[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100419090":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":42,"responsibleParty":59,"collaborators":25,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":66,"acronym":25,"eligibilityCriteria":67,"healthyVolunteers":64,"sex":68,"minAge":69,"maxAge":25,"enrollmentInfo":70,"targetDuration":25,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":81,"overallStatus":44,"whyStopped":25,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Nighttime cycled enteral feeds first","EXPERIMENTAL","Patients will start nighttime cycled enteral feeds first for 12 hours. Following a 24-hour washout period, patients will then start daytime cycled enteral feeds for 12 hours.",[13],"Dietary Supplement: Time-of-day of enteral nutrition provision (nighttime first)",{"label":15,"type":10,"description":16,"interventionNames":17},"Daytime cycled enteral feeds first","Patients will start daytime cycled enteral feeds first for 12 hours. Following a 24-hour washout period, patients will then start nighttime cycled enteral feeds for 12 hours.",[18],"Dietary Supplement: Time-of-day of enteral nutrition provision (daytime first)",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Time-of-day of enteral nutrition provision (daytime first)","Enteral nutrition (tube feeds) will be provided during the daytime followed by nighttime.",[15],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Time-of-day of enteral nutrition provision (nighttime first)","Enteral nutrition (tube feeds) will be provided during the nighttime followed by daytime.",[9],[31],{"name":32,"affiliation":5,"role":33},"Hassan S Dashti, Ph.D., R.D.","PRINCIPAL_INVESTIGATOR",[35,39],{"name":32,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","617-643-7167","chrononutrition@mgh.harvard.edu",{"name":40,"role":36,"phone":25,"phoneExt":25,"email":41},"Richa Saxena, Ph.D.","rsaxena@partners.org",[43],{"facility":5,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Boston","Massachusetts","02114","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-71.05977,42.35843,{"lat":54,"lon":53},[57],{"name":58,"role":36,"phone":25,"phoneExt":25,"email":25},"Hassan S Dashti",{"type":33,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Hassan Dashti","Principal Investigator","100419090","the-impact-of-overnight-nutrition-support-on-sleep-and-circadian-rhythm-disruption-in-the-icu-100419090",false,"NCT04737200","The Impact of Overnight Nutrition Support on Sleep and Circadian Rhythm Disruption in the ICU","Inclusion Criteria:\n\n* Adult male or non-pregnant female volunteers (age 18+)\n* Scheduled for a cardiac surgical procedure with planned post-operative admission to the ICU for \\>48 hours\n* Able and willing to give consent and comply with study procedures\n\nExclusion Criteria:\n\n* Blind, deaf or unable to speak English\n* Women who are pregnant or nursing\n* Contraindications to safe use enteral nutrition, including gastrointestinal obstruction\n* Personal history of intestinal malabsorption, gallbladder disease or pancreatitis\n* Dietary restrictions precluding enteral feeds\n* Renal and liver failure requiring dialysis or Child-Pugh score \\> 7\n* Severe deficit due to structural or anoxic brain damage\n* With skin condition that precludes wearing sensors","ALL","18 Years",{"count":71,"type":72},30,"ESTIMATED","INTERVENTIONAL",[75],"NA","The purpose of this study is to determine whether modifying the timing of nutrition support from overnight to daytime enhances sleep quality, preserves circadian rhythms, and improves overall inflammation and cardiometabolic profiles in postoperative patients in the cardiac surgical ICU on enteral nutrition.",[78,79,80],"Feeding Patterns","Sleep","Glucose Intolerance",[82,83,84,85,86,79],"Enteral Nutrition","Chrononutrition","Intensive Care Unit","Chronobiology","Nutrition Support","2026-05-18",{"date":89,"type":90},"2026-05-19","ACTUAL",{"date":92,"type":90},"2022-02-08",{"date":94,"type":72},"2027-03-31",{"name":5,"class":6},1]