[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100572742":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":23,"centralContacts":27,"locations":33,"responsibleParty":52,"collaborators":23,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":23,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":79,"overallStatus":36,"whyStopped":23,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"University of British Columbia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Fasting + Exercise (FAST+EX): fasting + exercise condition","EXPERIMENTAL","48-hour fast with 60 minutes of cycling on the first and second day of the fast.",[13],"Other: Fasting + Exercise (FAST+EX): fasting + exercise condition",{"label":15,"type":10,"description":16,"interventionNames":17},"Fasting only (FAST): Non-exercise fasting condition","48-hour fast with no structured exercise on fasting days.",[18],"Other: Fasting only (FAST): Non-exercise fasting condition",[20,24],{"type":6,"name":9,"description":21,"armGroupLabels":22,"otherNames":23},"Participants will complete a 48-hour fast. One hour of exercise will be performed on each morning of the fast.",[9],null,{"type":6,"name":15,"description":25,"armGroupLabels":26,"otherNames":23},"Participant will complete a 48-hour fast. No structured exercise will be performed during each of the fasting days.",[15],[28],{"name":29,"role":30,"phone":31,"phoneExt":23,"email":32},"Jonathan Little Principal Investigator, Professor Little, Ph.D","CONTACT","250-807-9876","jonathan.little@ubc.ca",[34],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"University of British Columbia Okanagan Campus","RECRUITING","Kelowna","British Columbia","V1V1V7","Canada","CA",{"type":43,"coordinates":44},"Point",[45,46],-119.48568,49.88307,{"lat":46,"lon":45},[49],{"name":50,"role":30,"phone":31,"phoneExt":23,"email":51},"Alexis Marcotte-Chénard Postdoctoral fellow, Ph.D","alexis.marcottechenard@ubc.ca",{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","Jonathan Little","Professor","100572742","the-impact-of-a-48-hour-fast-with-or-without-exercise-on-immune-cell-metabolism-and-glycemic-control-in-healthy-active-adults-100572742",false,"NCT06737224","The Impact of a 48-hour Fast with or Without Exercise on Immune Cell Metabolism and Glycemic Control in Healthy Active Adults","The Impact of a 48-hour Fast with or Without Exercise on Immune Cell Function, Bioenergetics, and Glycemic Control in Healthy Active Adults: a Randomized Crossover Trial","FASTEX","Inclusion Criteria:\n\n* Aged between 19 and 35 years.\n* Physically active (engaging in ≥150 minutes of weekly moderate to vigorous physical activity).\n\nExclusion Criteria:\n\n* History of cardiometabolic diseases or inflammatory diseases (e.g., chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, cardiovascular disease).\n* Individuals currently following a ketogenic diet, low-calorie diet, periodic fasting regimen, or consuming ketogenic supplements (e.g., exogenous ketone drinks).\n* Cigarette\u002Fvaping smoking.\n* Physical limitation that will impair the ability of the participant to perform exercise.\n* Individuals having a body mass index (BMI) over 30 kg\u002Fm2.\n* Cancer diagnosis in the past 5 years.\n* Taking anti-inflammatory drugs (e.g., ibuprofen, aspirin, naproxen).\n* Being unable to read or communicate in English.",true,"ALL","19 Years","35 Years",{"count":69,"type":70},15,"ESTIMATED","INTERVENTIONAL",[73],"NA","Many individuals engage in fasting for its purported health benefits but the effects of fasting on immune cell and whole body metabolism are not well understood in humans. Moreover, how exercising during a prolonged fast impacts immunometabolic outcomes is unclear. This study will determine how a 2 day fast - performed with or without daily exercise - impacts immune cell bioenergetics, immune cell function, and whole-body glycemic control in healthy active individuals.",[76,77,78],"Fasting","Immune Function","Glucose Tolerance",[80,81,82],"Exercise","Immunometabolism","Glycemic control","2025-03-04",{"date":85,"type":86},"2025-03-07","ACTUAL",{"date":88,"type":86},"2025-01-10",{"date":90,"type":70},"2025-08-01",{"name":5,"class":6},1]