[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100475233":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":26,"locations":32,"responsibleParty":49,"collaborators":25,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":25,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":25,"maxAge":25,"enrollmentInfo":61,"targetDuration":25,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":25,"overallStatus":34,"whyStopped":25,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Old Dominion University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Metabolic","EXPERIMENTAL","Metabolic: Participants will have their blood glucose levels measured via continuous glucose monitoring for 3 days while participating in their normal exercise routines (EX). Participants will also have their blood glucose levels measured for 3 days while not exercising (NOEX), following immediately by 3 days of a return to normal activity(REX). Participants will be randomized to participate in the EX or NOEX\u002FREX phases first. The EX and NOEX\u002FREX phases will be separated by at least 1 week",[13],"Other: removal of exercise",{"label":15,"type":10,"description":16,"interventionNames":17},"Vascular","Vascular: Participants will have their blood vessel health measured while performing their normal exercise routines (EX) and while undergoing 1, 3, 5 days of no exercise (NOEX) followed immediately by 1 and 3 days of return to exercise (REX).",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"removal of exercise","Subjects will stop doing their normal exercise routines for 3 or 5 days and then subjects will resume doing their normal exercise routines for 3 days.",[9,15],[24],"return to exercise",null,[27],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},"Leryn Reynolds","CONTACT","757-683-4974","lreynold@odu.edu",[33],{"facility":5,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"RECRUITING","Norfolk","Virginia","23529","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-76.28522,36.84681,{"lat":44,"lon":43},[47],{"name":48,"role":29,"phone":30,"phoneExt":25,"email":31},"Leryn J Reynolds",{"type":50,"investigatorFullName":28,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Assistant Professor","100475233","the-impact-of-removal-of-exercise-on-glycemic-control-and-vascular-health-in-older-active-adults-100475233",false,"NCT05468255","The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active Adults","The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active","Inclusion Criteria:\n\n1. 55 years and older, 18-40 years old\n2. Healthy, physically active, performing at least 90 min\u002Fweek of physical activity\n3. Free of physical limitations that may interfere with alterations in daily physical activity levels\n\nExclusion Criteria:\n\n1. Physician diagnosed HIV, hepatitis, or tuberculosis.\n2. Body weight change of greater than 5% within the previous 2 months\n3. Smoking within the previous 2 months.\n4. Taking medications that alter blood glucose levels",true,"ALL",{"count":62,"type":63},40,"ESTIMATED","INTERVENTIONAL",[66],"NA","The purpose of this study is to determine if an acute bout of removal of exercise reduces enothelial function and glycemic control in an active, older adult population; and whether a 3 day return to exercise restores this response. Glycemic control is the blood glucose response following the consumption of a meal. It is an indicator of insulin resistance (or type 2 diabetes) and impaired glycemic control has been suggested to lead to cardiovascular disease. Endothelial function has been shown to be improved by chronic or acute increases in physical activity. Both of these have been shown to be impaired to acute bouts of inactivity in young populations; however the impact of acute inactivity in older adults is less understood. In this proposal the investigators will examine 1)how quickly impairments in glycemic control occur to acute physical inactivity in older adults who exercise, 2) how quickly impairments in endothelial function occur to acute inactivity in older adults who exercise, and 3) whether 3 days of a return to exercise restores these responses.",[69,70,71],"Glucose Intolerance","Exercise","Vascular Function","2024-04-09",{"date":74,"type":75},"2024-04-10","ACTUAL",{"date":77,"type":75},"2022-07-25",{"date":79,"type":63},"2025-04-01",{"name":5,"class":6},1]