[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100485858":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":26,"centralContacts":33,"locations":39,"responsibleParty":53,"collaborators":26,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":26,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":26,"enrollmentInfo":65,"targetDuration":26,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":26,"overallStatus":41,"whyStopped":26,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"University Hospital Hradec Kralove","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"10 % hemodilution","EXPERIMENTAL","Recumbent surgery:\n\n* infusion rate in first 20 minutes: 15 ml\u002Fkg\u002Fh\n* infusion rate after 20 minutes: 2,6 ml\u002Fkg\u002Fh\n\nLaparoscopic surgery:\n\n* infusion rate in first 20 minutes: 16 ml\u002Fkg\u002Fh\n* infusion rate after 20 minutes: 0,8 ml\u002Fkg\u002Fh",[13],"Drug: Crystalloid Solutions",{"label":15,"type":10,"description":16,"interventionNames":17},"20 % hemodilution","Recumbent surgery:\n\n* infusion rate in first 20 minutes: 26 ml\u002Fkg\u002Fh\n* infusion rate after 20 minutes: 3,4 ml\u002Fkg\u002Fh\n\nLaparoscopic surgery:\n\n* infusion rate in first 20 minutes: 28 ml\u002Fkg\u002Fh\n* infusion rate after 20 minutes: 1,6 ml\u002Fkg\u002Fh",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"30 % hemodilution","Recumbent surgery:\n\n* infusion rate in first 20 minutes: 38 ml\u002Fkg\u002Fh\n* infusion rate after 20 minutes: 5,1 ml\u002Fkg\u002Fh\n\nLaparoscopic surgery:\n\n* infusion rate in first 20 minutes: 44 ml\u002Fkg\u002Fh\n* infusion rate after 20 minutes: 2,4 ml\u002Fkg\u002Fh",[13],{"label":23,"type":24,"description":25,"interventionNames":26},"Standart care","NO_INTERVENTION","Infusion rate based upon the standard care.",null,[28],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":26},"DRUG","Crystalloid Solutions","Locally approved crystalloid solution will be given at the predefined infusion rate",[9,15,19],[34],{"name":35,"role":36,"phone":37,"phoneExt":26,"email":38},"David Astapenko, MD, PhD","CONTACT","+420495833218","david.astapenko@fnhk.cz",[40],{"facility":5,"status":41,"city":42,"state":26,"zip":43,"country":44,"countryCode":26,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Hradec Králové","50005","Czechia",{"type":46,"coordinates":47},"Point",[48,49],15.83277,50.20923,{"lat":49,"lon":48},[52],{"name":35,"role":36,"phone":37,"phoneExt":26,"email":38},{"type":54,"investigatorFullName":35,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Deputy Head for Science and Research","100485858","the-impact-of-intra-operative-fluid-infusion-rate-on-microcirculation-100485858",false,"NCT05606536","The Impact of Intra-operative Fluid Infusion Rate on Microcirculation","The Impact of Intra-operative Fluid Infusion Rate on Hemodilution and Microcirculation Prospective Observational Pilot Study","Inclusion Criteria:\n\n* elective recumbent and laparoscopic surgery\n* informed consent\n\nExclusion Criteria:\n\n* blood loss over 250 ml\n* hemodynamic instability requiring noradrenaline infusion","ALL","18 Years",{"count":66,"type":67},80,"ESTIMATED","INTERVENTIONAL",[70],"NA","Intraoperative fluid therapy (IFT) is an integral part of anesthesia care during surgery. Its main indication is the optimization of oxygen supply to the tissues. For elective surgery that is not associated with higher blood loss and a long period of preoperative fasting, including fluids IFT is dosed to cover the basal daily need for fluids. However, it is not clear whether this fluid dose is optimal. Surgery is a stress factor that leads, among other things, to damage of the endothelial glycocalyx (EG). EG binds a significant amount of plasma, which is released during EG destruction and causes relative hemodilution.\n\nIsovolumic hemodilution is an established intraoperative procedure that serves to better control bleeding in procedures where bleeding is expected. However, partial hemodilution occurs even with standard IFT, and even when fluids are hardly given at all. Flow parameters in microcirculation have not yet been described depending on IFT conduction. The parameters of the microcirculation reflect its functioning, which will consequently affect the postoperative phase of the patient's moaning and clinical outcome.",[73,74,75],"Fluid Therapy","Microcirculation","Hemodilution","2025-03-24",{"date":78,"type":79},"2025-03-27","ACTUAL",{"date":81,"type":79},"2022-10-01",{"date":83,"type":67},"2025-12-31",{"name":5,"class":6},1]