[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100545635":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":10,"responsibleParty":29,"collaborators":10,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":37,"acronym":10,"eligibilityCriteria":38,"healthyVolunteers":39,"sex":40,"minAge":41,"maxAge":42,"enrollmentInfo":43,"targetDuration":10,"studyType":46,"phases":10,"briefSummary":47,"conditions":48,"keywords":53,"overallStatus":60,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":10},{"fullName":5,"class":6},"University Hospital Sestre Milosrdnice","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients undergoing open rhinoplasty approach",null,"Patients undergoing open rhinoplasty approach, of which most of will be augmented by using autologous cartilage grafts.",{"label":13,"type":10,"description":14,"interventionNames":10},"Patients undergoing closed approach rhinoplasty.","Patients undergoing closed approach rhinoplasty of which only few will be augmented by using autologous cartilage grafts.",[16],{"name":17,"affiliation":18,"role":19},"Marko Velimir Grgić, MD, PhD","UHC Sestre milosrdnice","STUDY_CHAIR",[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Mateo Čukman, MD","CONTACT","+385992642621","mateo.cukman@hotmail.com",{"name":17,"role":23,"phone":27,"phoneExt":10,"email":28},"+385993787059","marko_grgic@yahoo.com",{"type":30,"investigatorFullName":31,"investigatorTitle":32,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Mateo Čukman","medical doctor, resident","100545635","the-impact-of-rhinoplasty-approach-and-used-autologous-cartilage-grafts-on-the-nasal-skin-soft-tissue-envelope-metabolism-100545635",false,"NCT06384469","The Impact of Rhinoplasty Approach and Used Autologous Cartilage Grafts on the Nasal Skin-soft Tissue Envelope Metabolism","Inclusion Criteria:\n\n* Adult patients undergoing primary functional rhinoplasty who comply with the study\n* Adult patients undergoing primary functional rhinoplasty who have singed the informed consent, previously approved by the ethics commitee.\n\nExclusion Criteria: -\n\n* patients with previous surgical procedures to the nose\n* patients with greater previous injury or burns to the nasal skin\n* patients with autoimmune skin conditions\n* patients with significant cardiovascular diseases\n* patients unwilling to comply with the study\n* patients who do not want to sign the informed consent, previously approved by the ethics commitee.",true,"ALL","18 Years","80 Years",{"count":44,"type":45},100,"ESTIMATED","OBSERVATIONAL","This is a prospective observation cohort investigation. Patients, that is participants, undergoing primary functional rhinoplasty will be evaluated in terms of measuring capillary blood lactic acid concentration in the nasal skin-soft tissue envelope immediately after the procedure and 7 days after the procedure.\n\nThe aim of our study is to test whether or not different rhinoplasty approaches and volume of the used autologous cartilage grafts impact the nasal skin-soft tissue metabolism.",[49,50,51,52],"Rhinoplasty","Nasal Skin-soft Tissue Envelope Metabolism","Lactic Acid","Autologous Cartilage Grafting",[54,55,56,57,58,59],"Open rhinoplasty approach","Closed rhinoplasty approach","Lactic acid","Skin-soft tissue envelope","Metabolism","Autologous cartilage grafting","NOT_YET_RECRUITING","2024-04-25",{"date":63,"type":64},"2024-04-29","ACTUAL",{"date":66,"type":45},"2025-01-02",{"date":68,"type":45},"2026-09-01",{"name":5,"class":6}]