[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100573796":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":27,"locations":33,"responsibleParty":51,"collaborators":10,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":10,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":10,"enrollmentInfo":62,"targetDuration":65,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":72,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Kocaeli City Hospital","OTHER_GOV",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Cardiovascular collapse",null,"\"- At least one documented episode of SpO₂ \\\u003C 80%, ensuring accuracy of measurement.\n\n* At least one episode of systolic arterial blood pressure (SAB) \\\u003C 65 mmHg.\n* SAB \\\u003C 90 mmHg sustained for a duration of 30 minutes.\n* Initiation of norepinephrine therapy.\n* Escalation of pre-existing norepinephrine infusion dose.\n* Administration of \\>15 mL\u002Fkg crystalloid fluids to achieve SAB \\> 90 mmHg.\n* Occurrence of cardiac arrest.\" The occurrence of any of the above-mentioned events within the first 30 minutes following the initiation of the intervention will be considered as cardiovascular collapse.",[13,14],"Other: propofol","Other: ketamine",{"label":16,"type":10,"description":10,"interventionNames":17},"No Cardiovascular collapse",[13,14],[19,24],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"OTHER","propofol","The hemodynamic effects of propofol and ketamine are well-documented in the general patient population, yet the incidence and characteristics of cardiovascular collapse induced by these agents in critically ill patients remain underexplored. Cardiovascular collapse, a severe and potentially life-threatening event, may arise due to the unique physiological stressors present in the critical care setting, including pre-existing hemodynamic instability, comorbidities, and the administration of high-risk pharmacological agents. Despite the theoretical understanding of these drugs' pharmacodynamics, there is limited evidence assessing their differential impact on cardiovascular function in this vulnerable population.\n\nThis study aims to contribute novel insights to the literature by exploring the association between these widely used sedative-hypnotic agents and the development of cardiovascular collapse. While propofol is known for its potent vasodilatory and myocardial depressive effects,",[9,16],{"type":20,"name":25,"description":22,"armGroupLabels":26,"otherNames":10},"ketamine",[9,16],[28],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},"Ömer Emgin, MD","CONTACT","+90 262 225 27 00","omermgin@yahoo.com",[34],{"facility":5,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":10,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"RECRUITING","Köseköy","Kocaeli","41060","Turkey (Türkiye)",{"type":41,"coordinates":42},"Point",[43,44],30.00556,40.74012,{"lat":44,"lon":43},[47],{"name":48,"role":30,"phone":49,"phoneExt":10,"email":50},"+90 262 225 27 00 3853 Kocaeli City Hospital","+90-262-225-27-00","omeremgin@yahoo.com",{"type":52,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100573796","the-impact-of-propofol-and-ketamine-on-cardiovascular-collapse-during-induction-for-intubation-100573796",false,"NCT06750939","The Impact of Propofol and Ketamine on Cardiovascular Collapse During Induction for Intubation","The Impact of Propofol and Ketamine on Cardiovascular Collapse During Induction for Endotracheal Intubation in Critically Ill Patients: A Prospective Observational Study","Inclusion Criteria:\n\n* Patients aged over 18 years\n* Patients admitted to the intensive care unit (ICU) who undergo endotracheal intubation during their ICU stay will be included.\n\nExclusion Criteria:\n\n* Patients who did not provide consent to participate in the study\n* Patients intubated due to cardiac arrest\n* Patients intubated outside the intensive care unit","ALL","18 Years",{"count":63,"type":64},128,"ESTIMATED","30 Days","OBSERVATIONAL","This prospective observational study evaluates the impact of propofol and ketamine on the risk of cardiovascular collapse during induction for endotracheal intubation in critically ill patients. Induction agents play a crucial role in managing hemodynamic stability, particularly in this vulnerable population. Propofol, known for its vasodilatory and myocardial depressant effects, has been associated with significant hypotension during induction. Conversely, ketamine, with its sympathomimetic properties, is often considered a safer alternative for hemodynamic stability.\n\nIn addition to comparing the incidence of cardiovascular collapse-defined as severe hypotension or cardiac arrest-this study examines the relationship between these induction agents and shock indices, including systolic shock index, diastolic shock index, age-adjusted shock index, and modified shock index. These parameters will provide a more detailed understanding of the hemodynamic effects of each agent and their clinical implications. The findings aim to guide induction agent selection to optimize outcomes in critically ill patients.",[69,70,71],"Cardiovascular Collapse","Intubation Complication","Anaesthetic Complication Cardiac",[73,74,75],"cardiac arrest","intubation","shock index","2025-09-16",{"date":78,"type":79},"2025-09-22","ACTUAL",{"date":81,"type":79},"2024-07-15",{"date":83,"type":64},"2025-11-01",{"name":5,"class":6},1]