[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634556":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":30,"responsibleParty":47,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":10,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":10,"enrollmentInfo":58,"targetDuration":10,"studyType":61,"phases":10,"briefSummary":62,"conditions":63,"keywords":69,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Konya City Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Study Cohort",null,"Adult patients aged 18 to 85 years with ASA physical status III-IV, who are scheduled to undergo elective cardiac surgery under general anesthesia.",[13],"Other: Chronic Antihypertensive Medication Use",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Chronic Antihypertensive Medication Use","Patients' chronic antihypertensive drug use (number of drugs and pharmacological classes) will be recorded. This is an observational study where existing medication regimens (ACE inhibitors, ARBs, Beta-blockers, Calcium Channel Blockers, Diuretics) are documented to analyze their impact on the post-induction hypotension burden (MAP \\\u003C 55 mmHg).",[9],[20],"Multiple Antihypertensive Therapy",[22],{"name":23,"affiliation":5,"role":24},"Mustafa Aydemir, MD","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":10,"email":29},"CONTACT","+905378725583","drmustafaaydemir02@gmail.com",[31],{"facility":32,"status":33,"city":34,"state":10,"zip":35,"country":36,"countryCode":10,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"University of Health Sciences, Konya City Hospital","RECRUITING","Konya","42080","Turkey (Türkiye)",{"type":38,"coordinates":39},"Point",[40,41],32.48464,37.87135,{"lat":41,"lon":40},[44],{"name":45,"role":27,"phone":46,"phoneExt":10,"email":29},"Mustafa Aydemir","05378725583",{"type":24,"investigatorFullName":45,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Principal Investigator","100634556","the-impact-of-multiple-antihypertensive-therapy-on-post-induction-hypotension-burden-in-cardiac-surgery-patients-100634556",false,"NCT07541222","The Impact of Multiple Antihypertensive Therapy on Post-Induction Hypotension Burden in Cardiac Surgery Patients","The Impact of Multiple Antihypertensive Therapy on Post-Induction Hypotension Burden in Cardiac Surgery Patients: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Adult patients aged 40 years and older\n* Undergoing elective cardiac surgery (e.g., isolated CABG, isolated valve surgery, or combined CABG+valve surgery via sternotomy)\n* Regular use of at least one antihypertensive medication for at least 4 weeks prior to the operation date\n* Voluntary participation and signed informed consent\n\nExclusion Criteria:\n\n* Emergency surgery\n* Preoperative shock or requirement for high-dose inotropic\u002Fvasopressor therapy\n* End-stage liver or kidney failure\n* Uncontrolled hypertension\n* Difficult intubation or prolonged induction process\n* Ejection fraction less than 35%","ALL","40 Years",{"count":59,"type":60},160,"ESTIMATED","OBSERVATIONAL","This study aims to investigate the impact of multiple preoperative antihyperstensive drug use on the burden of post-induction hypotension (PIH) in patients undergoing elective cardiac surgery. The researchers will observe whether the combination of different antihypertensive classes (such as ACE inhibitors, ARBs, beta-blockers, and calcium channel blockers) leads to a higher incidence and severity of blood pressure drops and increased need for vasoactive support during the period between anesthesia induction and surgical incision.",[64,65,66,67,68],"Hypotension on Induction","Cardiac Surgery","Antihypertensive Agents","Anesthesia, Intravenous","Hemodynamics",[70,71,72,73,74,75],"Post-induction hypotension","Cardiac surgery","Antihypertensive drugs","Hypotension burden","Mean arterial pressure","Anesthesia induction","2026-05-05",{"date":78,"type":79},"2026-05-06","ACTUAL",{"date":81,"type":79},"2026-05-01",{"date":83,"type":60},"2026-12-01",{"name":5,"class":6},1]