[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629690":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":12,"centralContacts":25,"locations":32,"responsibleParty":48,"collaborators":12,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":12,"enrollmentInfo":62,"targetDuration":12,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":75,"whyStopped":12,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Qianfoshan Hospital","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"conventional ventilation group","NO_INTERVENTION","Total Intravenous Anesthesia (TIVA) + Volume-Controlled Ventilation (VCV) The procedure was performed with total intravenous anesthesia (TIVA) combined with volume-controlled ventilation (VCV). The settings for the lung-protective ventilation strategy were as follows: tidal volume was maintained at 6-8 mL\u002Fkg predicted body weight (PBW) (calculated as: 50 + 0.91 × \\[height (cm) - 152.4\\] for males; 45.5 + 0.91 × \\[height (cm) - 152.4\\] for females). The inspiratory-to-expiratory ratio was set at 1:2, and a positive end-expiratory pressure (PEEP) of 5 cmH₂O was applied intraoperatively. The ventilation rate was adjusted according to intraoperative end-tidal carbon dioxide (PetCO₂) to maintain PetCO₂ within the range of 35-50 mmHg.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Automated recruitment maneuver (Auto-RM) group","EXPERIMENTAL","Automated recruitment maneuvers (Auto-RM) were performed using the HuaSheng Lavender anesthesia machine at 10 min after intubation\u002Flaryngeal mask insertion and again 10 min before the end of surgery, in addition to TIVA with VCV. Using the PEEP incremental method in PCV mode (respiratory rate 10\u002Fmin, I:E 1:1, driving pressure 10-15 cmH₂O), PEEP was increased by 5 cmH₂O every 30 s from baseline until peak pressure reached 40 cmH₂O. PEEP was then gradually decreased, and the level corresponding to the minimum driving pressure (DP = Pplat - PEEP) was recorded and maintained. Other ventilator settings were identical to the control group.",[18],"Device: Automated recruitment maneuver (Auto-RM)",[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":12},"DEVICE","Automated recruitment maneuver (Auto-RM)","In addition to total intravenous anesthesia (TIVA) combined with volume-controlled ventilation (VCV), an automated recruitment maneuver was performed using the HuaSheng Lavender intravenous anesthesia machine at 10 minutes after intubation or laryngeal mask insertion and again at 10 minutes before the end of surgery. The maneuver employed the PEEP incremental method as follows: the ventilator was set to pressure-controlled ventilation (PCV) mode with a respiratory rate of 10 breaths\u002Fmin, an inspiratory-to-expiratory ratio of 1:1, and a controlled pressure maintained at 10-15 cmH₂O. Starting from the baseline PEEP level, PEEP was increased by 5 cmH₂O every 30 seconds until peak pressure reached 40 cmH₂O. Subsequently, PEEP was gradually decreased, and the PEEP level corresponding to the minimum driving pressure (DP = plateau pressure - PEEP) during the recruitment process was recorded and maintained intraoperatively.",[14],[26],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},"Liu Mengjie, Doctoral Degree","CONTACT","0531-89268535","+8615628920681","liumengjie31@163.com",[33],{"facility":34,"status":12,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"The First Affiliated Hospital of Shandong First Medical University (Shandong Qianfoshan Hospital)","Jinan","Shandong","250014","China","CN",{"type":41,"coordinates":42},"Point",[43,44],116.99722,36.66833,{"lat":44,"lon":43},[47],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"SPONSOR_INVESTIGATOR","Yongtao Sun","professor","100629690","the-impact-of-automatic-lung-recruitment-postoperative-pulmonary-complications-100629690",false,"NCT07477951","The Impact of Automatic Lung Recruitment Postoperative Pulmonary Complications","The Effect of Automatic Lung Re-expansion on Postoperative Pulmonary Function in Elderly Patients Undergoing Laparoscopic Surgery Under Total Intravenous Anesthesia: A Prospective, Single-center, Randomized Controlled Trial","lung","Inclusion Criteria:\n\n* aged≥65 years\n* American Society of Anesthesiologists (ASA) grades I-III;\n* Body mass index (BMI) between 18-30kg\u002Fm²\n* No history of drug allergy or abnormal anesthesia;\n* Patients undergoing laparoscopic gastrointestinal surgery, and operative time\\> 2 hours;\n* Participants with a preoperative oxygen saturation not \\\u003C 94%\n* Participants for whom extubation is planned in the operating room.\n* The assess respiratory risk in surgical patients in Catalonia (ARISCAT) score is 26-44 or \\> 44.\n\nExclusion Criteria:\n\n* ALI or ARDS patient within 3 months; severe pulmonary dysfunction; severe COPD (FEV1 \\\u003C50% of predicted value) or pulmonary hypertension;\n* New York Heart Association classification: Class IV;\n* Chronic renal failure(GFR\\\u003C30ml min-11.73m-2);\n* Severe liver disease;\n* Patients with confusion and cognitive dysfunction;\n* Severe coagulation disorders;\n* Patients with tracheal tubes transported to the ICU;\n* Other reasons;","ALL","65 Years",{"count":63,"type":64},58,"ESTIMATED","INTERVENTIONAL",[67],"NA","Study Background and Purpose As society ages, an increasing number of elderly patients undergo surgery. Following surgery, particularly abdominal procedures, patients are susceptible to lung-related issues such as atelectasis (lung collapse) and infection, collectively known as Postoperative Pulmonary Complications (PPCs). These complications are a major factor affecting the recovery of elderly patients.\n\nOne method of general anesthesia is called Total Intravenous Anesthesia (TIVA). This study aims to investigate whether using an automated lung recruitment function, a smart feature available on modern anesthesia machines, can help protect lung function and reduce complications in elderly patients undergoing laparoscopic surgery under TIVA. The goal is to identify safer and more effective methods for anesthesia care.\n\nStudy Design\n\nThis is a clinical research study. Eligible elderly patients who provide consent will be randomly assigned to one of two groups:\n\nStudy Group: The automated lung recruitment function on the anesthesia machine will be used to manage breathing during surgery.\n\nControl Group: Current standard methods for breathing management will be used during surgery.\n\nThe primary goal is to observe and compare the blood oxygenation level 30 minutes after surgery (a key indicator of lung function) between the two groups. The investigators will also record the occurrence of any lung-related complications within the first 3 days after surgery.\n\nWhat Will Participants Do?\n\nIf participants agree to participate, they will be asked to:\n\nSign an informed consent form.\n\nUndergo some pre-operative assessments arranged by the research team.\n\nReceive the corresponding breathing management method during surgery, as determined by random assignment.\n\nAllow the research team to collect relevant medical data after surgery (e.g., blood gas analysis results, medical records). All data will be kept strictly confidential.\n\nParticipation does not involve any additional invasive procedures. All medical care and monitoring will adhere to the standard safety protocols required for the surgery, and may even be more meticulous.\n\nPotential Benefits and Risks of the Study\n\nPotential Benefits:\n\nDirect Benefit: Participants will receive more precise monitoring and care for their respiratory function during and after surgery.\n\nSocietal Value: Data from their participation will contribute to developing better anesthesia strategies for future elderly patients, potentially improving their recovery outcomes.\n\nPotential Risks and Protections:\n\nThe study intervention is integrated into standard anesthesia. The main risks are associated with routine anesthesia and surgery itself (e.g., temporary blood pressure fluctuations, low oxygen levels). These risks are possible in any similar surgical procedure.\n\nThe study will be conducted by experienced anesthesiologists with continuous, close monitoring. Comprehensive emergency plans are in place to ensure participant safety.\n\nParticipants have the right to withdraw from the study at any time, for any reason, without affecting their eligibility for any future standard medical care.\n\nAll personal information and study data will be kept strictly confidential. Data will be analyzed using coded identifiers only. Any published results will not contain information that could reveal the identity of participants.",[70],"Acute Lung Injury",[22,72,73,74],"Total Intravenous Anesthesia (TIVA)","postoperative pulmonary complications (PPCs)","acute lung injury (ALI)","NOT_YET_RECRUITING","2026-03-13",{"date":78,"type":79},"2026-03-17","ACTUAL",{"date":81,"type":64},"2026-04-01",{"date":83,"type":64},"2027-06-30",{"name":50,"class":6},1]