathy","Genetic testing","2025-09-25",{"date":81,"type":82},"2025-10-01","ACTUAL",{"date":84,"type":82},"2025-05-15",{"date":86,"type":67},"2027-06-30",{"name":5,"class":6},2]