[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629610":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":18,"responsibleParty":31,"collaborators":18,"id":35,"slug":36,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":40,"acronym":18,"eligibilityCriteria":41,"healthyVolunteers":42,"sex":43,"minAge":44,"maxAge":18,"enrollmentInfo":45,"targetDuration":18,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":55,"overallStatus":60,"whyStopped":18,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":18},{"fullName":5,"class":6},"Instituto Politécnico de Castelo Branco","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Aerobic Exercise Group","EXPERIMENTAL","Group of participants who will take part in a supervised aerobic exercise program.",[13],"Behavioral: Aerobic exercise program",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group","NO_INTERVENTION","A group of participants who will maintain their usual routines, without any systematic practice of physical exercise.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","Aerobic exercise program","Supervised moderate-intensity aerobic exercise program based on ACSM and WHO recommendations. Sessions will be delivered 3 times per week for 60 minutes, fully supervised by a certified exercise professional. Each session includes: (1) 5-10 min warm-up (joint mobility and light walking), (2) 30-50 min continuous aerobic exercise (primarily walking) targeting large muscle groups at 50-70% HRmax (Borg RPE 5-7), and (3) 5-10 min active recovery and static stretching. Intensity and progression will follow ACSM guidance, starting at light-to-moderate intensity and increasing continuous aerobic duration by \\~5 min\u002Fweek during the first 4 weeks, with subsequent individualized adjustments according to participants' adaptations. Adherence will be tracked via attendance logs, with ≥80% session attendance required for adequate compliance. Safety will be ensured through continuous monitoring for adverse events (e.g., chest pain, palpitations, abnormal dyspnea) with immediate session interruption an",[9],[26],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},"Carlos M Farinha, Carlos Farinha, Dr.","CONTACT","+351924167929","cmnfarinha@gmail.com",{"type":32,"investigatorFullName":33,"investigatorTitle":34,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Carlos Farinha","Principal Researcher","100629610","the-impact-of-aerobic-exercise-program-on-immunosenescence-institutionalized-older-adults-100629610",false,"NCT07476911","The Impact of Aerobic Exercise Program on Immunosenescence Institutionalized Older Adults","The Impact of Aerobic Exercise Program on Immunosenescence in Institutionalized Older Adults: a Study Protocol for Randomized Controlled Trials","Inclusion criteria:\n\nParticipants must be aged 60 years or older and institutionalized. Studying institutionalised older adults ensures greater uniformity in diet, daily routines, behaviours, and environmental exposures, thereby minimising the impact of external factors other than the exercise intervention.\n\nExclusion criteria:\n\nParticipants will be excluded if they have acute conditions that may affect their immune or inflammatory responses. These conditions include recent trauma or surgery (within the previous six months), recent blood transfusions (within the previous month), acute infections (such as respiratory, gastrointestinal, or urinary infections), recent vaccinations, and the use of medications that may interfere with immune responses (such as immunomodulators, systemic corticosteroids, methotrexate, and biologics).",true,"ALL","60 Years",{"count":46,"type":47},40,"ESTIMATED","INTERVENTIONAL",[50],"NA","Background: Immunosenescence is an age-related decline in immune function, associated with chronic low-grade inflammation, increased morbidity, and functional impairment in older adults. Aerobic exercise has been proposed as an effective non-pharmacological strategy to counteract these alterations; however, evidence from randomized-controlled trials (RCTs), particularly in institutionalized elderly populations, remains scarce and methodologically limited.\n\nObjective: This study protocol aims to investigate the effects of short- and medium-term aerobic exercise programs on immunosenescence in institutionalized older adults, as well as to analyze the impact of a detraining period and a subsequent reintervention.\n\nMethods: A stratified RCT will be conducted with institutionalized adults aged ≥60 years, randomly allocated to an aerobic exercise group or a control group. The intervention consists of a supervised 12-week moderate-intensity aerobic exercise program (three sessions\u002Fweek), followed by a 4-week detraining period and a 4-week reintervention. Assessments will be performed at five time points. Primary outcomes include immunological and analytical parameters assessed by spectral flow cytometry and multiplex cytokine analysis. Secondary outcomes include anthropometry, functional capacity, hemodynamic parameters, heart rate variability, and psychological indicators.\n\nExpected Results: Aerobic exercise is expected to induce favorable immunological adaptations, partially reverse immunosenescence, and improve functional and psychosocial outcomes.",[53,54],"Immunosenescence","Aging",[56,57,54,58,59,53],"Aerobic exercise","Elderly","Institutionalized","Immune system","NOT_YET_RECRUITING","2026-03-12",{"date":63,"type":64},"2026-03-17","ACTUAL",{"date":66,"type":47},"2026-03-02",{"date":68,"type":47},"2026-10-30",{"name":5,"class":6}]